INT73976

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 7.92
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90aa1) protein folding (Hsp90aa1) cytosol (Hsp90aa1)
ATPase activity (Hsp90aa1) intracellular (Hsp90aa1) response to stress (Hsp90aa1)
Anatomy Link Frequency
brain 2
Hsp90aa1 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 6 81.20 Quite High
Hippocampus 15 79.84 Quite High
midbrain 24 78.80 Quite High
agonist 36 78.28 Quite High
Spinal cord 3 77.68 Quite High
Potency 9 69.72 Quite High
Calcium channel 28 60.96 Quite High
cytokine 14 50.00 Quite Low
addiction 14 50.00 Quite Low
Osteoarthritis 8 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 377 99.84 Very High Very High Very High
Apoptosis 52 99.72 Very High Very High Very High
Shock 509 99.00 Very High Very High Very High
Synovial Sarcoma 105 96.32 Very High Very High Very High
Melanoma 6 90.72 High High
Breast Cancer 13 89.92 High High
Ovarian Cancer 3 88.40 High High
Leukemia 9 88.08 High High
Stress 102 87.24 High High
Disease 88 86.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression pattern of Hsp90aa1 and Hsph1 was confirmed by RT-PCR.
Gene_expression (expression) of Hsp90aa1
1) Confidence 0.75 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 1.27 Pain Relevance 0
(40), Hsp25, Hsp70, Hsp86, Hsp110 but not Hsp65 were observed in wild-type mice after HS; the increases in all of the proteins were PPAR?
Neg (not) Gene_expression (not) of Hsp86 associated with shock
2) Confidence 0.65 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.68 Pain Relevance 0
(40), Hsp25, Hsp70, Hsp86, Hsp110 but not Hsp65 were observed in wild-type mice after HS; the increases in all of the proteins were PPAR?
Gene_expression (observed) of Hsp86 associated with shock
3) Confidence 0.65 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.68 Pain Relevance 0
Experiments also revealed that expression levels of Hsp90 remained constant with varying PU-H71 concentrations but Hsp70 levels increased in response to Hsp90 inhibition at concentrations of approximately 0.1–0.25 µM.


Gene_expression (expression) of Hsp90
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.34 Pain Relevance 0
Furthermore, the expression of IL-1 beta, IL-6, TNF-alpha and IFN-gamma mRNA was associated with expression of HSP60, HSP47, HSP70 and HSP70/HSP86 mRNA, respectively.
Gene_expression (expression) of HSP86
5) Confidence 0.54 Published 1997 Journal Osteoarthr. Cartil. Section Body Doc Link 9497939 Disease Relevance 0.06 Pain Relevance 0
0.25 µM, decreased expression levels of Hsp90 client onco-proteins including HER2/neu, Akt and RAF1, compared to DMSO-treated controls.
Gene_expression (expression) of Hsp90
6) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.15 Pain Relevance 0
In each case, expression levels of the Hsp90-independent protein ?
Gene_expression (levels) of Hsp90
7) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.14 Pain Relevance 0
For example, the inducible Hsp70 (Hspa1a) is present at extremely low levels in brain, whereas the constitutively expressed Hsp90, Hsc70 an Hsp60 are easily detected [90].
Gene_expression (detected) of Hsp90 in brain
8) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.06 Pain Relevance 0.16
For example, the inducible Hsp70 (Hspa1a) is present at extremely low levels in brain, whereas the constitutively expressed Hsp90, Hsc70 an Hsp60 are easily detected [90].
Gene_expression (expressed) of Hsp90 in brain
9) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.06 Pain Relevance 0.15
Lamb et al. found, via high connectivity scores with GDA, 17-AAG, and 17-DMAG, that gedunin exhibited its antiproliferative activity through Hsp90 modulation.
Gene_expression (modulation) of Hsp90
10) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.15 Pain Relevance 0.07
Our preliminary results suggested the HIFU treatments caused significant up-regulations of HSP70 and HSP90 expression in tumor cells, in which 55°C-HIFU was more effective than 80°C-HIFU (Data not shown).
Gene_expression (expression) of HSP90 associated with cancer
11) Confidence 0.37 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.88 Pain Relevance 0.03
However, among the 35 genes that are uniformly highly expressed are several essential house-keeping genes such as Hsc70, BiP, Hsp90, calreticulin, and calnexin.
Gene_expression (expressed) of Hsp90
12) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.08 Pain Relevance 0
The mRNA expression levels of BiP, Hsp40, and Hsp90 were increased up to 1.8-fold, 1.8-fold, and 1.9-fold, respectively, after a 7-d treatment with diltiazem, whereas the mRNA expression levels of Hsp70, GRP94, calnexin, and calreticulin were not changed significantly.
Gene_expression (expression) of Hsp90
13) Confidence 0.26 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0
The increased protein expression levels of BiP, Hsp40, and Hsp90 were confirmed after a 7-d treatment with diltiazem.
Gene_expression (expression) of Hsp90
14) Confidence 0.23 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0.03
Messenger RNAs (mRNAs) for HSPs (HSP32, HSP47, HSP60, HSP70, HSP84 and HSP86) and cytokines [interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma)] were detected by reverse transcription-polymerase chain reaction (RT-PCR).
Gene_expression (detected) of HSP86
15) Confidence 0.21 Published 1997 Journal Osteoarthr. Cartil. Section Body Doc Link 9497939 Disease Relevance 0.09 Pain Relevance 0
The mRNA expression levels of BiP, Hsp40, and Hsp90 were increased up to 1.8-fold, 1.8-fold, and 1.9-fold, respectively, after a 7-d treatment with diltiazem, whereas the mRNA expression levels of Hsp70, GRP94, calnexin, and calreticulin were not changed significantly.
Gene_expression (levels) of Hsp90
16) Confidence 0.21 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0
The relative mRNA expression levels of representative cytoplasmic and ER lumenal chaperones—including Hsp40, Hsp70, BiP, Hsp90, GRP94, calnexin, calreticulin, HIP, and HOP—were probed and normalized to the levels found in untreated cells (Figure 4A).
Gene_expression (expression) of Hsp90
17) Confidence 0.21 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0
The Hsp90 inhibitor 17-AAG has completed phase I
Gene_expression (The) of Hsp90
18) Confidence 0.20 Published 2009 Journal Sarcoma Section Body Doc Link PMC2659882 Disease Relevance 1.19 Pain Relevance 0
The Hsp90 inhibitor 17-AAG has completed phase I
Gene_expression (inhibitor) of Hsp90
19) Confidence 0.20 Published 2009 Journal Sarcoma Section Body Doc Link PMC2659882 Disease Relevance 1.19 Pain Relevance 0
To date, synergy studies using Hsp90
Gene_expression (using) of Hsp90
20) Confidence 0.17 Published 2009 Journal Sarcoma Section Body Doc Link PMC2659882 Disease Relevance 0.89 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox