INT7396

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Context Info
Confidence 0.62
First Reported 1981
Last Reported 2010
Negated 3
Speculated 14
Reported most in Abstract
Documents 81
Total Number 94
Disease Relevance 6.57
Pain Relevance 31.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1)
cell-cell signaling (GNRH1)
Anatomy Link Frequency
hypothalamus 18
pituitary 13
neurons 12
MPOA 5
gonadal 4
GNRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 210 100.00 Very High Very High Very High
agonist 133 100.00 Very High Very High Very High
antagonist 105 100.00 Very High Very High Very High
Dopamine 73 100.00 Very High Very High Very High
opiate 53 100.00 Very High Very High Very High
gABA 31 100.00 Very High Very High Very High
Opioid 116 99.98 Very High Very High Very High
Endogenous opioid 59 99.98 Very High Very High Very High
Somatostatin 3 99.92 Very High Very High Very High
MU agonist 5 99.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Galactorrhea 43 99.92 Very High Very High Very High
Anovulation 5 99.48 Very High Very High Very High
Bordatella Infection 5 98.80 Very High Very High Very High
Endometriosis (extended) 4 98.00 Very High Very High Very High
Disease 27 97.48 Very High Very High Very High
Reprotox - General 2 7 97.02 Very High Very High Very High
Urological Neuroanatomy 29 96.44 Very High Very High Very High
Reprotox - General 1 39 95.40 Very High Very High Very High
Ovarian Cancer 2 94.52 High High
Hyperandrogenism 1 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Direct connections of the GnRH neurons demonstrated so far does not exclude the possibility that these neurotransmitters or neuromodulators influence GnRH release also at other levels of the CNS.
Regulation (influence) of Localization (release) of GnRH in neurons associated with neurotransmitter
1) Confidence 0.62 Published 1989 Journal J. Steroid Biochem. Section Abstract Doc Link 2513450 Disease Relevance 0 Pain Relevance 0.18
The present results showed that steroid hormones and opiate receptor agonists influence irGnRH release from human cultured cells, suggesting that local interaction between steroids and peptides modulates irGnRH release from human placenta.
Regulation (modulates) of Localization (release) of irGnRH in placenta associated with agonist and opiate
2) Confidence 0.62 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2156890 Disease Relevance 0 Pain Relevance 0.56
Endogenous opioid regulation of GnRH release from the human fetal (21-23 weeks gestation) mediobasal hypothalamus was investigated in an in vitro perifusion system.
Spec (investigated) Regulation (regulation) of Localization (release) of GnRH in hypothalamus associated with endogenous opioid
3) Confidence 0.61 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6311863 Disease Relevance 0 Pain Relevance 0.48
If current evidence is correct, and only a single gonadotropin-releasing hormone exists, then mechanisms to differentially regulate the three gonadotropin genes may involve changes in GnRH secretion.
Regulation (changes) of Localization (secretion) of GnRH
4) Confidence 0.61 Published 1991 Journal Recent Prog. Horm. Res. Section Abstract Doc Link 1745819 Disease Relevance 0 Pain Relevance 0
Neuroendocrine control of pulsatile GnRH secretion during the ovarian cycle: evidence from the ewe.
Regulation (control) of Localization (secretion) of GnRH associated with narcan
5) Confidence 0.61 Published 2002 Journal Reprod. Suppl. Section Title Doc Link 12698972 Disease Relevance 0 Pain Relevance 0.26
This article reviews the neuroendocrine control of episodic GnRH secretion during the ovine oestrous cycle.
Regulation (control) of Localization (secretion) of GnRH
6) Confidence 0.61 Published 2002 Journal Reprod. Suppl. Section Abstract Doc Link 12698972 Disease Relevance 0 Pain Relevance 0.19
It is well known that endogenous opioid peptides exert a tonic inhibitory control on GnRH release, leading to the inhibition of LH secretion, whereas eicosanoids, particularly prostaglandin E2(PGE2), stimulate GnRH output.
Regulation (control) of Localization (release) of GnRH associated with endogenous opioid
7) Confidence 0.61 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8626832 Disease Relevance 0 Pain Relevance 0.41
In addition to these effects on GnRH release during a pulse, naloxone increased the amount of GnRH collected between pulses in both experiments.
Regulation (effects) of Localization (release) of GnRH associated with narcan
8) Confidence 0.61 Published 1995 Journal Endocrinology Section Abstract Doc Link 7750462 Disease Relevance 0 Pain Relevance 0.50
The CNS controls reproduction through pulsatile secretion of gonadotropin-releasing hormone (GnRH).
