INT73938

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Context Info
Confidence 0.76
First Reported 1997
Last Reported 2009
Negated 3
Speculated 1
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 12.27
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Cd36) transport (Cd36) mitochondrion (Cd36)
cell adhesion (Cd36) Golgi apparatus (Cd36) plasma membrane (Cd36)
Anatomy Link Frequency
platelets 2
reticulocytes 2
monocytes 1
Muscle 1
red blood cells 1
Cd36 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 14 98.46 Very High Very High Very High
Pain 5 89.08 High High
chemokine 7 52.24 Quite High
corticosteroid 96 51.68 Quite High
abdominal pain 2 9.36 Low Low
Inflammation 34 5.00 Very Low Very Low Very Low
dexamethasone 20 5.00 Very Low Very Low Very Low
cytokine 18 5.00 Very Low Very Low Very Low
fibrosis 16 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 118 99.60 Very High Very High Very High
Hypertension 98 99.16 Very High Very High Very High
Heart Disease 18 99.12 Very High Very High Very High
Diabetes Mellitus 76 98.68 Very High Very High Very High
Targeted Disruption 12 98.64 Very High Very High Very High
Cv General 3 Under Development 13 98.46 Very High Very High Very High
Myocardial Infarction 12 98.24 Very High Very High Very High
Dilated Cardiomyopathy 12 98.00 Very High Very High Very High
Hypertrophic Cardiomyopathy 12 97.80 Very High Very High Very High
Sickle Cell Anemia 15 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sixteen patients (3 with HCM, 1 with DCM, 1 with OMI, 8 with AP, and 3 with other heart diseases) showed type II CD36 deficiency (monocytes expressed CD36 but platelets did not).
Gene_expression (expressed) of CD36 in platelets associated with angina, hypertrophic cardiomyopathy, heart disease, dilated cardiomyopathy and myocardial infarction
1) Confidence 0.76 Published 1997 Journal Kaku Igaku Section Abstract Doc Link 9494334 Disease Relevance 1.77 Pain Relevance 0.35
In this study, we analyzed CD36 expression in 200 patients with heart diseases [44 patients with hypertrophic cardiomyopathy (HCM), 16 with dilated cardiomyopathy (DCM), 26 with old myocardial infarction (OMI), 55 with angina pectoris (AP) and 59 with other miscellaneous heart diseases] using a flow cytometer. 123I-beta-methyl-p-iodophenylpentadecanoic acid (BMIPP) myocardial accumulation was also examined in some patients.
Spec (analyzed) Gene_expression (expression) of CD36 in heart associated with angina, hypertrophic cardiomyopathy, heart disease, dilated cardiomyopathy and myocardial infarction
2) Confidence 0.76 Published 1997 Journal Kaku Igaku Section Abstract Doc Link 9494334 Disease Relevance 1.52 Pain Relevance 0.30
Eight patients (2 with HCM, 1 with DCM, 2 with OMI, and 3 with AP) were diagnosed as having type I CD36 deficiency (neither platelets nor monocytes expressed CD36).
Neg (neither) Gene_expression (expressed) of CD36 in monocytes associated with angina, hypertrophic cardiomyopathy, dilated cardiomyopathy and myocardial infarction
3) Confidence 0.76 Published 1997 Journal Kaku Igaku Section Abstract Doc Link 9494334 Disease Relevance 1.85 Pain Relevance 0.37
No CD36 expression in either platelets or monocytes/macrophages was shown using flow cytometer analysis and type I CD36 deficiency was diagnosed.
Gene_expression (expression) of CD36 in platelets
4) Confidence 0.75 Published 2005 Journal Heart Vessels Section Abstract Doc Link 15912310 Disease Relevance 0.68 Pain Relevance 0.07
Flow cytometry showed that CD36 was absent from the circulating red blood cells and reticulocytes of platelet CD36--deficient individuals but present on those from patients with normal platelet CD36 expression, and that alpha(4)beta(1) integrin levels were similar on the reticulocytes of the 2 groups.
Gene_expression (expression) of CD36 in reticulocytes
5) Confidence 0.71 Published 2001 Journal Blood Section Abstract Doc Link 11493440 Disease Relevance 0.41 Pain Relevance 0.06
The nonexpression of CD36 on reticulocytes and mature red blood cells does not modify the clinical course of patients with sickle cell anemia.
