INT73841

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Context Info
Confidence 0.22
First Reported 1998
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.36
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CDC42BPG)
Anatomy Link Frequency
CHO 1
CDC42BPG (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 5 100.00 Very High Very High Very High
Dynorphin 1 98.16 Very High Very High Very High
opioid receptor 1 95.76 Very High Very High Very High
Opioid 4 95.44 Very High Very High Very High
agonist 8 95.16 Very High Very High Very High
antagonist 4 88.28 High High
fortral 2 83.60 Quite High
Immobilon 2 73.04 Quite High
mu opioid receptor 3 66.24 Quite High
MU agonist 1 58.96 Quite High
Disease Link Frequency Relevance Heat
Glioma 4 99.64 Very High Very High Very High
Bordatella Infection 2 56.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A C6 glioma cell line stably transfected with the human kappa opioid receptor (kappaOR) was used to characterize receptor binding and G protein activation via the kappaOR by a comprehensive series of opioid ligands.
Gene_expression (transfected) of kappaOR associated with kappa opioid receptor, opioid and glioma
1) Confidence 0.22 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918595 Disease Relevance 0.23 Pain Relevance 0.29
The results suggest that these cells express a homogeneous population of kappaOR, and that their [35S]GTPgammaS-binding properties make them an excellent means to assess kappaOR efficacy.
Gene_expression (express) of kappaOR
2) Confidence 0.22 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918595 Disease Relevance 0.13 Pain Relevance 0.41
The efficacies of different K agonists to activate K opioid receptor (kappaOR) and to induce acute homologous desensitization of kappaOR-mediated extracellular acidification response (ECAR) have been investigated using microphysiometry in Chinese hamster ovary (CHO) cells stably expressing kappaOR.
Gene_expression (expressing) of kappaOR in CHO associated with agonist and opioid receptor
3) Confidence 0.03 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9488166 Disease Relevance 0 Pain Relevance 0.35

General Comments

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