INT73905

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Context Info
Confidence 0.71
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 9.16
Pain Relevance 5.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RN) extracellular region (IL1RN) plasma membrane (IL1RN)
nucleus (IL1RN) intracellular (IL1RN) cytoplasm (IL1RN)
Anatomy Link Frequency
joint 3
shoulder 3
macrophage 1
IL1RN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 30 100.00 Very High Very High Very High
diclofenac 3 99.32 Very High Very High Very High
cINOD 7 98.52 Very High Very High Very High
shoulder pain 30 98.08 Very High Very High Very High
Arthritis 102 97.84 Very High Very High Very High
Inflammation 124 96.44 Very High Very High Very High
chemokine 31 89.64 High High
cytokine 116 89.20 High High
rheumatoid arthritis 185 84.00 Quite High
visual analogue scale 6 65.20 Quite High
Disease Link Frequency Relevance Heat
Shoulder Pain 30 98.08 Very High Very High Very High
Experimental Arthritis 27 97.84 Very High Very High Very High
Disease 90 97.68 Very High Very High Very High
INFLAMMATION 127 96.44 Very High Very High Very High
Synovitis 33 94.92 High High
Rheumatoid Arthritis 187 84.00 Quite High
Herpes Simplex Virus 2 78.00 Quite High
Arthritis 48 75.96 Quite High
Cancer 16 67.12 Quite High
Necrosis 16 66.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the NSAIDs tested, mofezolac and sodium diclofenac were found to stimulate the mRNA expression for IL-1ra without affecting the mRNA expression for IL-1 beta.
Transcription (expression) of IL-1ra associated with cinod and diclofenac
1) Confidence 0.71 Published 1997 Journal Prostaglandins Section Abstract Doc Link 9491209 Disease Relevance 0.22 Pain Relevance 0.69
The present study was undertaken to determine the relationship between mRNA expression levels of IL-1beta and its receptor antagonists (secreted interleukin-1 receptor antagonist (IL-1ra) and intracellular IL-1ra) in the synovium of the glenohumeral joint and shoulder pain in rotator cuff diseases, analyzing the synovial specimens by reverse transcriptase polymerase chain reaction.
Transcription (levels) of interleukin-1 receptor antagonist in shoulder associated with antagonist, shoulder pain and disease
2) Confidence 0.39 Published 2002 Journal J. Orthop. Res. Section Abstract Doc Link 12472254 Disease Relevance 1.16 Pain Relevance 0.61
The present study was undertaken to determine the relationship between mRNA expression levels of IL-1beta and its receptor antagonists (secreted interleukin-1 receptor antagonist (IL-1ra) and intracellular IL-1ra) in the synovium of the glenohumeral joint and shoulder pain in rotator cuff diseases, analyzing the synovial specimens by reverse transcriptase polymerase chain reaction.
Transcription (levels) of IL-1ra in shoulder associated with antagonist, shoulder pain and disease
3) Confidence 0.39 Published 2002 Journal J. Orthop. Res. Section Abstract Doc Link 12472254 Disease Relevance 1.16 Pain Relevance 0.61
The present study was undertaken to determine the relationship between mRNA expression levels of IL-1beta and its receptor antagonists (secreted interleukin-1 receptor antagonist (IL-1ra) and intracellular IL-1ra) in the synovium of the glenohumeral joint and shoulder pain in rotator cuff diseases, analyzing the synovial specimens by reverse transcriptase polymerase chain reaction.
Transcription (levels) of IL-1ra in shoulder associated with antagonist, shoulder pain and disease
4) Confidence 0.39 Published 2002 Journal J. Orthop. Res. Section Abstract Doc Link 12472254 Disease Relevance 1.17 Pain Relevance 0.64
The present study was undertaken to determine the relationship between mRNA expression levels of IL-1beta and its receptor antagonists (secreted interleukin-1 receptor antagonist (IL-1ra) and intracellular IL-1ra) in the synovium of the glenohumeral joint and shoulder pain in rotator cuff diseases, analyzing the synovial specimens by reverse transcriptase polymerase chain reaction.
Transcription (levels) of IL-1ra in joint associated with antagonist, shoulder pain and disease
5) Confidence 0.13 Published 2002 Journal J. Orthop. Res. Section Abstract Doc Link 12472254 Disease Relevance 1.17 Pain Relevance 0.64
The present study was undertaken to determine the relationship between mRNA expression levels of IL-1beta and its receptor antagonists (secreted interleukin-1 receptor antagonist (IL-1ra) and intracellular IL-1ra) in the synovium of the glenohumeral joint and shoulder pain in rotator cuff diseases, analyzing the synovial specimens by reverse transcriptase polymerase chain reaction.
Transcription (levels) of IL-1ra in joint associated with antagonist, shoulder pain and disease
6) Confidence 0.13 Published 2002 Journal J. Orthop. Res. Section Abstract Doc Link 12472254 Disease Relevance 1.16 Pain Relevance 0.61
The present study was undertaken to determine the relationship between mRNA expression levels of IL-1beta and its receptor antagonists (secreted interleukin-1 receptor antagonist (IL-1ra) and intracellular IL-1ra) in the synovium of the glenohumeral joint and shoulder pain in rotator cuff diseases, analyzing the synovial specimens by reverse transcriptase polymerase chain reaction.
Transcription (levels) of interleukin-1 receptor antagonist in joint associated with antagonist, shoulder pain and disease
7) Confidence 0.13 Published 2002 Journal J. Orthop. Res. Section Abstract Doc Link 12472254 Disease Relevance 1.16 Pain Relevance 0.61
AP-1 = activator protein-1; CRP = C-reactive protein; GM-CSF = granulocyte macrophage colony-stimulating factor; IFN = interferon; IL = interleukin; IL-1RA = interleukin-1 receptor antagonist; LPS = lipopolysaccharide; M?
Transcription (antagonist) of IL-1RA in macrophage associated with antagonist
8) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.91 Pain Relevance 0.18
or to deliver/overexpress protective IL-1RA, soluble IL-1 type I receptor-IgG fusion protein, and type I soluble TNF-?
Transcription (deliver) of IL-1RA
9) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.80 Pain Relevance 0.36
, IL-1Ra, IL-6 SF levels as well as between ESR and IL-1?
Transcription (levels) of IL-1Ra
10) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945042 Disease Relevance 0.25 Pain Relevance 0.09

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