INT73926

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.14
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
oxidoreductase activity (ALOX5) nucleus (ALOX5) cytoplasm (ALOX5)
Anatomy Link Frequency
chondrocytes 1
FIB 1
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 24 100.00 Very High Very High Very High
Osteoarthritis 149 98.60 Very High Very High Very High
cytokine 4 95.96 Very High Very High Very High
cINOD 11 94.60 High High
COX-2 inhibitor 5 59.76 Quite High
Angina 6 54.76 Quite High
corticosteroid 1 33.52 Quite Low
alcohol 3 27.84 Quite Low
Inflammation 22 19.84 Low Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 133 100.00 Very High Very High Very High
Acute Coronary Syndrome 84 100.00 Very High Very High Very High
Stroke 3 100.00 Very High Very High Very High
Osteoarthritis 154 98.60 Very High Very High Very High
Injury 3 96.84 Very High Very High Very High
INFLAMMATION 31 94.36 High High
Myocardial Infarction 24 91.04 High High
Heart Disease 6 90.48 High High
Ulcers 2 75.00 Quite High
Cv General 3 Under Development 6 54.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A hydrophilic polymer, hydroxypropyl cellulose (HPC), provides the non-Fickian slower release of the lipophilic drug, lidocaine (logP=2.6) and the burst (Fickian) release of hydrophilic drug, lidocaine hydrochloride (logP<or=0).
Localization (release) of logP associated with lidocaine
1) Confidence 0.44 Published 2010 Journal Int J Pharm Section Abstract Doc Link 20540996 Disease Relevance 0 Pain Relevance 0.47
A hydrophilic polymer, hydroxypropyl cellulose (HPC), provides the non-Fickian slower release of the lipophilic drug, lidocaine (logP=2.6) and the burst (Fickian) release of hydrophilic drug, lidocaine hydrochloride (logP<or=0).
Localization (release) of logP associated with lidocaine
2) Confidence 0.39 Published 2010 Journal Int J Pharm Section Abstract Doc Link 20540996 Disease Relevance 0 Pain Relevance 0.61
As seen in Table 2, the interaction term included in the LoS model show that, for patients with ICP, the LoS is lower for patients near a cardiology center than for those farther, whereas, for patients not receiving ICP, those that are closer have not a lower LoS than the others.
Localization (lower) of LoS
3) Confidence 0.24 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.19 Pain Relevance 0
If the care for ACS was delivered over several contiguous hospitalizations involving hospital transfer, the presence of an ICP, HD and the LoS were evaluated for the entire episode.
Localization (presence) of LoS associated with acute coronary syndrome and death
4) Confidence 0.24 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.67 Pain Relevance 0
Although the geographical localization of specialized centers for stroke treatment in Canada [11] has been described in terms of theoretical accessibility to specialized care for a specific population, a more comprehensive ACS model taking into account ICP, HD, LoS, EHR as well as demographic and geographic variables remains to be described.
Localization (localization) of LoS associated with acute coronary syndrome, stroke and death
5) Confidence 0.24 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 1.54 Pain Relevance 0.05
1 production could be involved in HNE-induced 5-LOX and FLAP expression, chondrocytes were treated or not with a single addition of 10 ?
Neg (not) Localization (treated) of 5-LOX in chondrocytes
6) Confidence 0.24 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.05 Pain Relevance 0.03
We also examined the implication of both 5-LO and FLAP in the production of LTB4 in these cells and the factors that might modulate their expression.
Localization (implication) of 5-LO
7) Confidence 0.09 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.35 Pain Relevance 0.21
The effects of lipoxygenase metabolites on collagen secretion was small, but different in both types of FIB.
Localization (secretion) of lipoxygenase in FIB
8) Confidence 0.06 Published 1998 Journal Eur Surg Res Section Abstract Doc Link 9493694 Disease Relevance 0.34 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox