INT73914

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Context Info
Confidence 0.39
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.75
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Esr1) nucleus (Esr1) enzyme binding (Esr1)
DNA binding (Esr1) protein complex (Esr1) transcription factor binding (Esr1)
Anatomy Link Frequency
pituitary 2
Esr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 4 98.20 Very High Very High Very High
Cholecystokinin 10 97.56 Very High Very High Very High
Neuropeptide 3 95.44 Very High Very High Very High
Central nervous system 2 88.24 High High
Hippocampus 5 88.08 High High
amygdala 2 81.36 Quite High
Glutamate 3 39.88 Quite Low
antagonist 2 27.68 Quite Low
Dopamine 35 5.00 Very Low Very Low Very Low
gABA 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lordosis 2 99.56 Very High Very High Very High
Schizophrenia 220 94.28 High High
Galactorrhea 4 86.76 High High
Urological Neuroanatomy 4 82.00 Quite High
Congenital Anomalies 44 76.64 Quite High
Disease 26 43.76 Quite Low
Toxicity 4 40.24 Quite Low
Stress 14 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Estrogen down-regulates the expression of the estrogen receptor alpha (ER alpha) mRNA in the nuclei of the circuit.
Negative_regulation (down-regulates) of Transcription (expression) of estrogen receptor alpha
1) Confidence 0.39 Published 1998 Journal Endocrinology Section Abstract Doc Link 9492057 Disease Relevance 0.10 Pain Relevance 0.36
Estrogen down-regulates the expression of the estrogen receptor alpha (ER alpha) mRNA in the nuclei of the circuit.
Negative_regulation (down-regulates) of Transcription (expression) of ER alpha
2) Confidence 0.39 Published 1998 Journal Endocrinology Section Abstract Doc Link 9492057 Disease Relevance 0.10 Pain Relevance 0.36
Neonatal and pubertal exposure to BPA alters or disrupts hypothalamic ERalpha transcription in a sexually dimorphic manner.82,85 Neonatal BPA exposure of female animals causes increases of ERalpha but not ERbeta in the medial basal hypothalamus but not in the anterior pituitary.84 In males, BPA increases both ERalplha and ERbeta in the pituitary but not in the hypothalamus.84 BPA treatment causes delayed and sustained hyperprolactinemia in both sexes of offspring,84 which could explain some portion of these changes in ERs.
Negative_regulation (disrupts) of Transcription (transcription) of ERalpha in pituitary associated with galactorrhea
3) Confidence 0.03 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.56 Pain Relevance 0.13

General Comments

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