Regulation (controls) of Localization (secretion) of GnRH
9) Confidence 0.60 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11431490 Disease Relevance 0 Pain Relevance 0
This control is most likely to be at the level of the hypothalamus, and involves modulation of pulsatile LHRH release.
Regulation (modulation) of Localization (release) of LHRH in hypothalamus
10) Confidence 0.60 Published 1981 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6784982 Disease Relevance 0.16 Pain Relevance 0.59
Adrenergic and dopaminergic regulation of gonadotropin-releasing hormone release from goldfish preoptic-anterior hypothalamus and pituitary in vitro.
Regulation (regulation) of in pituitary Localization (release) of gonadotropin-releasing hormone in hypothalamus
11) Confidence 0.58 Published 1992 Journal Gen. Comp. Endocrinol. Section Title Doc Link 1348716 Disease Relevance 0 Pain Relevance 0.44
The above results suggest that: (a) the delta-opioid agonist DTLET modulates GnRH release differentially in the hypothalamic areas examined; and (b) the arachidonic acid metabolites are involved in the mode of action of DTLET on the release of GnRH in the ARN plus ME hypothalamic fragment.
Regulation (modulates) of Spec (examined) Localization (release) of GnRH in ARN associated with mu agonist
12) Confidence 0.57 Published 1993 Journal Brain Res. Section Abstract Doc Link 8281433 Disease Relevance 0 Pain Relevance 0.36
They may also influence the degree of sialylation and subsequent biologic activity of the gonadotropins. (3) GnRH release is under the control of catecholaminergic neurotransmitters.
Regulation (under) of Localization (release) of GnRH associated with neurotransmitter
13) Confidence 0.55 Published 1982 Journal Fertil. Steril. Section Abstract Doc Link 6127237 Disease Relevance 0 Pain Relevance 0.28
Gonadotropin-releasing hormone (GnRH) secretion is modulated by a large number of neuromediators, among which catecholamines play a central role.
Regulation (modulated) of Localization (secretion) of GnRH associated with catecholamine
14) Confidence 0.54 Published 1996 Journal Life Sci. Section Abstract Doc Link 8622571 Disease Relevance 0 Pain Relevance 0.21
The aim of the present study was to evaluate whether steroid hormones or opiate receptor agonists participate in the mechanisms regulating the release of immunoreactive GnRH (irGnRH) from cultured human placental cells.
Spec (whether) Regulation (regulating) of Localization (release) of irGnRH associated with agonist and opiate
15) Confidence 0.54 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2156890 Disease Relevance 0 Pain Relevance 0.15
However, a role for delta-opioid receptors in the regulation of gonadotrophin releasing hormone (GnRH) secretion has recently been suggested.
Regulation (regulation) of Localization (secretion) of GnRH associated with delta opioid receptors
16) Confidence 0.52 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9647539 Disease Relevance 0 Pain Relevance 0.43
Endogenous opioid peptides tonically inhibit LH by acting on hypothalamic mechanisms which regulate LHRH secretion.
Regulation (regulate) of Localization (secretion) of LHRH associated with endogenous opioid
17) Confidence 0.51 Published 1986 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3621624 Disease Relevance 0 Pain Relevance 0.55
Neuropeptides mainly involved in the control of GnRH release are opioids, neuropeptide Y (NPY), galanin, and corticotropin-releasing factor (CRF), whereas neurotransmitters are noradrenaline, dopamine, serotonin, melatonin and gamma-aminobutyric acid (GABA).
Regulation (control) of Localization (release) of GnRH associated with gaba, dopamine, neurotransmitter, noradrenaline, neuropeptide, serotonin and opioid
18) Confidence 0.51 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10818386 Disease Relevance 0 Pain Relevance 0.82
The results provide in vivo evidence supporting a role for OFQ in the control of GnRH secretion and raise the possibility that it acts as part of an ultrashort, autocrine feedback loop controlling GnRH pulses.
Regulation (control) of Localization (secretion) of GnRH
19) Confidence 0.50 Published 2007 Journal Endocrinology Section Abstract Doc Link 17615146 Disease Relevance 0 Pain Relevance 0.22
Neural circuits involved in the control of LHRH secretion: a model for estrous cycle regulation.
Regulation (control) of Localization (secretion) of LHRH in Neural associated with narcan
20) Confidence 0.48 Published 1985 Journal J. Steroid Biochem. Section Title Doc Link 2934578 Disease Relevance 0 Pain Relevance 0.24

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