INT739

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2011
Negated 11
Speculated 7
Reported most in Abstract
Documents 358
Total Number 365
Disease Relevance 102.28
Pain Relevance 166.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
plasma 72
pituitary 11
CSF 7
neurons 6
substantia nigra 5
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 761 100.00 Very High Very High Very High
Opioid 422 100.00 Very High Very High Very High
Pain 306 100.00 Very High Very High Very High
agonist 256 100.00 Very High Very High Very High
narcan 190 100.00 Very High Very High Very High
Morphine 119 100.00 Very High Very High Very High
opiate 115 100.00 Very High Very High Very High
substance P 98 100.00 Very High Very High Very High
Clonidine 93 100.00 Very High Very High Very High
Neuropeptide 70 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 497 100.00 Very High Very High Very High
Pain 312 100.00 Very High Very High Very High
Cancer 284 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 30 100.00 Very High Very High Very High
Frailty 22 100.00 Very High Very High Very High
Headache 31 99.96 Very High Very High Very High
Disease 386 99.92 Very High Very High Very High
Shock 12 99.92 Very High Very High Very High
Parkinson's Disease 33 99.90 Very High Very High Very High
Pigment Disorder 10 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After CRH test, rapid ACTH test and continuous ACTH test, he was diagnosed as having ACTH deficiency, and he was treated with steroids.
Negative_regulation (deficiency) of ACTH
1) Confidence 0.59 Published 2002 Journal Masui Section Abstract Doc Link 12134656 Disease Relevance 0.63 Pain Relevance 0.29
[A case of adrenocorticotropic hormone (ACTH) deficiency].
Negative_regulation (deficiency) of ACTH
2) Confidence 0.59 Published 2002 Journal Masui Section Title Doc Link 12134656 Disease Relevance 0.63 Pain Relevance 0.32
Endocrinological findings revealed no abnormalities except for a slight decrease in serum adrenocorticotropic hormone (ACTH), a slight increase in urine 17-ketosteroid (17-KS), and a marked increase in serum pregnenolone.
Neg (except) Negative_regulation (decrease) of ACTH in urine associated with congenital anomalies
3) Confidence 0.59 Published 1991 Journal Hinyokika Kiyo Section Abstract Doc Link 1648874 Disease Relevance 0.70 Pain Relevance 0.14
Plasma ACTH and cortisol were significantly suppressed 7 days after the first ESI; the group receiving midazolam was more suppressed.
Negative_regulation (suppressed) of ACTH in Plasma associated with versed
4) Confidence 0.59 Published 1994 Journal Anesth. Analg. Section Abstract Doc Link 8067555 Disease Relevance 0.18 Pain Relevance 0.33
At 48 days after the first ESI (34 days after the third ESI), plasma ACTH and cortisol were significantly suppressed only in the group that had received midazolam before each ESI.
Negative_regulation (suppressed) of ACTH in plasma associated with versed
5) Confidence 0.59 Published 1994 Journal Anesth. Analg. Section Abstract Doc Link 8067555 Disease Relevance 0.22 Pain Relevance 0.35
By 14 days after the first ESI (7 days after the second ESI), plasma ACTH was more suppressed in the group receiving midazolam and plasma cortisol was markedly suppressed in both groups.
Negative_regulation (suppressed) of ACTH in plasma associated with versed
6) Confidence 0.59 Published 1994 Journal Anesth. Analg. Section Abstract Doc Link 8067555 Disease Relevance 0.16 Pain Relevance 0.33
Before metyrapone administration the basal levels of cortisol and ACTH were significantly decreased in addicts as compared to normal controls, while plasma beta-endorphin was not different.
Negative_regulation (decreased) of ACTH in plasma
7) Confidence 0.59 Published 1990 Journal Neuropeptides Section Abstract Doc Link 2174517 Disease Relevance 0 Pain Relevance 0.29
A significant decrease of beta-endorphin plasma levels was observed 120 minutes after melatonin injection.
Negative_regulation (decrease) of beta-endorphin in plasma
8) Confidence 0.59 Published 1986 Journal J. Neural Transm. Section Abstract Doc Link 2937880 Disease Relevance 0 Pain Relevance 0.40
While a few cases of isolated ACTH deficiency have been reported (OMIM 201400), an inherited POMC defect has not been described so far.
Negative_regulation (deficiency) of ACTH
9) Confidence 0.59 Published 1998 Journal Nat. Genet. Section Abstract Doc Link 9620771 Disease Relevance 0.35 Pain Relevance 0.10
Highly significant decreases in Met-enkephalin, dopamine and noradrenaline levels were observed in the substantia nigra and ventral tegmental area of Parkinsonian brains.
