INT73913

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.24
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Esr1) nucleus (Esr1) enzyme binding (Esr1)
DNA binding (Esr1) protein complex (Esr1) transcription factor binding (Esr1)
Anatomy Link Frequency
temporomandibular joint 2
Esr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 2 100.00 Very High Very High Very High
Inflammation 30 99.98 Very High Very High Very High
Cholecystokinin 5 99.92 Very High Very High Very High
Snapping jaw 94 99.68 Very High Very High Very High
Central nervous system 1 93.56 High High
Neuropeptide 1 85.96 High High
endometriosis 4 50.00 Quite Low
Pain 6 10.00 Low Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 30 99.98 Very High Very High Very High
Temporomandibular Joint Syndrome 92 99.68 Very High Very High Very High
Endometriosis (extended) 4 87.28 High High
Pain 4 86.28 High High
Lordosis 1 81.68 Quite High
Pressure And Volume Under Development 8 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interaction of thyroxine and estrogen on the expression of estrogen receptor alpha, cholecystokinin, and preproenkephalin messenger ribonucleic acid in the limbic-hypothalamic circuit.
Regulation (Interaction) of Gene_expression (expression) of estrogen receptor alpha associated with enkephalin and cholecystokinin
1) Confidence 0.41 Published 1998 Journal Endocrinology Section Title Doc Link 9492057 Disease Relevance 0.08 Pain Relevance 0.44
Estrogen and inflammation modulate estrogen receptor alpha expression in specific tissues of the temporomandibular joint

Background

Regulation (modulate) of Gene_expression (expression) of estrogen receptor in temporomandibular joint associated with snapping jaw and inflammation
2) Confidence 0.25 Published 2009 Journal Reprod Biol Endocrinol Section Title Doc Link PMC2811708 Disease Relevance 1.02 Pain Relevance 0.89
In conclusion, inflammation and 17 beta-estradiol can modulate ERalpha expression in the TMJ but the effects are tissue specific.



Regulation (modulate) of Gene_expression (expression) of ERalpha associated with snapping jaw and inflammation
3) Confidence 0.25 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2811708 Disease Relevance 0.79 Pain Relevance 0.59
Changes in the expression of proliferating cell nuclear antigen, Fas, progesterone receptor (PRA) and estrogen receptor alpha (ER-alpha) were analyzed by immunohistochemistry.
Regulation (Changes) of Spec (analyzed) Gene_expression (expression) of ER-alpha
4) Confidence 0.08 Published 2009 Journal Hum. Reprod. Section Body Doc Link 19661125 Disease Relevance 0.17 Pain Relevance 0
Changes in the expression of proliferating cell nuclear antigen, Fas, progesterone receptor (PRA) and estrogen receptor alpha (ER-alpha) were analyzed by immunohistochemistry.
Regulation (Changes) of Spec (analyzed) Gene_expression (expression) of estrogen receptor alpha
5) Confidence 0.08 Published 2009 Journal Hum. Reprod. Section Body Doc Link 19661125 Disease Relevance 0.17 Pain Relevance 0

General Comments

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