INT73872

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Context Info
Confidence 0.19
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.44
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brains 1
PDZK1IP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Desipramine 5 97.06 Very High Very High Very High
opiate 8 94.72 High High
Morphine 4 94.24 High High
methadone 5 93.28 High High
withdrawal 3 92.56 High High
narcan 3 91.60 High High
fluoxetine 1 84.56 Quite High
Inflammation 20 82.12 Quite High
antidepressant 6 79.44 Quite High
chemokine 2 73.80 Quite High
Disease Link Frequency Relevance Heat
Overdose 1 95.08 Very High Very High Very High
INFLAMMATION 22 82.12 Quite High
Urological Neuroanatomy 1 57.04 Quite High
Stress 14 5.00 Very Low Very Low Very Low
Apoptosis 10 5.00 Very Low Very Low Very Low
Glioblastoma 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Adenocarcinoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After 18 h of exposure, CLOM, DMI and NORF, but not TIAN, had biphasic effects on 1 microM isoprenaline-stimulated SPAP fsproduction with concentrations between 10 nM and 1 microM enhancing the maximal (E(max)) SPAP response, without changing EC50 values, but higher concentrations produced marked inhibitory effects.
Positive_regulation (enhancing) of SPAP associated with desipramine
1) Confidence 0.19 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17382299 Disease Relevance 0 Pain Relevance 0.40
In postmortem brains from human addicts, total GRK2 immunoreactivity was not changed significantly, but the level of the membrane-associated kinase was modestly but significantly increased (12%) compared with matched controls.
Positive_regulation (increased) of membrane-associated in brains
2) Confidence 0.02 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9489748 Disease Relevance 0.15 Pain Relevance 1.48
Further, Herpud1/ Herp, a membrane-associated protein which functions in ER associated degradation was upregulated 9.7-fold (Fig. 3A).
Positive_regulation (functions) of membrane-associated protein
3) Confidence 0.01 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.14 Pain Relevance 0.19
Further, Herpud1/ Herp, a membrane-associated protein which functions in ER associated degradation was upregulated 9.7-fold (Fig. 3A).
Positive_regulation (upregulated) of membrane-associated protein
4) Confidence 0.01 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.14 Pain Relevance 0.19

General Comments

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