INT7383

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Context Info
Confidence 0.81
First Reported 1981
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 53
Total Number 54
Disease Relevance 17.70
Pain Relevance 22.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (VIP)
Anatomy Link Frequency
nerves 5
small intestine 4
neurons 4
colon 3
ileum 2
VIP (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 326 100.00 Very High Very High Very High
substance P 136 100.00 Very High Very High Very High
Enkephalin 80 100.00 Very High Very High Very High
Calcitonin gene-related peptide 35 100.00 Very High Very High Very High
Somatostatin 14 100.00 Very High Very High Very High
Opioid 13 100.00 Very High Very High Very High
Nerve growth factor 6 100.00 Very High Very High Very High
neuropeptide release 2 100.00 Very High Very High Very High
qutenza 80 99.82 Very High Very High Very High
Catecholamine 35 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 5 100.00 Very High Very High Very High
Stress 35 99.74 Very High Very High Very High
Cluster Headache 5 99.70 Very High Very High Very High
Carcinoma 7 99.64 Very High Very High Very High
Headache 14 99.56 Very High Very High Very High
Natriuresis 2 99.00 Very High Very High Very High
Psoriasis 30 98.96 Very High Very High Very High
Hypersensitivity 81 98.78 Very High Very High Very High
INFLAMMATION 116 98.18 Very High Very High Very High
Achalasia 316 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ruthenium red selectively antagonizes capsaicin-induced release of vasoactive intestinal polypeptide (VIP) from the human colon.
Localization (release) of VIP in colon associated with qutenza
1) Confidence 0.81 Published 1991 Journal Neurosci. Lett. Section Title Doc Link 1717894 Disease Relevance 0.08 Pain Relevance 0.76
The aim of this study was to assess whether RR is able to antagonize the release of vasoactive intestinal polypeptide (VIP) evoked by capsaicin in the human colon.
Localization (release) of VIP in colon associated with qutenza
2) Confidence 0.81 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1717894 Disease Relevance 0.09 Pain Relevance 0.49
VIP released from skin nerves induces keratinocyte hyperproliferation, angiogenesis, vasodilation, and other SPs-associated cutaneous pathological processes.
Localization (released) of VIP in nerves associated with psoriasis, pathologic processes and increased venous pressure under development
3) Confidence 0.80 Published 2009 Journal Med. Hypotheses Section Abstract Doc Link 18926642 Disease Relevance 0.88 Pain Relevance 0.32
A now 61-year old man with hypersecretion of vasoactive intestinal polypeptide (VIP) due to carcinoma of the tail of the pancreas was treated and followed for nine years.
Localization (hypersecretion) of VIP in pancreas associated with carcinoma
4) Confidence 0.78 Published 1986 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 2868874 Disease Relevance 0.23 Pain Relevance 0.03
Multiple mechanisms leading to VIP release exist in the human colon.
Localization (release) of VIP in colon
5) Confidence 0.71 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1717894 Disease Relevance 0.07 Pain Relevance 0.69
RR (10 microM) completely antagonized the capsaicin-induced release of VIP from muscle of human colon.
Localization (release) of VIP in muscle associated with qutenza
6) Confidence 0.71 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1717894 Disease Relevance 0.09 Pain Relevance 0.73
Autoradiographic localization of vasoactive intestinal peptide (VIP) binding sites in the human term placenta.
Localization (localization) of VIP in placenta
7) Confidence 0.70 Published 1987 Journal Regul. Pept. Section Title Doc Link 2829291 Disease Relevance 0 Pain Relevance 0.05
Thereby, a vicious circle-type mechanism perpetuating and amplifying VIP secretion can function in the focuses of psoriatic damage.
Localization (secretion) of VIP associated with psoriasis
8) Confidence 0.69 Published 2009 Journal Med. Hypotheses Section Abstract Doc Link 18926642 Disease Relevance 1.13 Pain Relevance 0.50
These can go on over a prolonged period since (1) once released, VIP induces its own further secretion; (2) VIP induces release of interleukin-6 (IL6) that evokes both its own further release and release of VIP.
Localization (release) of VIP
9) Confidence 0.69 Published 2009 Journal Med. Hypotheses Section Abstract Doc Link 18926642 Disease Relevance 1.12 Pain Relevance 0.49
