INT73961

Context Info Confidence 0.01 First Reported 1997 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.39 Pain Relevance 0

nucleus (NXT1) intracellular (NXT1) cytoplasm (NXT1)

Anatomy Link Frequency upper 1 urine 1 NXT1 (Homo sapiens)

Pain Link Frequency Relevance Heat cva 1 17.28 dexamethasone 7 5.00 Pain 3 5.00 Spinal cord 2 5.00

Disease Link Frequency Relevance Heat Multiple Myeloma 26 75.44 Pain 3 72.32 Disease 6 71.80 Metastasis 1 58.24 Hypercalcemia 11 56.92 Osteoporosis 47 50.00 Bone Cancer 3 50.00 Cv General 3 Under Development 1 17.28 Hemorrhage 1 12.56 Osteolysis 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Changes in serum or urine levels of bALP, PINP, DKK-1, NTX-I, PTH and calcium were analyzed by comparison of the value of each marker at a given time point with the same marker pre-treatment using a Wilcoxon signed rank test.

Regulation (Changes) of NTX-I in urine

1) Confidence 0.01 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0 Pain Relevance 0

Symptomatic response to pamidronate correlated closely with the rate of bone resorption; it was more frequent in those patients with an initial NTx value of < 2 times the upper limit of normal (17 of 27, 62%) and in those where the level of Ntx returned to normal (19 of 32, 59%), than in the patients with either high baseline values of NTx (> 2 times the upper limit of normal) or Ntx levels which failed to normalise for whom the response frequencies were 2 of 16 (13%) and 0 of 11 (0%), respectively.

Regulation (value) of NTx in upper

2) Confidence 0.01 Published 1997 Journal Ann. Oncol. Section Body Doc Link 9496390 Disease Relevance 0.17 Pain Relevance 0

No changes of NTx, IL-6, beta2-microglobulin, CRP or skeletal events were observed in patients of group II, while paraprotein was significantly reduced after 6 months of treatment.

Neg (No) Regulation (changes) of NTx

3) Confidence 0.00 Published 2000 Journal Eur. J. Haematol. Section Body Doc Link 11092464 Disease Relevance 0.22 Pain Relevance 0

General Comments

This test has worked.