Negative_regulation (decreases) of Met-enkephalin in brains associated with parkinson's disease, ventral tegmentum, dopamine, substantia nigra, noradrenaline and enkephalin
10) Confidence 0.59 Published 1982 Journal Brain Res. Section Abstract Doc Link 7188329 Disease Relevance 0.17 Pain Relevance 1.39
[A case of isolated ACTH deficiency with dementia].
Negative_regulation (deficiency) of ACTH associated with dementia
11) Confidence 0.59 Published 1994 Journal Nippon Naibunpi Gakkai Zasshi Section Title Doc Link 7851624 Disease Relevance 0.65 Pain Relevance 0.09
However, it has also been observed that habitual alcohol consumption leads to a beta-endorphin deficiency.
Negative_regulation (deficiency) of beta-endorphin associated with alcohol
12) Confidence 0.59 Published 2005 Journal Peptides Section Abstract Doc Link 15752586 Disease Relevance 0.25 Pain Relevance 0.50
Dexamethasone administration failed to suppress plasma beta-endorphin levels in untreated obese patients, but this finding has been reported in normal subjects in whom a similar assay methodology was used; it suppressed plasma cortisol levels in 29 of 32.
Neg (failed) Negative_regulation (suppress) of beta-endorphin in plasma associated with obesity and dexamethasone
13) Confidence 0.59 Published 1984 Journal Psychosom Med Section Abstract Doc Link 6093183 Disease Relevance 0.87 Pain Relevance 0.17
Plasma ACTH and cortisol levels were not lowered significantly more by clonidine than by placebo. 4.
Neg (not) Negative_regulation (lowered) of ACTH in Plasma associated with clonidine
14) Confidence 0.59 Published 1988 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 2856056 Disease Relevance 0.17 Pain Relevance 1.19
Plasma beta-endorphin levels decreased significantly (p less than 0.005) after intrathecal morphine from 76 +/- 9.7 to 46.3 +/- 9.1 fmol/ml (mean +/- SE), possibly because of decreased pituitary beta-endorphin secretion in response to alleviation of labor pain.
Spec (possibly) Negative_regulation (decreased) of beta-endorphin in Plasma associated with pain labor, morphine and intrathecal
15) Confidence 0.59 Published 1984 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 6087663 Disease Relevance 0.09 Pain Relevance 0.53
In 6 normal subjects, basal ACTH and cortisol plasma levels were significantly suppressed 3 h after loperamide administration (16 mg, orally) from 5 +/- 0 to 2 +/- 0 pmol/l and from 356 +/- 44 to 154 +/- 16 nmol/l.
Negative_regulation (suppressed) of ACTH in plasma
16) Confidence 0.59 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8090278 Disease Relevance 0.09 Pain Relevance 0.53
After stimulation with 8 ng ceruletide/kg body weight/min over a period of 5 min, the maximum ACTH levels (at 7.5 min) were significantly reduced by loperamide from 26 +/- 7 to 6 +/- 1 pmol/l and the maximum cortisol levels (at 30 min) were significantly reduced from 676 +/- 47 to 392 +/- 58 nmol/l.
Negative_regulation (reduced) of ACTH in body associated with body weight
17) Confidence 0.59 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8090278 Disease Relevance 0.10 Pain Relevance 0.48
In summary, loperamide is able to reduce basal and CRH-induced ACTH and cortisol levels in normal subjects, but not in patients with Cushing's disease or secondary adrenal failure of hypothalamic origin.
Neg (not) Negative_regulation (reduce) of ACTH associated with disease
18) Confidence 0.59 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1322429 Disease Relevance 0.61 Pain Relevance 0
Loperamide, an opiate agonist of high specificity for mu-receptors, was recently reported to suppress ACTH and cortisol levels in normal subjects, but not in patients with proven ACTH-dependent Cushing's disease.
Negative_regulation (suppress) of ACTH associated with agonist, opiate and disease
19) Confidence 0.59 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1322429 Disease Relevance 0.10 Pain Relevance 0.15
In seven normal subjects, basal ACTH plasma levels were significantly suppressed 3 h after loperamide administration (16 mg, orally) from 5 +/- 1 to 2 +/- 0 pmol/L (P less than 0.0001).
Negative_regulation (suppressed) of ACTH in plasma
20) Confidence 0.59 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1322429 Disease Relevance 0.15 Pain Relevance 0.12

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