INT7394

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Context Info
Confidence 0.69
First Reported 1983
Last Reported 2010
Negated 1
Speculated 6
Reported most in Abstract
Documents 67
Total Number 76
Disease Relevance 7.22
Pain Relevance 25.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1)
cell-cell signaling (GNRH1)
Anatomy Link Frequency
gonadal 15
neurons 14
arcuate nucleus 10
pituitary 9
plasma 3
GNRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 95 100.00 Very High Very High Very High
Opioid 39 100.00 Very High Very High Very High
Endogenous opioid 33 100.00 Very High Very High Very High
Dopamine 94 99.92 Very High Very High Very High
Catecholamine 22 99.92 Very High Very High Very High
Clonidine 17 99.92 Very High Very High Very High
agonist 77 99.86 Very High Very High Very High
antagonist 68 99.84 Very High Very High Very High
Locus ceruleus 3 99.64 Very High Very High Very High
gABA 23 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Reprotox - General 1 58 99.92 Very High Very High Very High
Fibromyalgia 16 96.02 Very High Very High Very High
Acromegaly 166 95.32 Very High Very High Very High
Reprotox - General 3 41 94.28 High High
Precocious Puberty 23 92.80 High High
Male Infertility 18 90.48 High High
Adrenal Cancer 139 88.92 High High
Bordatella Infection 2 85.52 High High
Syndrome 12 81.28 Quite High
Polycystic Ovary Syndrome 18 78.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, both morphine and UP50, 488H significantly inhibited 8-bromo-cAMP-induced GnRH release.
Positive_regulation (induced) of Localization (release) of GnRH associated with morphine
1) Confidence 0.69 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2156890 Disease Relevance 0 Pain Relevance 0.68
Pulse injection of an opiate receptor antagonist, naloxone, reproducibly elicited an acute increase in GnRH release within 30 min.
Positive_regulation (increase) of Localization (release) of GnRH associated with antagonist, narcan and opiate
2) Confidence 0.69 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6311863 Disease Relevance 0 Pain Relevance 0.53
Opioid agonists at their concentrations causing maximal release of hCG from the tissue also stimulated GnRH secretion.
Positive_regulation (stimulated) of Localization (secretion) of GnRH associated with mu agonist
3) Confidence 0.69 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8114013 Disease Relevance 0 Pain Relevance 0.76
The A-type potassium-channel antagonist 4-aminopyridine (1 mM) increased both firing rate and GnRH secretion, demonstrating the presence of A-type currents in these cells and supporting the hypothesis that electrical activity is associated with GnRH release.
Positive_regulation (increased) of Localization (secretion) of GnRH associated with antagonist
4) Confidence 0.68 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11431490 Disease Relevance 0 Pain Relevance 0.18
All four peptides stimulated LHRH release from GT1-7 cells with a rank-ordered potency of NPY = peptide YY > Y1 agonist = Y2 agonist.
Positive_regulation (stimulated) of Localization (release) of LHRH associated with agonist and potency
5) Confidence 0.67 Published 1994 Journal Endocrinology Section Abstract Doc Link 7925125 Disease Relevance 0.15 Pain Relevance 0.40
The effects of some adrenergic receptor agonists (1 microM) on GnRH release from P-AH slices were tested: phenylephrine (alpha 1-agonist) significantly stimulated GnRH release; clonidine (alpha 2-agonist) and isoproterenol (beta-agonist) were ineffective.
Positive_regulation (stimulated) of Localization (release) of GnRH associated with agonist and clonidine
6) Confidence 0.65 Published 1992 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 1348716 Disease Relevance 0 Pain Relevance 0.55
Incubation of P-AH slices with phentolamine (alpha 1/alpha 2-antagonist) and prazosin (alpha 1-antagonist), at a concentration of 1 microM, inhibited the release of GnRH induced by NE (60 microM); the alpha 2-antagonist yombibin and the beta-antagonist propanolol were ineffective.
Positive_regulation (induced) of Localization (release) of GnRH associated with antagonist
7) Confidence 0.65 Published 1992 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 1348716 Disease Relevance 0 Pain Relevance 0.74
When the PGE2 production was blocked by indomethacin in the ARN plus ME preparation, DTLET increased the release of GnRH and induced the production of leukotrienes (LTs).
Positive_regulation (increased) of Localization (release) of GnRH in ARN
8) Confidence 0.65 Published 1993 Journal Brain Res. Section Abstract Doc Link 8281433 Disease Relevance 0 Pain Relevance 0.37
In the isolated ME, DTLET reduced the secretion of PGE2 but enhanced the release of GnRH.
