INT7397

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 86
Total Number 89
Disease Relevance 15.45
Pain Relevance 29.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1)
cell-cell signaling (GNRH1)
Anatomy Link Frequency
pituitary 22
hypothalamus 15
neural 8
gonadal 6
follicle 6
GNRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 169 100.00 Very High Very High Very High
narcan 91 100.00 Very High Very High Very High
Endogenous opioid 53 100.00 Very High Very High Very High
opiate 49 100.00 Very High Very High Very High
Dopamine 100 99.98 Very High Very High Very High
Opioid 86 99.98 Very High Very High Very High
Dynorphin 29 99.76 Very High Very High Very High
agonist 173 99.68 Very High Very High Very High
Morphine 10 99.40 Very High Very High Very High
Clonidine 12 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Trypanosomiasis 3 99.98 Very High Very High Very High
Reprotox - General 1 127 99.90 Very High Very High Very High
Stress 374 99.82 Very High Very High Very High
Galactorrhea 24 99.76 Very High Very High Very High
Reprotox - General 2 29 99.40 Very High Very High Very High
Hypogonadotropic Hypogonadism 188 98.44 Very High Very High Very High
Aids-related Complex 4 97.88 Very High Very High Very High
Anovulation 17 97.18 Very High Very High Very High
Disease 59 96.24 Very High Very High Very High
Polycystic Ovary Syndrome 33 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data also demonstrate that human hypothalamic pulsatile GnRH release can be suppressed by an opiate receptor-mediated mechanism located within the MBH.
Negative_regulation (suppressed) of Localization (release) of GnRH in MBH associated with opiate
1) Confidence 0.59 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2657474 Disease Relevance 0 Pain Relevance 0.43
However, both morphine and UP50, 488H significantly inhibited 8-bromo-cAMP-induced GnRH release.
Negative_regulation (inhibited) of Localization (release) of GnRH associated with morphine
2) Confidence 0.59 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2156890 Disease Relevance 0 Pain Relevance 0.69
The mechanisms involved in inhibiting GnRH release remain unclear in humans.
Negative_regulation (inhibiting) of Localization (release) of GnRH
3) Confidence 0.58 Published 1991 Journal Recent Prog. Horm. Res. Section Abstract Doc Link 1745819 Disease Relevance 0 Pain Relevance 0.15
During the first year, GnRH secretion is inhibited and both the amplitude and apparent frequency of pulsatile release is markedly reduced.
Negative_regulation (inhibited) of Localization (secretion) of GnRH
4) Confidence 0.58 Published 1991 Journal Recent Prog. Horm. Res. Section Abstract Doc Link 1745819 Disease Relevance 0 Pain Relevance 0.13
Involvement of the endogenous opioids in the pathophysiology of hypothalamic amenorrhea, by inhibition of hypothalamic GnRH secretion, has been demonstrated in some cases.
Negative_regulation (inhibition) of Localization (secretion) of GnRH associated with endogenous opioid and reprotox - general 1
5) Confidence 0.58 Published 1992 Journal Acta Endocrinol. Section Abstract Doc Link 1621484 Disease Relevance 0.81 Pain Relevance 0.33
Antagonists inhibited the release of hCG and GnRH and totally reversed the effect of agonists, i.e., their effect is kappa receptor mediated.
Negative_regulation (inhibited) of Localization (release) of GnRH associated with antagonist and agonist
6) Confidence 0.58 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8114013 Disease Relevance 0 Pain Relevance 0.77
We conclude that the effective cycloxygenase blockade inhibits the stimulatory activity of naloxone on LH release, suggesting that the inhibitory tone of opioids on GnRH secretion may be caused by the block of hypothalamic prostaglandin biosynthesis with consequent inhibition of PGE2-induced GnRH secretion.
Negative_regulation (inhibition) of Localization (secretion) of GnRH associated with narcan and opioid
7) Confidence 0.58 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8626832 Disease Relevance 0 Pain Relevance 0.50
Stress, via the release of corticotropin-releasing factor (CRF), eventually triggered by interleukin 1, inhibits GnRH release, resulting in hypogonadism.
Negative_regulation (inhibits) of Localization (release) of GnRH associated with reprotox - general 2 and stress
8) Confidence 0.57 Published 1993 Journal Environ Health Perspect Section Abstract Doc Link PMC1519927 Disease Relevance 1.12 Pain Relevance 0.18
According to the "gonadostat " theory, the low levels of testosterone/estradiol released by the prepubertal testes/ovaries exert negative feedback effects that inhibit GnRH secretion [20].
