INT7395

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Context Info
Confidence 0.81
First Reported 1974
Last Reported 2010
Negated 1
Speculated 11
Reported most in Abstract
Documents 399
Total Number 411
Disease Relevance 62.88
Pain Relevance 117.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1)
cell-cell signaling (GNRH1)
Anatomy Link Frequency
pituitary 35
hypothalamus 30
neurons 29
arcuate nucleus 14
follicle 12
GNRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 652 100.00 Very High Very High Very High
antagonist 499 100.00 Very High Very High Very High
Enkephalin 70 100.00 Very High Very High Very High
Clonidine 55 100.00 Very High Very High Very High
Somatostatin 49 100.00 Very High Very High Very High
Dopamine 308 99.98 Very High Very High Very High
narcan 590 99.92 Very High Very High Very High
Opioid 327 99.92 Very High Very High Very High
addiction 41 99.92 Very High Very High Very High
Endogenous opioid 174 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 14 100.00 Very High Very High Very High
Immunotherapy Of Cancer 11 100.00 Very High Very High Very High
Reprotox - General 1 442 99.92 Very High Very High Very High
Adrenal Cancer 237 99.90 Very High Very High Very High
Trypanosomiasis 3 99.82 Very High Very High Very High
Ovarian Cancer 16 99.76 Very High Very High Very High
Stress 453 99.68 Very High Very High Very High
Anovulation 46 99.56 Very High Very High Very High
Galactorrhea 165 99.44 Very High Very High Very High
Reprotox - General 2 99 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are great species differences in the localization of the GnRH nerve cells.
Localization (localization) of GnRH in nerve cells
1) Confidence 0.81 Published 1989 Journal J. Steroid Biochem. Section Abstract Doc Link 2513450 Disease Relevance 0 Pain Relevance 0.09
Direct connections of the GnRH neurons demonstrated so far does not exclude the possibility that these neurotransmitters or neuromodulators influence GnRH release also at other levels of the CNS.
Localization (release) of GnRH in neurons associated with neurotransmitter
2) Confidence 0.81 Published 1989 Journal J. Steroid Biochem. Section Abstract Doc Link 2513450 Disease Relevance 0 Pain Relevance 0.18
It is likely that neurotransmitters (dopamine, serotonine) and opiates have an inhibitory effect on Gn-RH release.
Localization (release) of Gn-RH associated with dopamine, neurotransmitter and opiate
3) Confidence 0.81 Published 1985 Journal Acta Neurochir (Wien) Section Abstract Doc Link 3993451 Disease Relevance 0.12 Pain Relevance 0.20
These results indicate that the human hypothalamic GnRH pulse-generating mechanism is located entirely within the MBH, and that this pulse generator can maintain intrinsically pulsatile GnRH release independent of all innervation from outside this site.
Localization (release) of GnRH in MBH
4) Confidence 0.80 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2657474 Disease Relevance 0 Pain Relevance 0.43
Our data also demonstrate that human hypothalamic pulsatile GnRH release can be suppressed by an opiate receptor-mediated mechanism located within the MBH.
Localization (release) of GnRH in MBH associated with opiate
5) Confidence 0.80 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2657474 Disease Relevance 0 Pain Relevance 0.43
Pulsatile gonadotropin-releasing hormone release from the human mediobasal hypothalamus in vitro: opiate receptor-mediated suppression.
Localization (release) of gonadotropin-releasing hormone in hypothalamus associated with opiate
6) Confidence 0.80 Published 1989 Journal Neuroendocrinology Section Title Doc Link 2657474 Disease Relevance 0 Pain Relevance 0.38
An in vitro perifusion system was used to investigate pulsatile gonadotropin-releasing hormone (GnRH) release from the fetal (20-23 weeks of gestation) and adult human mediobasal hypothalamus (MBH).
Spec (investigate) Localization (release) of GnRH in MBH
7) Confidence 0.80 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2657474 Disease Relevance 0 Pain Relevance 0.27
The calcium-dependent pulsatile GnRH release from fetal human MBHs was suppressed by addition of morphine (10 microM) to the perifusion medium, and this suppression was reversed by addition of the opiate receptor antagonist naloxone (10 microM).
