INT73917

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Context Info
Confidence 0.25
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.50
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Esr1) nucleus (Esr1) enzyme binding (Esr1)
DNA binding (Esr1) protein complex (Esr1) transcription factor binding (Esr1)
Anatomy Link Frequency
pituitary 2
uterine 2
hypothalamus 1
hippocampus 1
Esr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 10 100.00 Very High Very High Very High
Enkephalin 2 98.00 Very High Very High Very High
amygdala 4 97.82 Very High Very High Very High
Cholecystokinin 5 97.36 Very High Very High Very High
Neuropeptide 3 95.24 Very High Very High Very High
Central nervous system 1 88.04 High High
antagonist 12 70.08 Quite High
Glutamate 6 54.16 Quite High
member 8 2 9.76 Low Low
Dopamine 70 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lordosis 1 99.36 Very High Very High Very High
Urological Neuroanatomy 8 98.14 Very High Very High Very High
Schizophrenia 440 94.68 High High
Congenital Anomalies 88 90.92 High High
Galactorrhea 8 86.76 High High
Targeted Disruption 6 79.32 Quite High
Disease 52 58.04 Quite High
Toxicity 8 54.52 Quite High
Endometriosis (extended) 1 54.16 Quite High
Autoimmune Disease 8 8.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Estrogen down-regulates the expression of the estrogen receptor alpha (ER alpha) mRNA in the nuclei of the circuit.
Regulation (regulates) of Transcription (expression) of ER alpha
1) Confidence 0.25 Published 1998 Journal Endocrinology Section Abstract Doc Link 9492057 Disease Relevance 0.10 Pain Relevance 0.36
In addition, estrogen seemed to be a major factor in the regulation of uterine TRPV6 transcription via estrogen receptor ?
Regulation (regulation) of Transcription (transcription) of estrogen receptor in uterine
2) Confidence 0.04 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0.13 Pain Relevance 0.04
Neonatal and pubertal exposure to BPA alters or disrupts hypothalamic ERalpha transcription in a sexually dimorphic manner.82,85 Neonatal BPA exposure of female animals causes increases of ERalpha but not ERbeta in the medial basal hypothalamus but not in the anterior pituitary.84 In males, BPA increases both ERalplha and ERbeta in the pituitary but not in the hypothalamus.84 BPA treatment causes delayed and sustained hyperprolactinemia in both sexes of offspring,84 which could explain some portion of these changes in ERs.
Regulation (alters) of Transcription (transcription) of ERalpha in pituitary associated with galactorrhea
3) Confidence 0.02 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.56 Pain Relevance 0.13
ERs may also play a role in neuropsychiatric disorders as ERalpha mRNA is decreased in the amygdala, frontal cortex, and hippocampus in major psychiatric illnesses.93,131,132 The human forebrain has discrete ERalpha mRNA expression,133 and synapses in the hippocampus depend on estrogen.134,135 Estrogen also regulates the growth-associated protein, GAP-43, in the rat hypothalamus, and GAP-43 is abnormal in schizophrenia.136–138
Regulation (depend) of in hypothalamus Transcription (expression) of ERalpha in hippocampus associated with urological neuroanatomy, hippocampus, amygdala and schizophrenia
4) Confidence 0.02 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.71 Pain Relevance 0.18

General Comments

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