INT73849

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.40
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TSPO) mitochondrion (TSPO) aging (TSPO)
response to stress (TSPO)
Anatomy Link Frequency
cleavage 1
TSPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 2 96.62 Very High Very High Very High
rheumatoid arthritis 34 88.80 High High
cINOD 3 66.24 Quite High
Pain 30 61.44 Quite High
visual analogue scale 10 60.48 Quite High
Pain score 7 54.56 Quite High
anakinra 14 50.68 Quite High
antagonist 1 50.28 Quite High
Adalimumab 16 48.60 Quite Low
c fibre 11 48.56 Quite Low
Disease Link Frequency Relevance Heat
Bladder Disease 34 100.00 Very High Very High Very High
Targeted Disruption 57 98.32 Very High Very High Very High
Rheumatoid Arthritis 35 88.80 High High
Body Weight 2 88.16 High High
Disease 16 77.44 Quite High
Autoimmune Disease 1 67.80 Quite High
INFLAMMATION 23 66.00 Quite High
Pain 24 61.44 Quite High
Leukemia 1 57.28 Quite High
Amyloidosis 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antisense knockout vector was driven by the human enkephalin promoter, which contains two cAMP response elements, such that cAMP treatment of transfected cells could superinduce 18-kDa PBR antisense RNA transcription and, hence, down-regulate endogenous 18-kDa PBR mRNA levels.
Negative_regulation (down-regulate) of PBR mRNA associated with targeted disruption and enkephalin
1) Confidence 0.59 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9488670 Disease Relevance 0.51 Pain Relevance 0.10
At the level of cell proliferation, reduction of 18-kDa PBR mRNA showed no effect.
Negative_regulation (reduction) of PBR mRNA
2) Confidence 0.59 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9488670 Disease Relevance 0.42 Pain Relevance 0.06
The availability of cheaper generics was then supposed to have flow-on positive effects in decreasing PBS reimbursement of all products in such groups (despite the extent of brand premiums).
Negative_regulation (decreasing) of PBS
3) Confidence 0.30 Published 2007 Journal Aust New Zealand Health Policy Section Body Doc Link PMC1894805 Disease Relevance 0 Pain Relevance 0
Accurate prediction of pharmaceutical expenditure is critical if the PBS is to be sustained and limited resources allocated appropriately.
Negative_regulation (sustained) of PBS
4) Confidence 0.21 Published 2007 Journal Aust New Zealand Health Policy Section Body Doc Link PMC1828161 Disease Relevance 0.58 Pain Relevance 0.17
Compared to controls, a three- and five-fold increase of TRPM8-immunoreactive axons was seen in IDO and PBS groups respectively.
Negative_regulation (seen) of PBS associated with bladder disease
5) Confidence 0.03 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.73 Pain Relevance 0.15
Each well was washed several times with PBS, after which blots were incubated overnight with polyclonal anti-A?
Negative_regulation (washed) of PBS
6) Confidence 0.02 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0 Pain Relevance 0
In contrast to mCCRL2/L1.2 transfectants, however, at the 60-min time point there was a considerable reduction in surface-bound chemerin (Fig. 8 D, PBS wash), suggesting either eventual extracellular degradation or chemerin release.
Negative_regulation (reduction) of PBS
7) Confidence 0.01 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
The disruption of cortisol response corresponded with a significant reduction in transcript levels of the steroidogenic acute regulatory protein (StAR), but not peripheral-type benzodiazepine receptor, cytochrome P450 side-chain cleavage or 11beta-hydroxylase.
Negative_regulation (reduction) of benzodiazepine receptor in cleavage
8) Confidence 0.00 Published 2007 Journal Aquat. Toxicol. Section Abstract Doc Link 17889947 Disease Relevance 0.15 Pain Relevance 0.07

General Comments

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