Negative_regulation (inhibit) of Localization (secretion) of GnRH in testes
9) Confidence 0.57 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2958977 Disease Relevance 0.06 Pain Relevance 0.17
The effects of DA antagonists (1 microM) were also tested: in P-AH slices, addition of SKF-83566 (D1-antagonist) significantly reduced spontaneous GnRH release; pimozide and domperidone (D2-antagonist) were ineffective when tested alone.
Negative_regulation (reduced) of Localization (release) of GnRH associated with dopamine and antagonist
10) Confidence 0.55 Published 1992 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 1348716 Disease Relevance 0 Pain Relevance 0.91
On the other hand, D2-agonists, but not D1-agonists, significantly reduced GnRH release from pituitary fragments.
Negative_regulation (reduced) of Localization (release) of GnRH in pituitary associated with agonist
11) Confidence 0.55 Published 1992 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 1348716 Disease Relevance 0 Pain Relevance 0.97
Incubation of P-AH slices with phentolamine (alpha 1/alpha 2-antagonist) and prazosin (alpha 1-antagonist), at a concentration of 1 microM, inhibited the release of GnRH induced by NE (60 microM); the alpha 2-antagonist yombibin and the beta-antagonist propanolol were ineffective.
Negative_regulation (inhibited) of Localization (release) of GnRH associated with antagonist
12) Confidence 0.55 Published 1992 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 1348716 Disease Relevance 0 Pain Relevance 0.74
The effects of some DA agonists (1 microM) were tested: apomorphine (D1/D2-agonist) and SKF 38398 (D1-agonist), but not bromocriptine and LY-171555 (D2-agonists) significantly reduced spontaneous GnRH release from P-AH slices in vitro.
Negative_regulation (reduced) of Localization (release) of GnRH associated with dopamine and agonist
13) Confidence 0.55 Published 1992 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 1348716 Disease Relevance 0 Pain Relevance 0.99
Spontaneous release of GnRH from both P-AH slices and pituitary fragments was reduced by dopamine (DA) in a dose-related manner.
Negative_regulation (reduced) of Localization (release) of GnRH in pituitary associated with dopamine
14) Confidence 0.55 Published 1992 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 1348716 Disease Relevance 0 Pain Relevance 0.99
In this area Diallyl-G had no effect on the PGE2 release but blocked the GnRH secretion.
Negative_regulation (blocked) of Localization (secretion) of GnRH
15) Confidence 0.54 Published 1993 Journal Brain Res. Section Abstract Doc Link 8281433 Disease Relevance 0 Pain Relevance 0.37
The results, especially the lack of response to clonidine, indicate that trypanosomiasis impairs GnRH release from the hypothalamus.
Negative_regulation (impairs) of Localization (release) of GnRH in hypothalamus associated with trypanosomiasis and clonidine
16) Confidence 0.52 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9365802 Disease Relevance 0.29 Pain Relevance 0.46
GnRH secretion is more variable at night, suggesting that the mechanisms involved in reducing pulsatile GnRH secretion are less effective during sleep.
Negative_regulation (reducing) of Localization (secretion) of GnRH
17) Confidence 0.51 Published 1987 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2880864 Disease Relevance 0.17 Pain Relevance 0.42
In the presence of a steroid-sufficient environment (that is to say, in the luteal phase) beta-endorphin exerts a tonic inhibition on the secretion of GnRH and thereby on the LH-release.
Negative_regulation (inhibition) of Localization (secretion) of GnRH
18) Confidence 0.48 Published 1989 Journal Obstet Gynecol Surv Section Abstract Doc Link 2677858 Disease Relevance 0.14 Pain Relevance 0.43
The calcium-dependent pulsatile GnRH release from fetal human MBHs was suppressed by addition of morphine (10 microM) to the perifusion medium, and this suppression was reversed by addition of the opiate receptor antagonist naloxone (10 microM).
Negative_regulation (suppressed) of Localization (release) of GnRH associated with antagonist, narcan, opiate and morphine
19) Confidence 0.43 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2657474 Disease Relevance 0 Pain Relevance 0.42
Both estriol and estradiol augmented, while progesterone decreased, the irGnRH release induced by 8-bromo-cAMP.
Negative_regulation (decreased) of Localization (release) of irGnRH
20) Confidence 0.43 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2156890 Disease Relevance 0 Pain Relevance 0.36

General Comments

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