INT73982

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2011
Negated 2
Speculated 9
Reported most in Abstract
Documents 141
Total Number 179
Disease Relevance 119.43
Pain Relevance 32.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
liver 16
macrophages 7
spinal cord 5
kidney 3
lung 3
Hmox1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 536 100.00 Very High Very High Very High
Spinal cord 90 100.00 Very High Very High Very High
ischemia 412 99.92 Very High Very High Very High
Inflammation 2327 99.82 Very High Very High Very High
qutenza 25 99.82 Very High Very High Very High
Morphine 45 99.80 Very High Very High Very High
Glutamate 29 99.72 Very High Very High Very High
withdrawal 204 99.70 Very High Very High Very High
Antinociceptive 39 99.68 Very High Very High Very High
Paracetamol 68 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1192 100.00 Very High Very High Very High
Targeted Disruption 167 100.00 Very High Very High Very High
Shock 161 100.00 Very High Very High Very High
Porphyria 6 100.00 Very High Very High Very High
Apoptosis 1158 99.96 Very High Very High Very High
Cv General 4 Under Development 137 99.92 Very High Very High Very High
Injury 2297 99.88 Very High Very High Very High
Infection 676 99.84 Very High Very High Very High
INFLAMMATION 2698 99.82 Very High Very High Very High
Multiple Sclerosis 237 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Homozygous HO-1 Tg mice that overexpress HO-1 under the control of the neuron-specific enolase promoter (characterized previously) were used.
Gene_expression (overexpress) of HO-1 in neuron associated with targeted disruption
1) Confidence 0.78 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10037492 Disease Relevance 1.49 Pain Relevance 0.22
Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice.
Gene_expression (Overexpression) of heme oxygenase-1 in middle cerebral artery associated with targeted disruption and middle cerebral artery infarction
2) Confidence 0.78 Published 1999 Journal J. Neurochem. Section Title Doc Link 10037492 Disease Relevance 1.36 Pain Relevance 0.18
The purpose of this study was to investigate, using transgenic (Tg) mice, whether overexpression of HO-1 in the brain augments or attenuates cellular injury caused by ischemic stroke.
Gene_expression (overexpression) of HO-1 in brain associated with targeted disruption, stroke and injury
3) Confidence 0.78 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10037492 Disease Relevance 1.27 Pain Relevance 0.20
Morphine promoted expression of HO-1 in murine macrophages.
Gene_expression (expression) of HO-1 in macrophages associated with morphine
4) Confidence 0.77 Published 2003 Journal J. Infect. Dis. Section Abstract Doc Link 12508145 Disease Relevance 0.29 Pain Relevance 0.37
Previous results from our laboratory demonstrated that HO-1 overexpression has an antinociceptive effect in the formalin test.
Gene_expression (overexpression) of HO-1 associated with antinociceptive
5) Confidence 0.76 Published 2009 Journal Pain Section Abstract Doc Link 19660867 Disease Relevance 0.25 Pain Relevance 0.33
Western blot analysis revealed that epibatidine treatment increased by 2-fold HO-1 expression in the paw; this effect was lost in knockout mice for nuclear factor-erythroid 2-related factor 2 (Nrf2) and was accompanied by the loss of its antinociceptive effect.
Gene_expression (expression) of HO-1 in paw associated with targeted disruption and antinociceptive
6) Confidence 0.76 Published 2009 Journal Pain Section Abstract Doc Link 19660867 Disease Relevance 0.33 Pain Relevance 0.33
So, the aim of this study was to investigate the effect of HO-1 overexpression induced by epibatidine in nociception elicited by formalin injection in the mice hindpaw.
Gene_expression (overexpression) of HO-1 associated with nociception
7) Confidence 0.76 Published 2009 Journal Pain Section Abstract Doc Link 19660867 Disease Relevance 0.33 Pain Relevance 0.31
CoPP-induced HO-1 expression in Nrf2 knockout mice was lost and correlated with the loss of antinociceptive effects.
Gene_expression (expression) of HO-1 associated with targeted disruption and antinociceptive
8) Confidence 0.75 Published 2008 Journal Pain Section Abstract Doc Link 17964723 Disease Relevance 0.57 Pain Relevance 0.36
In conclusion, Nrf2-mediated HO-1 expression induced an antinociceptive effect at peripheral sites.
