INT73836

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Context Info
Confidence 0.19
First Reported 1998
Last Reported 2006
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 4.20
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Comp) extracellular region (Comp) cell adhesion (Comp)
proteinaceous extracellular matrix (Comp) extracellular matrix organization (Comp)
Anatomy Link Frequency
knee joint 1
nodule 1
Comp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 321 99.98 Very High Very High Very High
rheumatoid arthritis 20 99.60 Very High Very High Very High
agonist 63 99.28 Very High Very High Very High
Osteoarthritis 21 97.84 Very High Very High Very High
Pain 5 96.52 Very High Very High Very High
gABA 24 76.16 Quite High
Pain scale 2 60.32 Quite High
Nucleus accumbens 15 50.00 Quite Low
GABAergic 30 5.00 Very Low Very Low Very Low
antagonist 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 22 100.00 Very High Very High Very High
Disease 12 98.04 Very High Very High Very High
Osteoarthritis 7 97.84 Very High Very High Very High
Pain 5 96.52 Very High Very High Very High
Pathologic Processes 1 93.92 High High
Knee Osteoarthritis 14 93.76 High High
Increased Venous Pressure Under Development 90 24.36 Low Low
Anaerobic Bacterial Infections 6 5.00 Very Low Very Low Very Low
Aids-related Complex 3 5.00 Very Low Very Low Very Low
Arrhythmias 2 Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in serum levels of COMP and BSP are potential tools in studies of knee joint OA in subjects with chronic knee pain.
Regulation (Changes) of COMP in knee joint associated with pain and osteoarthritis
1) Confidence 0.19 Published 1998 Journal Br. J. Rheumatol. Section Abstract Doc Link 9487250 Disease Relevance 0.89 Pain Relevance 0.51
The average value of the serum COMP level in RA patients was 10.4+/-3.6 U/l.
Regulation (value) of COMP associated with rheumatoid arthritis
2) Confidence 0.12 Published 2005 Journal Clin. Rheumatol. Section Abstract Doc Link 15940561 Disease Relevance 1.56 Pain Relevance 0.61
The influence of rheumatoid nodule presence on the serum COMP level was shown (p<0.05).
Regulation (influence) of COMP in nodule associated with rheumatoid arthritis
3) Confidence 0.12 Published 2005 Journal Clin. Rheumatol. Section Abstract Doc Link 15940561 Disease Relevance 1.75 Pain Relevance 0.70
In the majority of the experiments DA modulation of Comp1 was the largest, but in no experiment was the modulation or the multiple components the same.
Regulation (modulation) of Comp1 associated with dopamine
4) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0 Pain Relevance 0.28
In contrast, the D1 agonist SKF38393 facilitated Comp1 with no effect on Comp2' (Figure 7B2).
Neg (no) Regulation (effect) of Comp2 associated with agonist
5) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0 Pain Relevance 0.34
Exponential extrapolation of the decay of Comp1 and subtraction to isolate Comp2 (labeled 2') revealed that DA markedly attenuated Comp1, with little effect on Comp2' (Figure 7B1).
Neg (little) Regulation (effect) of Comp2 associated with dopamine
6) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0 Pain Relevance 0.34

General Comments

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