INT73918

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Context Info
Confidence 0.66
First Reported 1998
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 8.74
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Esr1) nucleus (Esr1) enzyme binding (Esr1)
DNA binding (Esr1) protein complex (Esr1) transcription factor binding (Esr1)
Anatomy Link Frequency
hippocampus 3
ovaries 2
TMJ 1
uterine 1
amygdala 1
Esr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 35 100.00 Very High Very High Very High
opioid receptor 2 100.00 Very High Very High Very High
Pain 46 99.38 Very High Very High Very High
nociceptor 5 99.38 Very High Very High Very High
Snapping jaw 6 99.32 Very High Very High Very High
amygdala 14 99.16 Very High Very High Very High
Enkephalin 4 97.44 Very High Very High Very High
Cholecystokinin 10 96.80 Very High Very High Very High
orphanin 1 95.32 Very High Very High Very High
Neuropeptide 10 94.68 High High
Disease Link Frequency Relevance Heat
Schizophrenia 1540 99.84 Very High Very High Very High
Temporomandibular Joint Syndrome 6 99.32 Very High Very High Very High
Lordosis 2 98.80 Very High Very High Very High
Urological Neuroanatomy 28 98.76 Very High Very High Very High
Congenital Anomalies 312 96.92 Very High Very High Very High
Apoptosis 608 93.28 High High
Overactive Bladder 2 91.76 High High
Nociception 1 90.20 High High
Rheumatoid Arthritis 1 89.36 High High
Osteoarthritis 1 88.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Estrogen down-regulates the expression of the estrogen receptor alpha (ER alpha) mRNA in the nuclei of the circuit.
Transcription (expression) of estrogen receptor alpha
1) Confidence 0.66 Published 1998 Journal Endocrinology Section Abstract Doc Link 9492057 Disease Relevance 0.10 Pain Relevance 0.36
Estrogen down-regulates the expression of the estrogen receptor alpha (ER alpha) mRNA in the nuclei of the circuit.
Transcription (expression) of ER alpha
2) Confidence 0.66 Published 1998 Journal Endocrinology Section Abstract Doc Link 9492057 Disease Relevance 0.10 Pain Relevance 0.36
In this study we examined the expression of ER alpha protein and mRNA in the TMJ of adult male rats by immunocytochemistry and in situ hybridization histochemistry.
Spec (examined) Transcription (expression) of ER alpha protein in TMJ associated with snapping jaw
3) Confidence 0.53 Published 2003 Journal The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Section Abstract Doc Link 12973717 Disease Relevance 0.87 Pain Relevance 0.49
Sex-related differences in the distribution of opioid receptor-like 1 receptor mRNA and colocalization with estrogen receptor mRNA in neurons of the spinal trigeminal nucleus caudalis in the rat.
Transcription (distribution) of estrogen receptor in neurons associated with nociceptor and opioid receptor
4) Confidence 0.51 Published 2003 Journal Neuroscience Section Title Doc Link 12710984 Disease Relevance 0.09 Pain Relevance 0.54
We have investigated whether bladder afferent neurons are likely to be targets for circulating estrogens by mapping estrogen receptor (ER) distribution in lumbosacral dorsal root ganglia (DRG) of adult female rats.
Transcription (distribution) of estrogen receptor in afferent neurons
5) Confidence 0.43 Published 2003 Journal Auton Neurosci Section Abstract Doc Link 12798205 Disease Relevance 0.17 Pain Relevance 0.17
To determine whether ERalpha and ERbeta genes are expressed in the rat CL post-partum, we performed semiquantitative RT-PCR to specifically detect the ERalpha and ERbeta mRNA transcripts.
Transcription (transcripts) of ERalpha
6) Confidence 0.37 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236958 Disease Relevance 0.09 Pain Relevance 0
We also demonstrated the expression of ERalpha and ERbeta mRNA transcripts in the two populations of CL found in this species after parturition (i.e. the newly formed CL after post-partum ovulation and the old CL of pregnancy).
Transcription (expression) of ERalpha
7) Confidence 0.37 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236958 Disease Relevance 0.54 Pain Relevance 0
To determine whether ERalpha and ERbeta genes are expressed in the rat CL post-partum, we performed semiquantitative RT-PCR to specifically detect the ERalpha and ERbeta mRNA transcripts.
Transcription (expressed) of ERalpha
8) Confidence 0.36 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236958 Disease Relevance 0.09 Pain Relevance 0
Figure 5A shows that ERalpha and ERbeta mRNA transcripts are highly expressed 4 days after parturition in both types of CL found within the ovaries.
Transcription (expressed) of ERalpha in ovaries
9) Confidence 0.27 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236958 Disease Relevance 0.25 Pain Relevance 0
ERalpha and ERbeta mRNAs were expressed in CL of day 4 post-partum animals at levels similar to those found in CL of day 15 pregnant animals.


