INT738

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1977
Last Reported 2010
Negated 85
Speculated 61
Reported most in Abstract
Documents 459
Total Number 520
Disease Relevance 111.19
Pain Relevance 243.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
plasma 101
blood 16
pituitary 15
CSF 11
brain 9
POMC (Homo sapiens)
POMC - A2M (1) POMC - A2L (1)
Pain Link Frequency Relevance Heat
Enkephalin 1022 100.00 Very High Very High Very High
narcan 432 100.00 Very High Very High Very High
Opioid 390 100.00 Very High Very High Very High
Pain 275 100.00 Very High Very High Very High
opiate 216 100.00 Very High Very High Very High
antagonist 168 100.00 Very High Very High Very High
agonist 154 100.00 Very High Very High Very High
Morphine 153 100.00 Very High Very High Very High
Serotonin 137 100.00 Very High Very High Very High
Acupuncture 132 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 600 100.00 Very High Very High Very High
Pain 260 100.00 Very High Very High Very High
Cancer 96 100.00 Very High Very High Very High
Hypoglycemia 52 100.00 Very High Very High Very High
Hemorrhage 40 100.00 Very High Very High Very High
Hypoxia 17 100.00 Very High Very High Very High
Nicotine Addiction 13 100.00 Very High Very High Very High
Hypercapnia 12 100.00 Very High Very High Very High
Necrosis 12 100.00 Very High Very High Very High
Cystitis 9 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Metyrapone effects on beta-endorphin, ACTH and cortisol levels after chronic opiate receptor stimulation in man.
Regulation (effects) of beta-endorphin associated with opiate
1) Confidence 0.62 Published 1990 Journal Neuropeptides Section Title Doc Link 2174517 Disease Relevance 0 Pain Relevance 0.30
Metyrapone effects on beta-endorphin, ACTH and cortisol levels after chronic opiate receptor stimulation in man.
Regulation (effects) of ACTH associated with opiate
2) Confidence 0.62 Published 1990 Journal Neuropeptides Section Title Doc Link 2174517 Disease Relevance 0 Pain Relevance 0.30
The mean plasma ACTH and cortisol levels and the mean maximal changes in these levels were significantly lower during the clonidine + fenfluramine test than during fenfluramine alone.
Regulation (changes) of ACTH in plasma associated with clonidine
3) Confidence 0.62 Published 1988 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 2856056 Disease Relevance 0.18 Pain Relevance 1.19
The results suggest an opponent process in catecholaminergic regulation of beta-endorphin in humans, and are consistent with observations in the central nervous system of animal models.
Regulation (regulation) of beta-endorphin in central nervous system associated with central nervous system
4) Confidence 0.62 Published 1996 Journal Psychiatry Res Section Abstract Doc Link 8804130 Disease Relevance 0.41 Pain Relevance 0.15
Effect of intrathecal morphine during labor on maternal plasma beta-endorphin levels.
Regulation (Effect) of beta-endorphin in plasma associated with morphine and intrathecal
5) Confidence 0.62 Published 1984 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 6087663 Disease Relevance 0 Pain Relevance 0.54
Several investigators have speculated that variations in beta-endorphin secretory regulation may precede the development of a substance use disorder, and thus be a component of the liability for substance abuse.
Regulation (regulation) of beta-endorphin associated with drug dependence and drug abuse
6) Confidence 0.62 Published 1996 Journal Psychiatry Res Section Abstract Doc Link 8804130 Disease Relevance 0.42 Pain Relevance 0.27
The administration of naloxone itself had no significant effect on ACTH or cortisol levels.
Neg (no) Regulation (effect) of ACTH associated with narcan
7) Confidence 0.62 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8090278 Disease Relevance 0.06 Pain Relevance 0.43
Effect of ACTH, epinephrine, beta-endorphin, naloxone, and of the combination of naloxone or beta-endorphin with ACTH or epinephrine on memory consolidation.