Localization (release) of GnRH associated with antagonist, narcan, opiate and morphine
8) Confidence 0.80 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2657474 Disease Relevance 0 Pain Relevance 0.42
Adult human MBHs also released GnRH in a pulsatile manner, with a periodicity of 60-100 min.
Localization (released) of GnRH
9) Confidence 0.80 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2657474 Disease Relevance 0 Pain Relevance 0.32
An in vitro perifusion system was used to investigate pulsatile gonadotropin-releasing hormone (GnRH) release from the fetal (20-23 weeks of gestation) and adult human mediobasal hypothalamus (MBH).
Spec (investigate) Localization (release) of gonadotropin-releasing hormone in MBH
10) Confidence 0.80 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2657474 Disease Relevance 0 Pain Relevance 0.27
The present results showed that steroid hormones and opiate receptor agonists influence irGnRH release from human cultured cells, suggesting that local interaction between steroids and peptides modulates irGnRH release from human placenta.
Localization (release) of irGnRH in placenta associated with agonist and opiate
11) Confidence 0.80 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2156890 Disease Relevance 0 Pain Relevance 0.56
However, both morphine and UP50, 488H significantly inhibited 8-bromo-cAMP-induced GnRH release.
Localization (release) of GnRH associated with morphine
12) Confidence 0.80 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2156890 Disease Relevance 0 Pain Relevance 0.68
The aim of the present study was to evaluate whether steroid hormones or opiate receptor agonists participate in the mechanisms regulating the release of immunoreactive GnRH (irGnRH) from cultured human placental cells.
Localization (release) of GnRH associated with agonist and opiate
13) Confidence 0.80 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2156890 Disease Relevance 0 Pain Relevance 0.15
Endogenous opioid regulation of GnRH release from the human fetal (21-23 weeks gestation) mediobasal hypothalamus was investigated in an in vitro perifusion system.
Localization (release) of GnRH in hypothalamus associated with endogenous opioid
14) Confidence 0.80 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6311863 Disease Relevance 0 Pain Relevance 0.48
These studies unequivocally demonstrate that endogenous opiates exert an inhibitory effect on GnRH release from the human fetal mediobasal hypothalamus in vitro.
Localization (release) of GnRH in hypothalamus associated with opiate
15) Confidence 0.80 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6311863 Disease Relevance 0 Pain Relevance 0.51
Pulse injection of an opiate receptor antagonist, naloxone, reproducibly elicited an acute increase in GnRH release within 30 min.
Localization (release) of GnRH associated with antagonist, narcan and opiate
16) Confidence 0.80 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6311863 Disease Relevance 0 Pain Relevance 0.53
The mechanisms involved in inhibiting GnRH release remain unclear in humans.
Localization (release) of GnRH
17) Confidence 0.80 Published 1991 Journal Recent Prog. Horm. Res. Section Abstract Doc Link 1745819 Disease Relevance 0 Pain Relevance 0.15
The data reviewed present evidence that the pattern of GnRH secretion is an important factor in the regulation of gonadotropin subunit gene expression, gonadotropin synthesis, and secretion.
Localization (secretion) of GnRH
18) Confidence 0.80 Published 1991 Journal Recent Prog. Horm. Res. Section Abstract Doc Link 1745819 Disease Relevance 0 Pain Relevance 0
In males, the increased frequency and amplitude of GnRH secretion favor LH synthesis and release, which in turn stimulates testosterone secretion (Fig. 14).
Localization (secretion) of GnRH
19) Confidence 0.80 Published 1991 Journal Recent Prog. Horm. Res. Section Abstract Doc Link 1745819 Disease Relevance 0 Pain Relevance 0.19
During the first year, GnRH secretion is inhibited and both the amplitude and apparent frequency of pulsatile release is markedly reduced.
Localization (secretion) of GnRH
20) Confidence 0.80 Published 1991 Journal Recent Prog. Horm. Res. Section Abstract Doc Link 1745819 Disease Relevance 0 Pain Relevance 0.12

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