Gene_expression (nonexpression) of CD36 in red blood cells associated with sickle cell anemia
6) Confidence 0.71 Published 2001 Journal Blood Section Title Doc Link 11493440 Disease Relevance 0.52 Pain Relevance 0.09
activated gene expression of fatty acid transport proteins, peroxisomal and mitochondrial fatty acid ?
Gene_expression (expression) of fatty acid transport
7) Confidence 0.65 Published 2009 Journal PPAR Research Section Abstract Doc Link PMC2840373 Disease Relevance 0.78 Pain Relevance 0
The prolonged returning of FAT expression and the second trough of GPAT at 48 h raises the possibility that at least one intermediate biosignal is involved.
Gene_expression (expression) of FAT
8) Confidence 0.63 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0.12 Pain Relevance 0
Simultaneous modeling using the proposed model well captured the expression of FAT and GPAT (Fig. 10).
Gene_expression (expression) of FAT
9) Confidence 0.63 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0.08 Pain Relevance 0
Flow cytometry showed that CD36 was absent from the circulating red blood cells and reticulocytes of platelet CD36--deficient individuals but present on those from patients with normal platelet CD36 expression, and that alpha(4)beta(1) integrin levels were similar on the reticulocytes of the 2 groups.
Neg (absent) Gene_expression (present) of CD36 in reticulocytes
10) Confidence 0.62 Published 2001 Journal Blood Section Abstract Doc Link 11493440 Disease Relevance 0.45 Pain Relevance 0.07
The FAT and GPAT mRNA (mRNA) versus time profiles were described as:
Gene_expression (profiles) of FAT
11) Confidence 0.55 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
Muscle-specific over expression of FAT reverses insulin resistance and diabetes in animal models (Heron-Milhavet et al. 2004).
Gene_expression (expression) of FAT in Muscle associated with diabetes mellitus and insulin resistance
12) Confidence 0.49 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0.20 Pain Relevance 0.03
Well-known candidate genes with reduced expression in SHR include fatty acid translocase (Cd36) and glutathione-S-transferase (Gstm1).
Gene_expression (include) of fatty acid translocase
13) Confidence 0.45 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0.42 Pain Relevance 0
Our amplification plot of qPCR clearly confirms the existence of different gene products of Cd36 in WKY and SHR.
Gene_expression (products) of Cd36
14) Confidence 0.45 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0.78 Pain Relevance 0
Well-known candidate genes with reduced expression in SHR include fatty acid translocase (Cd36) and glutathione-S-transferase (Gstm1).
Gene_expression (include) of Cd36
15) Confidence 0.45 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0.42 Pain Relevance 0
Moreover, the Cd36 mutation was absent in the original SHR [15, 35].
Neg (absent) Gene_expression (absent) of Cd36
16) Confidence 0.40 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0.89 Pain Relevance 0
Due to deletion in Cd36 caused by unequal recombination [14], gene expression of Cd36 cannot be directly compared in WKY vs.
Gene_expression (expression) of Cd36
17) Confidence 0.40 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2691531 Disease Relevance 0 Pain Relevance 0
Flow cytometric immunophenotyping demonstrated expression of HLA-DR+/CD64+, CD36+/CD116+, CD14+/-, cCD68+, CD33++, CD13+/-, CD4+ and non expression of CD34, CD79a, CD20, CD10 and, CD3.
Gene_expression (expression) of CD36
18) Confidence 0.23 Published 2006 Journal J Occup Med Toxicol Section Body Doc Link PMC1544343 Disease Relevance 0.61 Pain Relevance 0
THP1 cells showed that C-peptide increases the expression of CD36, an important
Gene_expression (expression) of CD36
19) Confidence 0.19 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.48 Pain Relevance 0.03
CHO-745 cells expressing the endothelial receptors CD36, ICAM-1, VCAM-1 and P-selectin, and CHO-745 control cells expressing GFP were plated onto 15-mm coverslips and maintained in 24-well plates.
Gene_expression (expressing) of CD36
20) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2758591 Disease Relevance 0.07 Pain Relevance 0

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