INT73983

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Context Info
Confidence 0.43
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.08
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90aa1) protein folding (Hsp90aa1) cytosol (Hsp90aa1)
ATPase activity (Hsp90aa1) intracellular (Hsp90aa1) response to stress (Hsp90aa1)
Anatomy Link Frequency
cartilage 1
Hsp90aa1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 5 50.00 Quite Low
Osteoarthritis 4 50.00 Quite Low
Calcium channel 7 9.28 Low Low
Central nervous system 7 5.00 Very Low Very Low Very Low
TRP channel 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 5 76.00 Quite High
Lysosomal Storage Diseases 24 50.00 Quite Low
Shock 2 50.00 Quite Low
Gauchers Disease 11 5.00 Very Low Very Low Very Low
Mucopolysaccharidoses 11 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Neuropathic Pain 9 5.00 Very Low Very Low Very Low
Lysosome Storage Disease 6 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The mRNA levels of HSP47, HSP70, HSP86, IL-6, and IFN-gamma were up-regulated in the cartilage of C57 black mice, whereas, the level of expression of HSP32, HSP60, HSP84 and IL-1 beta remained unchanged.
Transcription (levels) of HSP86 in cartilage
1) Confidence 0.43 Published 1997 Journal Osteoarthr. Cartil. Section Body Doc Link 9497939 Disease Relevance 0.08 Pain Relevance 0
The mRNA expression levels of BiP, Hsp40, and Hsp90 were increased up to 1.8-fold, 1.8-fold, and 1.9-fold, respectively, after a 7-d treatment with diltiazem, whereas the mRNA expression levels of Hsp70, GRP94, calnexin, and calreticulin were not changed significantly.
Transcription (expression) of Hsp90
2) Confidence 0.18 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0

General Comments

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