INT73833

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Context Info
Confidence 0.44
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.58
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ibsp) extracellular region (Ibsp) cell adhesion (Ibsp)
extracellular matrix organization (Ibsp)
Anatomy Link Frequency
stromal cells 1
knee joint 1
knee 1
Ibsp (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 9 98.16 Very High Very High Very High
Pain 5 96.84 Very High Very High Very High
Snapping jaw 10 50.00 Quite Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
cOX1 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 9 98.16 Very High Very High Very High
Osteoporosis 20 96.88 Very High Very High Very High
Pain 5 96.84 Very High Very High Very High
Pathologic Processes 1 93.24 High High
Temporomandibular Joint Syndrome 10 92.92 High High
Fracture Healing 64 83.04 Quite High
Hypercalcemia 8 68.88 Quite High
Postmenopausal Osteoporosis 5 50.00 Quite Low
Osteoporotic Fractures 6 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bone marrow-derived stromal cells in culture, when exposed to SR, displayed a significant increase in the expression of the master gene, Runx2, as well as bone sialoprotein (BSP), and this was associated with a significant increase in the formation of CFU-obs.
Gene_expression (expression) of BSP in stromal cells
1) Confidence 0.44 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.21 Pain Relevance 0
Results: In the control group, BMP-4, Runx2, and BSP expressions showed no definite difference at any stage.
Gene_expression (expressions) of BSP
2) Confidence 0.44 Published 2007 Journal Oral Dis Section Body Doc Link 17305626 Disease Relevance 0.09 Pain Relevance 0
We examined the significant alterations of the expression patterns of bone morphogenetic protein (BMP)-4, Runx2, and bone sialoprotein (BSP) after ovariectomy.
Gene_expression (expression) of BSP
3) Confidence 0.39 Published 2007 Journal Oral Dis Section Body Doc Link 17305626 Disease Relevance 0.09 Pain Relevance 0
IBSP showed an expression pattern different from that of the other matrix genes, with significant expression beginning at day 10, peaking at day 14, and continuing until day 42.
Gene_expression (expression) of IBSP
4) Confidence 0.23 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1578570 Disease Relevance 0.30 Pain Relevance 0
Serum levels of COMP and BSP were measured by immunoassays.
Gene_expression (levels) of BSP
5) Confidence 0.11 Published 1998 Journal Osteoarthr. Cartil. Section Body Doc Link 9616437 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: In individuals with knee pain, serum levels of COMP and BSP differ between those with or without bone scan abnormalities in the knee joints.
Gene_expression (levels) of BSP in knee
6) Confidence 0.11 Published 1998 Journal Osteoarthr. Cartil. Section Body Doc Link 9616437 Disease Relevance 0 Pain Relevance 0
Changes in serum levels of COMP and BSP are potential tools in studies of knee joint OA in subjects with chronic knee pain.
Gene_expression (levels) of BSP in knee joint associated with pain and osteoarthritis
7) Confidence 0.09 Published 1998 Journal Br. J. Rheumatol. Section Abstract Doc Link 9487250 Disease Relevance 0.89 Pain Relevance 0.51

General Comments

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