INT73950

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm3) plasma membrane (Chrm3) signal transducer activity (Chrm3)
Chrm3 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 7 100.00 Very High Very High Very High
antinociception 3 99.44 Very High Very High Very High
Opioid 1 99.32 Very High Very High Very High
narcan 1 98.60 Very High Very High Very High
agonist 1 94.44 High High
tail-flick 1 93.72 High High
Antinociceptive 4 83.28 Quite High
Disease Link Frequency Relevance Heat
Amnesia 1 46.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antinociception produced by (+/-)-PG-9 was prevented by the unselective muscarinic antagonist atropine, the M1-selective antagonists pirenzepine and dicyclomine and the acetylcholine depletor hemicholinium-3, but not by the opioid antagonist naloxone, the gamma-aminobutyric acidB antagonist 3-aminopropyl-diethoxy-methyl-phosphinic acid, the H3 agonist R-(alpha)-methylhistamine, the D2 antagonist quinpirole, the 5-hydroxytryptamine4 antagonist 2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester hydrochloride, the 5-hydroxytryptamin1A antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine hydrobromide and the polyamines depletor reserpine.
Negative_regulation (prevented) of acetylcholine depletor hemicholinium-3 associated with antinociception, antagonist, agonist, narcan and opioid
1) Confidence 0.41 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9495837 Disease Relevance 0 Pain Relevance 0.88

General Comments

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