INT73977

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Context Info
Confidence 0.54
First Reported 1997
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 8.14
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Serpinh1) endoplasmic reticulum (Serpinh1) protein maturation (Serpinh1)
response to stress (Serpinh1) cytoplasm (Serpinh1)
Anatomy Link Frequency
cornea 3
joints 2
extracellular matrix 2
endothelium 2
lens 2
Serpinh1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 14 100.00 Very High Very High Very High
fibrosis 58 87.96 High High
Inflammation 49 80.00 Quite High
tolerance 32 71.60 Quite High
cytokine 24 50.00 Quite Low
Osteoarthritis 10 50.00 Quite Low
anesthesia 26 5.00 Very Low Very Low Very Low
ketamine 18 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
metalloproteinase 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stomach Cancer 116 99.84 Very High Very High Very High
Cataract 160 97.96 Very High Very High Very High
Wound Healing 97 94.12 High High
Fracture Healing 64 92.16 High High
Shock 126 90.92 High High
Fibrosis 62 87.96 High High
Targeted Disruption 112 87.92 High High
Osteoarthritis 12 86.96 High High
Corneal Neovascularization 8 85.56 High High
Hyphema 8 83.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the expression of IL-1 beta, IL-6, TNF-alpha and IFN-gamma mRNA was associated with expression of HSP60, HSP47, HSP70 and HSP70/HSP86 mRNA, respectively.
Gene_expression (expression) of HSP47
1) Confidence 0.54 Published 1997 Journal Osteoarthr. Cartil. Section Body Doc Link 9497939 Disease Relevance 0.06 Pain Relevance 0
Messenger RNAs (mRNAs) for HSPs (HSP32, HSP47, HSP60, HSP70, HSP84 and HSP86) and cytokines [interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma)] were detected by reverse transcription-polymerase chain reaction (RT-PCR).
Gene_expression (detected) of HSP47
2) Confidence 0.42 Published 1997 Journal Osteoarthr. Cartil. Section Body Doc Link 9497939 Disease Relevance 0.09 Pain Relevance 0
SERPINH1 was also found to be significantly overexpressed in the PF7 and PF10 ESTs.
Gene_expression (overexpressed) of SERPINH1
3) Confidence 0.21 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1578570 Disease Relevance 0.24 Pain Relevance 0
Hsp 47 is normally expressed weakly in the limbus keratocytes and the entire endothelium, but was expressed strongly throughout all layers of the cornea 6 hr after heating and 12 hr after cooling, especially in the corneal basal cell layer and endothelium.
Gene_expression (expressed) of Hsp 47 in endothelium
4) Confidence 0.20 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0 Pain Relevance 0
Hsp 47 is normally expressed weakly in the limbus keratocytes and the entire endothelium, but was expressed strongly throughout all layers of the cornea 6 hr after heating and 12 hr after cooling, especially in the corneal basal cell layer and endothelium.
Gene_expression (expressed) of Hsp 47 in endothelium
5) Confidence 0.20 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0 Pain Relevance 0
In control Group N, Hsp 47 was not expressed in the lens epithelium.
Neg (not) Gene_expression (expressed) of Hsp 47 in lens epithelium
6) Confidence 0.20 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0 Pain Relevance 0
In light of these facts, the increased levels of Hsp 70 and Hsp 47 appeared to be major factors in the protection of the cornea and lens against lethal thermal damage, as well as played an important role in rapid wound healing, and decreased corneal and lens opacity after excimer laser ablation.
Gene_expression (levels) of Hsp 47 in lens associated with wound healing and cataract
7) Confidence 0.17 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 1.28 Pain Relevance 0.04
In the corneas of Group N there was no Hsp 47 induction.
Neg (no) Gene_expression (induction) of Hsp 47 in corneas
8) Confidence 0.17 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.74 Pain Relevance 0
Hsp 47 was not found in the central cornea and lens of the control group.
Neg (not) Gene_expression (found) of Hsp 47 in lens
9) Confidence 0.15 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.48 Pain Relevance 0.12
Our study identified a large number of genes associated with the extracellular matrix (SPARC, SERPINH1/HSP47, COL1A1, COL1A2, COL4A1, MMP3, TIMP1, PRSS2, CDH3, SPP1, IL8, CTSB, LUM, CEACAM, CTHRC1, SULF1, ASPN, SPON2 and CLDN18) and chemokine activity, to be differentially expressed in gastric cancers.
Gene_expression (expressed) of SERPINH1 in extracellular matrix associated with chemokine and stomach cancer
10) Confidence 0.10 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.39 Pain Relevance 0.05
Our study identified a large number of genes associated with the extracellular matrix (SPARC, SERPINH1/HSP47, COL1A1, COL1A2, COL4A1, MMP3, TIMP1, PRSS2, CDH3, SPP1, IL8, CTSB, LUM, CEACAM, CTHRC1, SULF1, ASPN, SPON2 and CLDN18) and chemokine activity, to be differentially expressed in gastric cancers.
Gene_expression (expressed) of HSP47 in extracellular matrix associated with chemokine and stomach cancer
11) Confidence 0.10 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.38 Pain Relevance 0.05
In light of these facts, the increased levels of Hsp 70 and Hsp 47 appeared to be major factors in the protection of the cornea and lens against lethal thermal damage, as well as played an important role in rapid wound healing, and decreased corneal and lens opacity after excimer laser ablation.
Gene_expression (levels) of Hsp 47 in cornea associated with wound healing and cataract
12) Confidence 0.06 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 1.28 Pain Relevance 0.04
Hsp 47 was not found in the central cornea and lens of the control group.
Neg (not) Gene_expression (found) of Hsp 47 in cornea
13) Confidence 0.05 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.48 Pain Relevance 0.12
In the synovium of NOC joints, intimal cells and occasional fibroblastic subsynovial cells were positive for HSP-47.
Gene_expression (positive) of HSP-47 in joints
14) Confidence 0.04 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468886 Disease Relevance 0.37 Pain Relevance 0.15
Immunostaining for HSP-47 was unaltered in any meniscectomized joints, and although a slight increase in intimal cell staining for TGF-?
Gene_expression (Immunostaining) of HSP-47 in joints
15) Confidence 0.04 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468886 Disease Relevance 0.35 Pain Relevance 0.14

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