INT73815

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Context Info
Confidence 0.80
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 1.73
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf1) cytoplasm (Fgf1) cytosol (Fgf1)
extracellular space (Fgf1) extracellular region (Fgf1) proteinaceous extracellular matrix (Fgf1)
Anatomy Link Frequency
neurons 1
brain 1
parasympathetic 1
Fgf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 9 100.00 Very High Very High Very High
Nerve growth factor 8 100.00 Very High Very High Very High
medulla 35 96.80 Very High Very High Very High
Intracerebroventricular 4 96.64 Very High Very High Very High
Central nervous system 29 89.76 High High
anesthesia 23 81.52 Quite High
Spinal cord 23 78.56 Quite High
midbrain 8 42.44 Quite Low
Neurotransmitter 2 37.24 Quite Low
Immobilon 5 15.48 Low Low
Disease Link Frequency Relevance Heat
Corneal Neovascularization 22 99.48 Very High Very High Very High
Injury 119 99.40 Very High Very High Very High
Disease 16 90.12 High High
Nervous System Injury 5 89.84 High High
Vibrio Infection 15 83.96 Quite High
Body Weight 10 83.44 Quite High
Spinal Cord Injury 63 57.16 Quite High
Rheumatoid Arthritis 6 31.72 Quite Low
Cancer 26 23.76 Low Low
Obesity 1 20.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since FGF1 is released from damaged neurons and acts as a trophic factor, the low expression of FGF1 in the DMNV may account for the susceptibility of preganglionic parasympathetic neurons to axonal injury.



Localization (released) of FGF1 in parasympathetic associated with injury
1) Confidence 0.80 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831852 Disease Relevance 0.46 Pain Relevance 0
Double immunofluorescence for FGF1 and CTb
Localization (immunofluorescence) of FGF1
2) Confidence 0.75 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831852 Disease Relevance 0.25 Pain Relevance 0.13
Double immunofluorescence for FGF1 and ChAT or pChAT
Localization (immunofluorescence) of FGF1
3) Confidence 0.75 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831852 Disease Relevance 0 Pain Relevance 0
For simultaneous visualization of FGF1 and CTb, we employed a double immunofluorescence method using the mouse anti-FGF1 antibody and goat anti-choleragenoid antibody.
Localization (visualization) of FGF1
4) Confidence 0.75 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831852 Disease Relevance 0.24 Pain Relevance 0.13
These findings suggest that intracerebroventricular administration of aFGF activates the hypothalamic-pituitary-adrenal axis via corticotropin-releasing factor release in the brain, whereas peripheral administration of aFGF activates adrenocortical secretion mainly via a direct action on ACTH release.
Localization (secretion) of aFGF in brain associated with intracerebroventricular
5) Confidence 0.71 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486310 Disease Relevance 0 Pain Relevance 0.15
Since FGF1 lacks the signal peptide, FGF1 is thought to be released upon cellular injury and to have a trophic effect on damaged neurons [3, 9].
Localization (released) of FGF1 in neurons associated with injury
6) Confidence 0.70 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831852 Disease Relevance 0.54 Pain Relevance 0
The precise cellular mechanisms underlying functional improvement after OEC transplantation are not fully understood; however OEC has been shown to secrete varying amounts of NGF, BDNF, GDNF, CNTF, FGF and VEGF, depending on culture conditions or in vivo microenvironment.
Localization (secrete) of FGF associated with nerve growth factor
7) Confidence 0.09 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3019362 Disease Relevance 0.15 Pain Relevance 0.13
Under conditions that support self-renewal (in the presence of FGF and FGF + Dll4, for 2 days), fetal NSCs express both Ang1 and Ang2.
Localization (presence) of FGF
8) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0 Pain Relevance 0.03
Under conditions that support self-renewal (in the presence of FGF and FGF + Dll4, for 2 days), fetal NSCs express both Ang1 and Ang2.
Localization (presence) of FGF
9) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0 Pain Relevance 0.03
Moreover, our findings may be due to the presence of other cytokines (transforming growth factor a and b2; TGF a and b1, and FGF involved in corneal neovascularization in addition to VEGF) [21].
Localization (presence) of FGF associated with corneal neovascularization and cytokine
10) Confidence 0.05 Published 2010 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2916105 Disease Relevance 0.10 Pain Relevance 0.10

General Comments

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