INT73961

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Context Info
Confidence 0.01
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NXT1) intracellular (NXT1) cytoplasm (NXT1)
Anatomy Link Frequency
upper 1
urine 1
NXT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 1 17.28 Low Low
dexamethasone 7 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Myeloma 26 75.44 Quite High
Pain 3 72.32 Quite High
Disease 6 71.80 Quite High
Metastasis 1 58.24 Quite High
Hypercalcemia 11 56.92 Quite High
Osteoporosis 47 50.00 Quite Low
Bone Cancer 3 50.00 Quite Low
Cv General 3 Under Development 1 17.28 Low Low
Hemorrhage 1 12.56 Low Low
Osteolysis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in serum or urine levels of bALP, PINP, DKK-1, NTX-I, PTH and calcium were analyzed by comparison of the value of each marker at a given time point with the same marker pre-treatment using a Wilcoxon signed rank test.
Regulation (Changes) of NTX-I in urine
1) Confidence 0.01 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0 Pain Relevance 0
Symptomatic response to pamidronate correlated closely with the rate of bone resorption; it was more frequent in those patients with an initial NTx value of < 2 times the upper limit of normal (17 of 27, 62%) and in those where the level of Ntx returned to normal (19 of 32, 59%), than in the patients with either high baseline values of NTx (> 2 times the upper limit of normal) or Ntx levels which failed to normalise for whom the response frequencies were 2 of 16 (13%) and 0 of 11 (0%), respectively.
Regulation (value) of NTx in upper
2) Confidence 0.01 Published 1997 Journal Ann. Oncol. Section Body Doc Link 9496390 Disease Relevance 0.17 Pain Relevance 0
No changes of NTx, IL-6, beta2-microglobulin, CRP or skeletal events were observed in patients of group II, while paraprotein was significantly reduced after 6 months of treatment.
Neg (No) Regulation (changes) of NTx
3) Confidence 0.00 Published 2000 Journal Eur. J. Haematol. Section Body Doc Link 11092464 Disease Relevance 0.22 Pain Relevance 0

General Comments

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