INT73979

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Context Info
Confidence 0.61
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.68
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90ab1) protein folding (Hsp90ab1) cytosol (Hsp90ab1)
mitochondrion (Hsp90ab1) intracellular (Hsp90ab1) response to stress (Hsp90ab1)
Anatomy Link Frequency
liver 1
cartilage 1
brain 1
Hsp90ab1 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 2 99.54 Very High Very High Very High
Central grey 1 79.12 Quite High
Inflammation 122 78.68 Quite High
withdrawal 4 58.28 Quite High
anesthesia 1 56.60 Quite High
cytokine 22 54.00 Quite High
chemokine 7 52.76 Quite High
Osteoarthritis 8 50.00 Quite Low
Migraine 1 45.64 Quite Low
Inflammatory mediators 2 23.72 Low Low
Disease Link Frequency Relevance Heat
Shock 15 100.00 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 216 99.84 Very High Very High Very High
Demyelinating Disease 2 99.54 Very High Very High Very High
Stress 130 98.48 Very High Very High Very High
Disease 78 98.40 Very High Very High Very High
Osteoarthritis 10 86.12 High High
Cancer 20 81.76 Quite High
Urological Neuroanatomy 1 79.12 Quite High
INFLAMMATION 182 78.68 Quite High
Asthma 22 71.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The mRNA levels of HSP47, HSP70, HSP86, IL-6, and IFN-gamma were up-regulated in the cartilage of C57 black mice, whereas, the level of expression of HSP32, HSP60, HSP84 and IL-1 beta remained unchanged.
Gene_expression (expression) of HSP84 in cartilage
1) Confidence 0.61 Published 1997 Journal Osteoarthr. Cartil. Section Body Doc Link 9497939 Disease Relevance 0.07 Pain Relevance 0
In one study, it was shown that Snell dwarf liver tissue expressed less HSP70, HSP90, and HSP60 than was found in wild-type mice (Dozmorov et al. 2002).
Gene_expression (expressed) of HSP90 in liver
2) Confidence 0.46 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.71 Pain Relevance 0
The expression of HSP 84, transthyretin precursor, and OSI genes adds further evidence that oligemia induces an oxidative stress response in the brain.
Gene_expression (expression) of HSP 84 in brain associated with stress
3) Confidence 0.42 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15207916 Disease Relevance 0.53 Pain Relevance 0.13
Messenger RNAs (mRNAs) for HSPs (HSP32, HSP47, HSP60, HSP70, HSP84 and HSP86) and cytokines [interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma)] were detected by reverse transcription-polymerase chain reaction (RT-PCR).
Gene_expression (detected) of HSP84
4) Confidence 0.21 Published 1997 Journal Osteoarthr. Cartil. Section Body Doc Link 9497939 Disease Relevance 0.09 Pain Relevance 0
to the cytosol.58 However, although there is evidence for an elevation of Hsp90 expression in COPD, and in some assays, oxidant stress can impair GR?
Gene_expression (expression) of Hsp90 associated with stress and chronic obstructive pulmonary disease
5) Confidence 0.16 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 1.14 Pain Relevance 0.11
translocation contributes to reduced GC responsiveness in some diseases, such as in a subset of patients with multiple sclerosis where an elevation of expression of heat shock protein 90 (Hsp90) results in increased sequestration of GR?
Gene_expression (expression) of Hsp90 associated with multiple sclerosis, shock and disease
6) Confidence 0.12 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 1.09 Pain Relevance 0.12
secretion was reduced in the presence of the HSP-90 inhibitor geldanamycin D (Fig. 1B).
Gene_expression (presence) of HSP-90
7) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.05 Pain Relevance 0.08

General Comments

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