INT73902

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Context Info
Confidence 0.61
First Reported 1997
Last Reported 2010
Negated 1
Speculated 5
Reported most in Abstract
Documents 6
Total Number 11
Disease Relevance 4.59
Pain Relevance 6.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RN) extracellular region (IL1RN) plasma membrane (IL1RN)
nucleus (IL1RN) intracellular (IL1RN) cytoplasm (IL1RN)
Anatomy Link Frequency
blood 8
plasma 2
chondrocytes 2
mononuclear cells 2
IL1RN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 22 100.00 Very High Very High Very High
cINOD 16 100.00 Very High Very High Very High
noradrenaline 10 100.00 Very High Very High Very High
diclofenac 9 100.00 Very High Very High Very High
Clonidine 4 100.00 Very High Very High Very High
aspirin 2 100.00 Very High Very High Very High
agonist 2 100.00 Very High Very High Very High
Inflammatory response 3 99.76 Very High Very High Very High
cytokine 73 99.56 Very High Very High Very High
Pain 6 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 45 100.00 Very High Very High Very High
Polymyalgia Rheumatica 38 99.88 Very High Very High Very High
Pain 8 97.96 Very High Very High Very High
Necrosis 8 96.60 Very High Very High Very High
Cancer 8 96.24 Very High Very High Very High
Recurrence 4 95.68 Very High Very High Very High
Disease 27 94.00 High High
Influenza Virus Infection 15 86.88 High High
Rheumatoid Arthritis 9 81.68 Quite High
Critical Illness 37 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of nonsteroidal anti-inflammatory drugs (NSAIDs), mofezolac, indomethacin, sodium diclofenac, and zaltoprofen, on the production of interleukin-1 receptor antagonist (IL-1ra) were examined in cultured human peripheral blood mononuclear cells (PBMC).
Spec (examined) Regulation (effects) of in blood Gene_expression (production) of interleukin-1 receptor antagonist in mononuclear cells associated with inflammation, antagonist, cinod and diclofenac
1) Confidence 0.61 Published 1997 Journal Prostaglandins Section Abstract Doc Link 9491209 Disease Relevance 0.17 Pain Relevance 0.58
We investigated the possible effects of 3 different nonsteroidal antiinflammatory drugs (NSAID; aceclofenac, piroxicam, aspirin) on IL-1Ra and NO production in human articular chondrocytes.
Spec (possible) Regulation (effects) of Neg (NO) Gene_expression (production) of IL-1Ra in chondrocytes associated with aspirin, inflammation and cinod
2) Confidence 0.58 Published 2001 Journal J. Rheumatol. Section Abstract Doc Link 11764219 Disease Relevance 0.20 Pain Relevance 0.28
The effects of nonsteroidal anti-inflammatory drugs (NSAIDs), mofezolac, indomethacin, sodium diclofenac, and zaltoprofen, on the production of interleukin-1 receptor antagonist (IL-1ra) were examined in cultured human peripheral blood mononuclear cells (PBMC).
Spec (examined) Regulation (effects) of in blood Gene_expression (production) of IL-1ra in mononuclear cells associated with inflammation, antagonist, cinod and diclofenac
3) Confidence 0.45 Published 1997 Journal Prostaglandins Section Abstract Doc Link 9491209 Disease Relevance 0.17 Pain Relevance 0.58
The production of IL-1 and IL-1ra is regulated by genotypic and nongenotypic factors and is different between men and women.
Regulation (regulated) of Gene_expression (production) of IL-1ra
4) Confidence 0.45 Published 2007 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 18052726 Disease Relevance 0.10 Pain Relevance 0.19
The present study was carried out in order to examine the effects of noradrenaline (10(-5), 10(-6) and 10(-7) M), clonidine (10(-5), 10(-6) and 10(-7) M), an alpha2-adrenoceptor agonist, and yohimbine (10(-5), 10(-6) and 10(-7) M), an alpha 2-adrenoceptor antagonist, on the production of IL-6, the IL-1 receptor antagonist (IL-1RA) and TNF alpha by stimulated whole blood of normal humans.
Spec (examine) Regulation (effects) of Gene_expression (production) of IL-1RA in blood associated with antagonist, agonist, noradrenaline and clonidine
5) Confidence 0.39 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 11084220 Disease Relevance 0.19 Pain Relevance 0.60
The present study was carried out in order to examine the effects of noradrenaline (10(-5), 10(-6) and 10(-7) M), clonidine (10(-5), 10(-6) and 10(-7) M), an alpha2-adrenoceptor agonist, and yohimbine (10(-5), 10(-6) and 10(-7) M), an alpha 2-adrenoceptor antagonist, on the production of IL-6, the IL-1 receptor antagonist (IL-1RA) and TNF alpha by stimulated whole blood of normal humans.
Spec (examine) Regulation (effects) of Gene_expression (production) of IL-1 receptor antagonist in blood associated with antagonist, agonist, noradrenaline and clonidine
6) Confidence 0.39 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 11084220 Disease Relevance 0.19 Pain Relevance 0.60
Influence of the IL-1 receptor antagonist gene
Regulation (Influence) of Gene_expression (gene) of IL-1 receptor antagonist associated with antagonist
7) Confidence 0.32 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128892 Disease Relevance 1.20 Pain Relevance 0.31
Effects of nonsteroidal anti-inflammatory drugs on interleukin-1 receptor antagonist production in cultured human peripheral blood mononuclear cells.
Regulation (Effects) of Gene_expression (production) of interleukin-1 receptor antagonist in blood associated with inflammation, antagonist and cinod
8) Confidence 0.27 Published 1997 Journal Prostaglandins Section Title Doc Link 9491209 Disease Relevance 0.26 Pain Relevance 0.78
Since IL-1Ra polymorphism is known to affect the levels of both IL-1Ra and IL-1, cytokines associated with modulation of pain sensitivity and morphine analgesia, it is suggested that IL-1Ra genetic polymorphism may contribute to the variation in postoperative morphine consumption.
Regulation (affect) of Gene_expression (levels) of IL-1Ra associated with pain, analgesia, morphine and cytokine
9) Confidence 0.23 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16777324 Disease Relevance 0.40 Pain Relevance 1.43
IL6 is known to be responsible for regulating plasma levels of IL1RA and IL10 [16].
Regulation (regulating) of Gene_expression (levels) of IL1RA in plasma
10) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.09 Pain Relevance 0.34
The intraarticular availability of adequate levels of IL-1ra is important, as IL-1?
Regulation (availability) of Gene_expression (levels) of IL-1ra
11) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911907 Disease Relevance 0.61 Pain Relevance 0.44

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