Regulation (Effect) of beta-endorphin associated with narcan
8) Confidence 0.62 Published 1983 Journal Psychoneuroendocrinology Section Title Doc Link 6308701 Disease Relevance 0.13 Pain Relevance 0.29
Effect of ACTH, epinephrine, beta-endorphin, naloxone, and of the combination of naloxone or beta-endorphin with ACTH or epinephrine on memory consolidation.
Regulation (Effect) of ACTH associated with narcan
9) Confidence 0.62 Published 1983 Journal Psychoneuroendocrinology Section Title Doc Link 6308701 Disease Relevance 0.12 Pain Relevance 0.29
Basal ACTH and cortisol levels were also not significantly altered by SV (P > 0.30).
Neg (not) Regulation (altered) of ACTH
10) Confidence 0.62 Published 1995 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 8582096 Disease Relevance 0 Pain Relevance 0.53
Experiments on anaesthetized male Sprague-Dawley rats were performed to study the effects of adrenocorticotropic hormone (ACTH) on pain sensitivity.
Regulation (effects) of ACTH associated with pain
11) Confidence 0.61 Published 2003 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 14635995 Disease Relevance 0.26 Pain Relevance 0.65
Experiments on anaesthetized male Sprague-Dawley rats were performed to study the effects of adrenocorticotropic hormone (ACTH) on pain sensitivity.
Regulation (effects) of adrenocorticotropic hormone associated with pain
12) Confidence 0.61 Published 2003 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 14635995 Disease Relevance 0.26 Pain Relevance 0.65
In order to establish possible alterations in the secretory patterns of adrenocorticotropic hormone (ACTH), cortisol and/or beta-endorphin in bulimia nervosa, the circadian fluctuations of these hormones were evaluated in blood samples taken at 1-hour intervals over 24 h.
Spec (possible) Regulation (alterations) of ACTH in blood associated with eating disorder
13) Confidence 0.61 Published 1996 Journal Neuropsychobiology Section Abstract Doc Link 8927231 Disease Relevance 0.48 Pain Relevance 0
Experiments on conscious male Sprague-Dawley rats were performed to study the effects of adrenocorticotropic hormone (ACTH) on pain reactions.
Regulation (effects) of ACTH associated with pain
14) Confidence 0.61 Published 2004 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 15368903 Disease Relevance 0.27 Pain Relevance 0.53
Experiments on conscious male Sprague-Dawley rats were performed to study the effects of adrenocorticotropic hormone (ACTH) on pain reactions.
Regulation (effects) of adrenocorticotropic hormone associated with pain
15) Confidence 0.61 Published 2004 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 15368903 Disease Relevance 0.27 Pain Relevance 0.53
Multiple afferent pathways underlie the control of adrenocorticotropin (ACTH).
Regulation (control) of ACTH
16) Confidence 0.61 Published 1985 Journal Fed. Proc. Section Abstract Doc Link 2981738 Disease Relevance 0 Pain Relevance 0.05
Multiple afferent pathways underlie the control of adrenocorticotropin (ACTH).
Regulation (control) of adrenocorticotropin
17) Confidence 0.61 Published 1985 Journal Fed. Proc. Section Abstract Doc Link 2981738 Disease Relevance 0 Pain Relevance 0.04
Pretreatment with methysergide, a SE receptor antagonist (3 X 2.8 mg orally, five men), did not induce any significant changes in plasma beta-EP and beta-LPH levels, but blocked the increase in the two hormones evoked by L5-OH-triptophan (40 mg iv).
Neg (not) Regulation (changes) of beta-LPH in plasma associated with antagonist and serotonin
18) Confidence 0.61 Published 1984 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6092410 Disease Relevance 0 Pain Relevance 0.33
A pharmacological approach was used to investigate the serotoninergic control of plasma levels on beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) in humans.
Spec (investigate) Regulation (control) of beta-endorphin in plasma
19) Confidence 0.61 Published 1984 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6092410 Disease Relevance 0 Pain Relevance 0.18
A pharmacological approach was used to investigate the serotoninergic control of plasma levels on beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) in humans.
Spec (investigate) Regulation (control) of beta-LPH in plasma
20) Confidence 0.61 Published 1984 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6092410 Disease Relevance 0 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox