INT73959

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Context Info
Confidence 0.61
First Reported 1998
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 49
Total Number 49
Disease Relevance 31.10
Pain Relevance 11.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOSTRIN) cytoplasmic membrane-bounded vesicle (NOSTRIN) plasma membrane (NOSTRIN)
cytoskeleton (NOSTRIN) cytoplasm (NOSTRIN)
Anatomy Link Frequency
blood 3
macrophages 2
bowel 2
microglia 2
endothelial cells 2
NOSTRIN (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 11 100.00 Very High Very High Very High
cytokine 166 99.96 Very High Very High Very High
COX2 9 99.90 Very High Very High Very High
potassium channel 2 99.84 Very High Very High Very High
Calcitonin gene-related peptide 1 99.82 Very High Very High Very High
metalloproteinase 18 99.64 Very High Very High Very High
Paracetamol 13 99.32 Very High Very High Very High
Leflunomide 10 98.94 Very High Very High Very High
Inflammation 386 98.76 Very High Very High Very High
Inflammatory mediators 24 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 80 99.68 Very High Very High Very High
Pressure Volume 2 Under Development 7 99.20 Very High Very High Very High
Amyloid Plaque 4 99.20 Very High Very High Very High
Apoptosis 86 99.06 Very High Very High Very High
Arthritis 93 99.00 Very High Very High Very High
Injury 301 98.84 Very High Very High Very High
INFLAMMATION 476 98.72 Very High Very High Very High
Heart Failure 43 98.32 Very High Very High Very High
Coronary Artery Disease 21 98.08 Very High Very High Very High
Disease 277 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION(S): This study has shown that endothelial nitric oxide synthase is changed in a phase-dependent manner during the menstrual cycle.
Positive_regulation (changed) of endothelial nitric oxide synthase
1) Confidence 0.61 Published 1998 Journal Fertil. Steril. Section Body Doc Link 9496346 Disease Relevance 0.11 Pain Relevance 0
We showed that the excitotoxin-induced microglia reaction, the expression of inducible nitric oxide synthase-positive cells and the production of interleukin-1beta and prostaglandin-E2 in the injected area were attenuated by the NO-flurbiprofen (15 mg/kg, p.o.) treatment.
Positive_regulation (inducible) of nitric oxide synthase-positive in microglia
2) Confidence 0.48 Published 2001 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11459126 Disease Relevance 0.60 Pain Relevance 0.21
Activation of extracellular signal-regulated protein kinase, endothelial nitric oxide synthase, and protein kinase B were assessed by Western blot analysis.
Positive_regulation (Activation) of nitric oxide synthase
3) Confidence 0.26 Published 2009 Journal Anesthesiology Section Body Doc Link 19104173 Disease Relevance 0 Pain Relevance 0
It may be through activation of the cytokines selective inhibition of inducible nitric oxide synthase which has been shown to reduce the progression of experimental osteoarthritis in vivo [37].
Positive_regulation (inducible) of nitric oxide synthase associated with osteoarthritis and cytokine
4) Confidence 0.20 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2526991 Disease Relevance 0.94 Pain Relevance 0.39
PLC-induced dilatative adaptation, and growth was found associated with increased inducible nitric oxide synthase and reduced arterial vascular endothelial growth factor and intracellular adhesion molecule-1 expression.
Positive_regulation (increased) of nitric oxide synthase
5) Confidence 0.19 Published 2010 Journal Arterioscler. Thromb. Vasc. Biol. Section Body Doc Link 20056909 Disease Relevance 0.07 Pain Relevance 0
PLC increased endothelial and human umbilical vascular endothelial cell proliferation and rapidly reduced inducible nitric oxide synthase and NADPH-oxidase 4-mediated reactive oxygen species production in human umbilical vascular endothelial cells; NADPH-oxidase 4 also regulated NF-kappaB-independent intracellular adhesion molecule-1 expression.
Positive_regulation (inducible) of nitric oxide synthase in endothelial cell
6) Confidence 0.19 Published 2010 Journal Arterioscler. Thromb. Vasc. Biol. Section Body Doc Link 20056909 Disease Relevance 0.05 Pain Relevance 0
On the contrary, nitric oxide production, endothelial nitric oxide synthase activity, and protein kinase B phosphorylation were enhanced by propofol treatment.
Positive_regulation (enhanced) of nitric oxide synthase
7) Confidence 0.19 Published 2009 Journal Anesthesiology Section Body Doc Link 19104173 Disease Relevance 0 Pain Relevance 0
Scientific studies have shown that erythropoietin protects cardiomyocytes from apoptosis [58, 59] and that the mechanism appears to be upregulation of endothelial nitric oxide synthase [60].
Positive_regulation (upregulation) of endothelial nitric oxide synthase in cardiomyocytes associated with apoptosis
8) Confidence 0.18 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3021842 Disease Relevance 1.21 Pain Relevance 0.04
Although they were shown to confer up to 300% protection against HD (in terms of median lethal concentration), this protection was not mediated through nitric oxide synthase inhibition.41–43 While these findings were in themselves interesting, what was also intriguing was that the efficacy of L-NAME in cultures treated after HD exposure, remained maximal at 3 hours post–HD treatment, and then only slowly declined over the next 5 hours.
Neg (not) Positive_regulation (mediated) of nitric oxide synthase
9) Confidence 0.15 Published 2008 Journal Eplasty Section Body Doc Link PMC2374499 Disease Relevance 0.54 Pain Relevance 0
PLC-induced dilatative adaptation, and growth was found associated with increased inducible nitric oxide synthase and reduced arterial vascular endothelial growth factor and intracellular adhesion molecule-1 expression.
Positive_regulation (inducible) of nitric oxide synthase
10) Confidence 0.13 Published 2010 Journal Arterioscler. Thromb. Vasc. Biol. Section Body Doc Link 20056909 Disease Relevance 0.07 Pain Relevance 0
In IBS patients, increased cellularity and proximity of the inflammatory or immune cells to the nerve trunks of the bowel, elevated interleukin-1beta mRNA expression in mucosal biopsies, and increased inducible nitric oxide synthase and nitrotyrosine elaboration (indicative of lymphocyte activation) were observed.
Positive_regulation (increased) of nitric oxide synthase in bowel associated with inflammation and spastic colon
11) Confidence 0.11 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 15893125 Disease Relevance 0.82 Pain Relevance 0.95
In IBS patients, increased cellularity and proximity of the inflammatory or immune cells to the nerve trunks of the bowel, elevated interleukin-1beta mRNA expression in mucosal biopsies, and increased inducible nitric oxide synthase and nitrotyrosine elaboration (indicative of lymphocyte activation) were observed.
Positive_regulation (inducible) of nitric oxide synthase in bowel associated with inflammation and spastic colon
12) Confidence 0.11 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 15893125 Disease Relevance 0.82 Pain Relevance 0.95
This compound exerted acute and chronic anti-inflammatory effects by oral route, that may be related with several mechanisms such as attenuation of leukocyte activation, inhibition of inducible nitric oxide synthase, cyclo-oxygenase-2 and cytosolic phospholipase A(2) expression as well as reduction in tumour necrosis factor-alpha production.
Positive_regulation (inducible) of nitric oxide synthase in leukocyte associated with necrosis, inflammation and cancer
13) Confidence 0.11 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12732367 Disease Relevance 0.52 Pain Relevance 0.31
This was also previously observed in induced nitric oxide synthase and nitrotyrosine expression [35].
Positive_regulation (induced) of nitric oxide synthase
14) Confidence 0.11 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 0.47 Pain Relevance 0.08
It has been suggested that resistin inhibits endothelial nitric oxide synthase activation in vitro and increases superoxide radical production in porcine coronary arteries [35] and human endothelial cells [26], thus reducing NO bio-availability.
Positive_regulation (activation) of endothelial nitric oxide synthase in endothelial cells
15) Confidence 0.10 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.79 Pain Relevance 0.15
stimulation of endothelial nitric oxide synthase (eNOS) and Na+,K+-ATPase

