INT73904

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 1998
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.50
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RN) extracellular region (IL1RN) plasma membrane (IL1RN)
nucleus (IL1RN) intracellular (IL1RN) cytoplasm (IL1RN)
Anatomy Link Frequency
blood 4
Discal cells 2
PBMC 2
IL1RN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 6 100.00 Very High Very High Very High
cytokine 14 97.16 Very High Very High Very High
Inflammation 6 96.32 Very High Very High Very High
diclofenac 3 95.80 Very High Very High Very High
cINOD 5 93.20 High High
Sciatica 1 86.92 High High
Antinociceptive 1 55.28 Quite High
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Necrosis 2 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Injury 2 99.76 Very High Very High Very High
Sepsis 2 99.32 Very High Very High Very High
Bacterial Infection 2 97.56 Very High Very High Very High
INFLAMMATION 8 96.32 Very High Very High Very High
Nerve Root Compression 1 86.92 High High
Endotoxemia 2 35.60 Quite Low
Myalgia 2 25.00 Low Low
Intervertebral Disk Degeneration 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These two drugs also stimulated the secretion of IL-1ra by PBMC in the absence of bacterial lipopolysaccharide (LPS), however, the stimulatory effect of sodium diclofenac diminished in the presence of LPS.
Positive_regulation (stimulated) of Localization (secretion) of IL-1ra in PBMC associated with diclofenac
1) Confidence 0.69 Published 1997 Journal Prostaglandins Section Abstract Doc Link 9491209 Disease Relevance 0.23 Pain Relevance 0.75
Discal cells were isolated, cultures and culture supernatants immunochemically analysed for IL-1beta and IL-1Ra secretion.
Spec (analysed) Positive_regulation (analysed) of Spec (analysed) Localization (secretion) of IL-1Ra in Discal cells
2) Confidence 0.47 Published 1998 Journal Cytokine Section Abstract Doc Link 9770331 Disease Relevance 0.09 Pain Relevance 0.20
The sequential release of tumour necrosis factor-alpha, interleukin (IL) 1 beta, IL-6, and IL-1 receptor antagonist (IL-1ra) in the blood is comparable to that observed in relation to bacterial diseases.
Positive_regulation (sequential) of Localization (release) of IL-1ra in blood associated with necrosis, cancer, antagonist and bacterial infection
3) Confidence 0.08 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9839076 Disease Relevance 0.59 Pain Relevance 0.22
The sequential release of tumour necrosis factor-alpha, interleukin (IL) 1 beta, IL-6, and IL-1 receptor antagonist (IL-1ra) in the blood is comparable to that observed in relation to bacterial diseases.
Positive_regulation (sequential) of Localization (release) of IL-1 receptor antagonist in blood associated with necrosis, cancer, antagonist and bacterial infection
4) Confidence 0.08 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9839076 Disease Relevance 0.59 Pain Relevance 0.22

General Comments

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