INT73927

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Context Info
Confidence 0.48
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 3.55
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (FBL) nucleolus (FBL) RNA binding (FBL)
nucleus (FBL)
Anatomy Link Frequency
Tendon cells 2
blood 1
skin 1
FIB 1
mesenchymal cells 1
FBL (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 324 99.26 Very High Very High Very High
cINOD 2 94.00 High High
cytokine 2 89.84 High High
Arthritis 42 89.60 High High
dexamethasone 260 89.56 High High
Osteoarthritis 18 88.76 High High
cva 1 34.60 Quite Low
corticosteroid 16 15.80 Low Low
Leflunomide 12 12.28 Low Low
methotrexate 12 9.28 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 324 99.26 Very High Very High Very High
Adhesions 1 96.68 Very High Very High Very High
Ulcers 4 94.12 High High
INFLAMMATION 8 92.56 High High
Injury 19 90.72 High High
Polymyositis 12 90.28 High High
Seronegative Spondarthritis 18 89.60 High High
Osteoarthritis 18 88.76 High High
Sprains And Strains 16 77.68 Quite High
Polymyalgia Rheumatica 12 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that, when compared to skin FIB, human gastric FIB produce less collagen and show pronounced different responses to different agents, which might be relevant to explain (in part) their clinical effects on ulcer healing.
Gene_expression (produce) of FIB in FIB associated with ulcers
1) Confidence 0.48 Published 1998 Journal Eur Surg Res Section Abstract Doc Link 9493694 Disease Relevance 0.41 Pain Relevance 0.13
Serum and epidermal growth factor increased collagen secretion in both types of FIB, but gastric FIB produced less collagen than skin FIB.
Gene_expression (produced) of FIB in skin
2) Confidence 0.48 Published 1998 Journal Eur Surg Res Section Abstract Doc Link 9493694 Disease Relevance 0.33 Pain Relevance 0.14
In the present study, we describe the diagnostic performance of an assay, based on the detection of AhFibA.
Gene_expression (detection) of AhFibA
3) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779401 Disease Relevance 0.23 Pain Relevance 0.11
Detection of AhFibA antibodies by ELISA
Gene_expression (Detection) of AhFibA
4) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779401 Disease Relevance 0.06 Pain Relevance 0.03
Indeed, at the 98.5% specificity level only 11 non-RA patients exhibited any ACPA reactivity, of which only three were positive for both AhFibA and anti-CCP2 antibodies (Table 2).
Gene_expression (antibodies) of AhFibA associated with rheumatoid arthritis
5) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779401 Disease Relevance 0.26 Pain Relevance 0.10
Detection of AhFibA antibodies by ELISA
Gene_expression (antibodies) of AhFibA
6) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779401 Disease Relevance 0.06 Pain Relevance 0.03
In this cohort of longstanding RA patients, the agreement between the AhFibA assay and the anti-CCP2 assay corresponded with the agreement observed in the RA patients of population 1.
Gene_expression (assay) of AhFibA associated with rheumatoid arthritis
7) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779401 Disease Relevance 1.06 Pain Relevance 0.49
Agreement between the AhFibA assay and anti-CCP2 in population 1
Gene_expression (assay) of AhFibA
8) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779401 Disease Relevance 0.79 Pain Relevance 0.29
Hemorheologically important data describing the blood composition, such as COP and TP (for blood viscosity), ALB/TP ratio (for blood cell aggregability), Fib values (blood cell aggregability, coagulation, and viscosity), WBC (fluid dynamics, cell adhesion, and clot formation), and Hct (cell aggregability and viscosity), did not significantly differ between the two main study groups (therefore, data are not shown).
Gene_expression (values) of Fib in blood associated with adhesions
9) Confidence 0.04 Published 2007 Journal Crit Care Section Body Doc Link PMC2151875 Disease Relevance 0.16 Pain Relevance 0
Tendon cells have been shown to express the human fibroblastic markers D7-FIB [11,12] and CD90 as well as other markers expressed by MSCs (eg.
Gene_expression (expressed) of D7-FIB in Tendon cells
10) Confidence 0.02 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0 Pain Relevance 0.15
Tendon cells have been shown to express the human fibroblastic markers D7-FIB [11,12] and CD90 as well as other markers expressed by MSCs (eg.
Gene_expression (express) of D7-FIB in Tendon cells
11) Confidence 0.02 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0 Pain Relevance 0.15
Although the literature is limited, tendon cells have been shown to express a number of markers including the human fibroblastic markers D7-FIB [11,12] and CD90 (data not shown) as well as other markers characteristic of mesenchymal cells (CD13 & CD44) (data not shown).
Gene_expression (express) of D7-FIB in mesenchymal cells
12) Confidence 0.02 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0.13 Pain Relevance 0
Here we found that in a group of four PT/ACL pairs the intensity of expression of CD90 was consistently lower in the ACL as compared to the patellar and the expression of D7 FIB was consistently higher, whereas the pattern of response was inconsistent in the other markers.
Gene_expression (expression) of D7 FIB
13) Confidence 0.02 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0.06 Pain Relevance 0.10

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