INT73870

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Context Info
Confidence 0.47
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrbk1) aging (Adrbk1) cytoplasm (Adrbk1)
Anatomy Link Frequency
frontal cortex 2
Adrbk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methadone 5 99.98 Very High Very High Very High
Morphine 4 99.72 Very High Very High Very High
withdrawal 3 99.26 Very High Very High Very High
narcan 3 98.78 Very High Very High Very High
mu opioid receptor 1 90.96 High High
opiate 8 81.76 Quite High
tolerance 1 81.20 Quite High
addiction 1 80.32 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 99.52 Very High Very High Very High
Overdose 1 73.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spontaneous and naloxone-precipitated withdrawal after chronic morphine or methadone induced a marked up-regulation in the levels of total GRK2 in the rat frontal cortex (18-25%).
Positive_regulation (induced) of Regulation (regulation) of GRK2 in frontal cortex associated with narcan, urological neuroanatomy, methadone, withdrawal and morphine
1) Confidence 0.47 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9489748 Disease Relevance 0.17 Pain Relevance 1.66

General Comments

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