[26].

Positive_regulation (stimulation) of endothelial nitric oxide synthase
16) Confidence 0.10 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2266809 Disease Relevance 0.72 Pain Relevance 0.04
Bile salts and acid are likely to early induce COX-2 in this sequence, although other factors, such as proinflammatory cytokines, inducible nitric oxide synthase and growth factors such as TGF-beta, are potential COX-2 inducers in the esophagus.
Positive_regulation (inducible) of nitric oxide synthase in Bile associated with bile and cytokine
17) Confidence 0.09 Published 2003 Journal Curr. Pharm. Des. Section Abstract Doc Link 14552327 Disease Relevance 0.95 Pain Relevance 0.24
This was accompanied by lower activity of nuclear factor kappa B (NF-kappaB), higher expression of transforming growth factor beta in the colons and lower expression of inducible nitric oxide synthase in the tumors of fat-1 animals.
Positive_regulation (inducible) of nitric oxide synthase in colons associated with cancer
18) Confidence 0.09 Published 2007 Journal Carcinogenesis Section Abstract Doc Link 17634405 Disease Relevance 1.13 Pain Relevance 0.22
Furthermore, leflunomide inhibited the APAP-mediated increased expression of inducible nitric oxide synthase and prevented the formation of peroxynitrite, as judged from the absence of hepatic nitrotyrosine adducts.
Positive_regulation (inducible) of nitric oxide synthase associated with paracetamol and leflunomide
19) Confidence 0.06 Published 2007 Journal Hepatology Section Abstract Doc Link 17366662 Disease Relevance 0.47 Pain Relevance 1.17
(Nitric oxide from inducible nitric oxide synthase, produced abundantly in rodent glia, may be less important in human tissues.)
Positive_regulation (inducible) of nitric oxide synthase
20) Confidence 0.06 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC545943 Disease Relevance 1.21 Pain Relevance 0.58

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