The co-existence of pituitary hormone and neuropeptide secretion [growth hormone (GH), prolactin (PRL), adrenocorticotropic hormone (ACTH), thyroid stimulating hormone (TSH), triiodothyronine (T3), somatostatin, oxytocin (OT), follicle stimulating hormone (FSH), luteinizing hormone (LH), arginine vasopressin (AVP), growth hormone releasing hormone (GHRH), corticotropin releasing hormone (CRH), nerve growth factor (NGF), vasoactive intestinal peptide (VIP), pro-enkephalin (pro-enk), and beta-endorphin (beta-end)], as well as production of a number of interleukins and growth factors and expression of receptors for all, by RE cells is an unique molecular biological phenomenon.
Localization (secretion) of VIP in follicle associated with nerve growth factor, somatostatin, neuropeptide and enkephalin
10) Confidence 0.68 Published 2000 Journal Anticancer Res. Section Abstract Doc Link 10928121 Disease Relevance 0 Pain Relevance 0.30
PACAP 1-38 (10(-9) M) increased substance P (SP), gastrin releasing peptide (GRP) and VIP release.
Localization (release) of VIP associated with substance p
11) Confidence 0.68 Published 2001 Journal Regul. Pept. Section Abstract Doc Link 11495686 Disease Relevance 0 Pain Relevance 0.48
Exposure to capsaicin (1 microM) produced a prompt and sustained release of vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) from mucosa-free strips of human small intestine (jejunum and ileum).
Localization (release) of VIP in jejunum associated with qutenza
12) Confidence 0.68 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2786168 Disease Relevance 0 Pain Relevance 0.46
A variety of vasoactive substances including biogenic amines, neuropeptide Y, somatostatin, enkephalin, ACTH, corticotropin-releasing hormone, growth hormone releasing hormone, vasoactive intestinal peptide, calcitonin, and atrial natriuretic factor have been extracted from intra-adrenal and extra-adrenal pheochromocytomas in men.
Localization (releasing) of vasoactive intestinal peptide associated with natriuresis, somatostatin, neuropeptide, enkephalin and pheochromocytoma
13) Confidence 0.68 Published 1992 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 1348292 Disease Relevance 0.56 Pain Relevance 0.20
Moreover, the role of peptidergic receptors (VIP, CGRP, TKs, SP, ecc.; neuropeptide release from peripheral endings of capsaicin-sensitive nerves) has been suggested and investigations are in progress.
Localization (release) of VIP in nerves associated with qutenza and neuropeptide release
14) Confidence 0.68 Published 1991 Journal Minerva Urol Nefrol Section Abstract Doc Link 1812568 Disease Relevance 0 Pain Relevance 0.15
Release of vasoactive intestinal peptide by intraduodenal infusion of HCl or fat and intramuscular injection of neostigmine in man.
Localization (Release) of vasoactive intestinal peptide in fat
15) Confidence 0.62 Published 1985 Journal Hepatogastroenterology Section Title Doc Link 4018706 Disease Relevance 0.08 Pain Relevance 0.31
Either capsaicin or high K+ produced a prompt release of VIP.
Localization (release) of VIP associated with qutenza
16) Confidence 0.62 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1717894 Disease Relevance 0.09 Pain Relevance 0.72
This effect was elective, since VIP release evoked by high K+ was unaffected by the presence of RR.
Localization (release) of VIP
17) Confidence 0.62 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1717894 Disease Relevance 0.08 Pain Relevance 0.72
Possible triggering mechanisms for VIP release and its source are discussed.
Localization (release) of VIP
18) Confidence 0.62 Published 1986 Journal Gen. Pharmacol. Section Abstract Doc Link 3721187 Disease Relevance 0.17 Pain Relevance 0.23
Autoradiographic localization of vasoactive intestinal peptide (VIP) binding sites in the human term placenta.
Localization (localization) of vasoactive intestinal peptide in placenta
19) Confidence 0.61 Published 1987 Journal Regul. Pept. Section Title Doc Link 2829291 Disease Relevance 0 Pain Relevance 0
With the associated symptoms of nasal congestion and rhinorrhea, VIP is released.
Localization (released) of VIP in nasal
20) Confidence 0.61 Published 1995 Journal Cephalalgia Section Abstract Doc Link 7585922 Disease Relevance 0.27 Pain Relevance 0.84

General Comments

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