INT73906

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Context Info
Confidence 0.56
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.46
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
IPN 8 99.44 Very High Very High Very High
Inflammatory mediators 2 99.08 Very High Very High Very High
Inflammation 27 98.94 Very High Very High Very High
diclofenac 3 98.72 Very High Very High Very High
cINOD 5 97.92 Very High Very High Very High
antagonist 14 91.80 High High
Arthritis 1 89.64 High High
Pain 2 85.32 High High
cytokine 10 81.88 Quite High
Snapping jaw 4 69.84 Quite High
Disease Link Frequency Relevance Heat
Neointima 1 100.00 Very High Very High Very High
Disease 10 99.10 Very High Very High Very High
INFLAMMATION 35 98.94 Very High Very High Very High
Obesity 104 93.68 High High
Adhesions 2 92.80 High High
Arthritis 2 89.64 High High
Cerebral Malaria 51 87.60 High High
Targeted Disruption 2 87.20 High High
Pain 2 85.32 High High
Malaria 23 76.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the NSAIDs tested, mofezolac and sodium diclofenac were found to stimulate the mRNA expression for IL-1ra without affecting the mRNA expression for IL-1 beta.
Neg (without) Regulation (affecting) of Transcription (expression) of IL-1 associated with cinod and diclofenac
1) Confidence 0.56 Published 1997 Journal Prostaglandins Section Abstract Doc Link 9491209 Disease Relevance 0.23 Pain Relevance 0.74
The impact-loading induced the expression of IL-1beta immunohistochemically and prominently up-regulated IL-1alpha and IL-1beta mRNA levels in subchondral bone.
Regulation (regulated) of Transcription (levels) of IL-1beta
2) Confidence 0.44 Published 2009 Journal Ann Biomed Eng Section Abstract Doc Link 19381811 Disease Relevance 0.35 Pain Relevance 0.25
Recently, Kimura et al. [11] employed allele-specific transcript quantification to examine the effects of IL1B -31C>T and 3953C>T polymorphisms on the level of IL-1B transcription.
Spec (examine) Regulation (effects) of Transcription (transcription) of IL-1B
3) Confidence 0.27 Published 2005 Journal Malar J Section Body Doc Link PMC1224865 Disease Relevance 0.49 Pain Relevance 0.06
The change in IL-1beta mRNA expression did not correlate with changes in protein expression.
Regulation (change) of Transcription (expression) of IL-1beta
4) Confidence 0.14 Published 2007 Journal J Biomater Sci Polym Ed Section Abstract Doc Link 17623553 Disease Relevance 0.17 Pain Relevance 0.54
Further investigations on the effect of leptin on the expression of inflammatory mediators indicated that the adipokine was not able to modulate the mRNA level of iNOS and IL-1.
Regulation (modulate) of Transcription (level) of IL-1 associated with inflammatory mediators
5) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.08 Pain Relevance 0.10
Conversely, some IL-1-driven inflammatory disease models refute a role for the P2X7 receptor; IL-1-mediated neointima formation is unaltered in P2X7 receptor-deficient mice (54).
Regulation (unaltered) of Transcription (formation) of IL-1-mediated associated with inflammation, neointima and disease
6) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 1.15 Pain Relevance 0.41

General Comments

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