Gene_expression (expression) of HO-1 associated with antinociceptive
9) Confidence 0.75 Published 2008 Journal Pain Section Abstract Doc Link 17964723 Disease Relevance 0.49 Pain Relevance 0.39
Western blot analysis also revealed that CoPP treatment induced a similar 20-fold increase in HO-1 expression in the paw; this effect was attenuated in knockout mice for Nrf2.
Gene_expression (expression) of HO-1 in paw associated with targeted disruption
10) Confidence 0.75 Published 2008 Journal Pain Section Abstract Doc Link 17964723 Disease Relevance 0.55 Pain Relevance 0.23
In this regard, HO-1 overexpression can be achieved by either exogenously administration of HO-1 or enhancement of endogenous HO-1.
Gene_expression (overexpression) of HO-1
11) Confidence 0.74 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.67 Pain Relevance 0
Although the mechanisms underlying the protective actions of IPC have not been fully elucidated, recent evidence has suggested that the protective effects of ischemic preconditioning are attributable to expression of HO-1 [78, 79].
Gene_expression (expression) of HO-1
12) Confidence 0.74 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 1.19 Pain Relevance 0.21
Whole body hyperthermia to a core temperature of 42–43°C for 15 min significantly induced the production of heat shock protein-70 (HSP70) and HO-1 in intestinal mucosa and significantly reduced I/R-induced mucosal injury.
Gene_expression (production) of HO-1 in body associated with injury, shock and fever
13) Confidence 0.74 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 1.54 Pain Relevance 0.18
HO-2 is for the most part a constitutively synthesized protein existing in the brain and testis [8, 10].
Gene_expression (synthesized) of HO in testis
14) Confidence 0.74 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.93 Pain Relevance 0.05
Attuwaybi et al. showed that treatment with Hemin (50 µmol/kg, subcutaneously) 2 hours prior to warm I/R injury resulted in increased HO-1 protein expression, reduced mucosal injury, decreased myeloperoxidase (MPO) activity, and improved intestinal transit following gut I/R [68].
Gene_expression (expression) of HO-1 protein in gut associated with injury and urological neuroanatomy
15) Confidence 0.74 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.85 Pain Relevance 0
The combination of zinc protoporphyrin (ZnPP, an HO-1 inhibitor) with hyperthermia extinguished the protective effects of hyperthermia on I/R injury, suggesting that the protective effects of hyperthermia are mediated by HO-1 expression [80].
Gene_expression (expression) of HO-1 associated with injury and fever
16) Confidence 0.74 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 1.49 Pain Relevance 0.16
Interestingly, AC markedly upregulated hepatic HO-1 expression in CCl4-treated mice, which might provide anti-oxidative activity in the liver.
Gene_expression (expression) of HO-1 in liver
17) Confidence 0.71 Published 2009 Journal Food Chem. Toxicol. Section Abstract Doc Link 18984026 Disease Relevance 0.45 Pain Relevance 0.09
However, APAP caused more exaggerated liver injury in CXCR2-deficient mice with reduced macrophage infiltration and HO-1 gene expression, compared with neutropenic WT mice.
Gene_expression (expression) of HO-1 gene in macrophage associated with paracetamol and injury
18) Confidence 0.69 Published 2006 Journal Eur. J. Immunol. Section Abstract Doc Link 16552707 Disease Relevance 0.63 Pain Relevance 0.98
Moreover, neutrophils expressed iNOS, which is presumed to be an aggravating molecule for APAP-induced liver injury, while HO-1 was mainly expressed by macrophages.
Gene_expression (expressed) of HO-1 in liver associated with paracetamol and injury
19) Confidence 0.69 Published 2006 Journal Eur. J. Immunol. Section Abstract Doc Link 16552707 Disease Relevance 0.62 Pain Relevance 0.89
Homozygous HO-1 Tg mice that overexpress HO-1 under the control of the neuron-specific enolase promoter (characterized previously) were used.
Gene_expression (overexpress) of HO-1 in neuron associated with targeted disruption
20) Confidence 0.68 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10037492 Disease Relevance 1.49 Pain Relevance 0.22

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