INT73901

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Context Info
Confidence 0.53
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.46
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
T lymphocytes 2
PBMC 2
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
IPN 8 100.00 Very High Very High Very High
cytokine 3 100.00 Very High Very High Very High
diclofenac 3 98.16 Very High Very High Very High
cINOD 6 85.40 High High
Inflammation 23 84.80 Quite High
antagonist 2 81.36 Quite High
Antinociceptive 1 71.28 Quite High
Potency 2 62.32 Quite High
rheumatoid arthritis 11 50.00 Quite Low
Arthritis 31 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 25 84.80 Quite High
Adhesions 2 75.00 Quite High
Rheumatoid Arthritis 11 50.00 Quite Low
Arthritis 35 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 20 5.00 Very Low Very Low Very Low
Synovitis 12 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Hypercalcemia 5 5.00 Very Low Very Low Very Low
Experimental Arthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mofezolac suppressed the mRNA expression for IL-1 beta in PBMC stimulated with exogenous IL-1 beta, indicating the secreted IL-1ra in the presence of mofezolac to be biologically active.
Negative_regulation (suppressed) of Transcription (expression) of IL-1 in PBMC
1) Confidence 0.53 Published 1997 Journal Prostaglandins Section Abstract Doc Link 9491209 Disease Relevance 0.24 Pain Relevance 0.76
Monocytic IL-1beta mRNA expression in IPN samples without antibody pretreatment was highest at 2 h and decreased over time.
Negative_regulation (decreased) of Transcription (expression) of IL-1beta associated with ipn
2) Confidence 0.23 Published 2007 Journal J Biomater Sci Polym Ed Section Abstract Doc Link 17623553 Disease Relevance 0.15 Pain Relevance 0.66
MP acts at the G1 phase by inhibiting cytokine gene transcription in antigen presenting cells (eg, IL-1) and T lymphocytes (eg, IL-2).
Negative_regulation (inhibiting) of Transcription (transcription) of IL-1 in T lymphocytes associated with cytokine
3) Confidence 0.04 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626937 Disease Relevance 0.08 Pain Relevance 0.15

General Comments

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