Transcription (expressed) of ERalpha
10) Confidence 0.27 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1236958 Disease Relevance 0.38 Pain Relevance 0
Figure 5A shows that ERalpha and ERbeta mRNA transcripts are highly expressed 4 days after parturition in both types of CL found within the ovaries.
Transcription (transcripts) of ERalpha in ovaries
11) Confidence 0.27 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236958 Disease Relevance 0.20 Pain Relevance 0
We also demonstrated the expression of ERalpha and ERbeta mRNA transcripts in the two populations of CL found in this species after parturition (i.e. the newly formed CL after post-partum ovulation and the old CL of pregnancy).
Transcription (transcripts) of ERalpha
12) Confidence 0.27 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236958 Disease Relevance 0.53 Pain Relevance 0
estrogen receptor with a high dissociation rate, it did not demonstrate
Neg (not) Transcription (demonstrate) of estrogen receptor
13) Confidence 0.16 Published 2009 Journal Journal of Toxicology Section Body Doc Link PMC2809433 Disease Relevance 0.05 Pain Relevance 0
In addition, estrogen seemed to be a major factor in the regulation of uterine TRPV6 transcription via estrogen receptor ?
Transcription (transcription) of estrogen receptor in uterine
14) Confidence 0.06 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0.13 Pain Relevance 0.04
Semi-quantitative RT-PCR was performed to assess the expression of estrogen receptor mRNA (ER?
Transcription (expression) of estrogen receptor
15) Confidence 0.05 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 0 Pain Relevance 0
Neonatal and pubertal exposure to BPA alters or disrupts hypothalamic ERalpha transcription in a sexually dimorphic manner.82,85 Neonatal BPA exposure of female animals causes increases of ERalpha but not ERbeta in the medial basal hypothalamus but not in the anterior pituitary.84 In males, BPA increases both ERalplha and ERbeta in the pituitary but not in the hypothalamus.84 BPA treatment causes delayed and sustained hyperprolactinemia in both sexes of offspring,84 which could explain some portion of these changes in ERs.
Transcription (transcription) of ERalpha in pituitary associated with galactorrhea
16) Confidence 0.05 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.55 Pain Relevance 0.12
ERs may also play a role in neuropsychiatric disorders as ERalpha mRNA is decreased in the amygdala, frontal cortex, and hippocampus in major psychiatric illnesses.93,131,132 The human forebrain has discrete ERalpha mRNA expression,133 and synapses in the hippocampus depend on estrogen.134,135 Estrogen also regulates the growth-associated protein, GAP-43, in the rat hypothalamus, and GAP-43 is abnormal in schizophrenia.136–138
Transcription (expression) of ERalpha in hippocampus associated with urological neuroanatomy, hippocampus, amygdala and schizophrenia
17) Confidence 0.05 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.71 Pain Relevance 0.17
ERs may also play a role in neuropsychiatric disorders as ERalpha mRNA is decreased in the amygdala, frontal cortex, and hippocampus in major psychiatric illnesses.93,131,132 The human forebrain has discrete ERalpha mRNA expression,133 and synapses in the hippocampus depend on estrogen.134,135 Estrogen also regulates the growth-associated protein, GAP-43, in the rat hypothalamus, and GAP-43 is abnormal in schizophrenia.136–138
Transcription (discrete) of ERalpha in hippocampus associated with urological neuroanatomy, hippocampus, amygdala and schizophrenia
18) Confidence 0.05 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.71 Pain Relevance 0.17
ERs may also play a role in neuropsychiatric disorders as ERalpha mRNA is decreased in the amygdala, frontal cortex, and hippocampus in major psychiatric illnesses.93,131,132 The human forebrain has discrete ERalpha mRNA expression,133 and synapses in the hippocampus depend on estrogen.134,135 Estrogen also regulates the growth-associated protein, GAP-43, in the rat hypothalamus, and GAP-43 is abnormal in schizophrenia.136–138
Transcription (abnormal) of ERalpha in synapses associated with urological neuroanatomy, hippocampus, amygdala and schizophrenia
19) Confidence 0.05 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.78 Pain Relevance 0.18
ERs may also play a role in neuropsychiatric disorders as ERalpha mRNA is decreased in the amygdala, frontal cortex, and hippocampus in major psychiatric illnesses.93,131,132 The human forebrain has discrete ERalpha mRNA expression,133 and synapses in the hippocampus depend on estrogen.134,135 Estrogen also regulates the growth-associated protein, GAP-43, in the rat hypothalamus, and GAP-43 is abnormal in schizophrenia.136–138
Transcription (mRNA) of ERalpha in amygdala associated with urological neuroanatomy, hippocampus, amygdala and schizophrenia
20) Confidence 0.05 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.80 Pain Relevance 0.17

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