Positive_regulation (enhanced) of Localization (release) of GnRH
9) Confidence 0.65 Published 1993 Journal Brain Res. Section Abstract Doc Link 8281433 Disease Relevance 0 Pain Relevance 0.37
In static incubations, the K+ induced release of gonadotropin-releasing hormone (GnRH) and of prostaglandin (PG) E2, was 2-3 times higher in the isolated median eminence (ME) compared to the hypothalamic area containing the arcuate nucleus (ARN) plus the ME.
Positive_regulation (induced) of Localization (release) of GnRH in arcuate nucleus
10) Confidence 0.65 Published 1993 Journal Brain Res. Section Abstract Doc Link 8281433 Disease Relevance 0 Pain Relevance 0.27
Previous results have shown that both dopamine (DA) and norepinephrine (NE) stimulate GnRH secretion in GT1 neuronal cell lines.
Positive_regulation (stimulate) of Localization (secretion) of GnRH in neuronal associated with dopamine
11) Confidence 0.61 Published 1996 Journal Life Sci. Section Abstract Doc Link 8622571 Disease Relevance 0 Pain Relevance 0.23
Inositol phosphates production was stimulated by DA and NE only at a concentration of 100 microM, i.e. two to three orders of magnitude higher than the effective concentrations to maximally stimulate GnRH secretion.
Positive_regulation (stimulate) of Localization (secretion) of GnRH associated with dopamine
12) Confidence 0.61 Published 1996 Journal Life Sci. Section Abstract Doc Link 8622571 Disease Relevance 0 Pain Relevance 0.54
Since the signaling pathway triggered by phosphoinositide hydrolysis is a potent stimulator of GnRH secretion and appears to mediate the releasing actions of neuromediators such as histamine and endothelin, we investigated if this signaling pathway was also involved in the catecholaminergic stimulation of GnRH release in GT1 cells.
Positive_regulation (stimulation) of Localization (release) of GnRH
13) Confidence 0.61 Published 1996 Journal Life Sci. Section Abstract Doc Link 8622571 Disease Relevance 0 Pain Relevance 0.37
However, in spite of a similar efficacy of these catecholamines to stimulate GnRH secretion, DA is two-fold more efficacious than NE to stimulate the formation of cyclic AMP.
Positive_regulation (stimulate) of Localization (secretion) of GnRH associated with dopamine and catecholamine
14) Confidence 0.61 Published 1996 Journal Life Sci. Section Abstract Doc Link 8622571 Disease Relevance 0 Pain Relevance 0.26
Although it has been assumed that synchronized firing of gonadotropin-releasing hormone (GnRH) neurons is necessary for pulsatile GnRH secretion, there is no clear evidence for this.
Positive_regulation (necessary) of Localization (secretion) of GnRH in neurons
15) Confidence 0.57 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11307034 Disease Relevance 0 Pain Relevance 0.19
An increased inhibitory action of EOP on GnRH release may explain the inefficacy of naloxone to stimulate LH secretion in hypogonadotropinic patients, while a decreased action has been hypothesized in postmenopausal women.
Positive_regulation (increased) of Localization (release) of GnRH associated with narcan
16) Confidence 0.53 Published 1989 Journal J. Steroid Biochem. Section Abstract Doc Link 2689783 Disease Relevance 0.16 Pain Relevance 0.56
Human fertility is ultimately dependent upon the regular pulsatile release of gonadotrophin releasing hormone (GnRH) from hypothalamic neurons.
Positive_regulation (dependent) of Localization (release) of GnRH in neurons
17) Confidence 0.50 Published 1993 Journal Hum. Reprod. Section Abstract Doc Link 8276951 Disease Relevance 0 Pain Relevance 0.24
Human fertility is ultimately dependent upon the regular pulsatile release of gonadotrophin releasing hormone (GnRH) from hypothalamic neurons.
Positive_regulation (dependent) of Localization (release) of gonadotrophin releasing hormone in neurons
18) Confidence 0.50 Published 1993 Journal Hum. Reprod. Section Abstract Doc Link 8276951 Disease Relevance 0 Pain Relevance 0.24
It is well known that endogenous opioid peptides exert a tonic inhibitory control on GnRH release, leading to the inhibition of LH secretion, whereas eicosanoids, particularly prostaglandin E2(PGE2), stimulate GnRH output.
Positive_regulation (stimulate) of Localization (release) of GnRH associated with endogenous opioid
19) Confidence 0.49 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8626832 Disease Relevance 0 Pain Relevance 0.44
At puberty the pulsatile GnRH secretion, and the subsequent episodic pituitary gonadotropin secretion, which is necessary for normal gonadal development and function, is triggered by the activation of the GnRH pulse generator.
Positive_regulation (necessary) of in gonadal Localization (secretion) of GnRH in pituitary
20) Confidence 0.49 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2958977 Disease Relevance 0 Pain Relevance 0.08

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