INT73984

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Context Info
Confidence 0.35
First Reported 1997
Last Reported 2004
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 5.92
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Serpinh1) endoplasmic reticulum (Serpinh1) protein maturation (Serpinh1)
response to stress (Serpinh1) cytoplasm (Serpinh1)
Anatomy Link Frequency
cornea 2
eye 1
lens epithelium 1
cartilage 1
lens 1
Serpinh1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 24 71.60 Quite High
cytokine 5 50.00 Quite Low
Osteoarthritis 4 50.00 Quite Low
Inflammation 19 38.24 Quite Low
anesthesia 18 5.00 Very Low Very Low Very Low
ketamine 12 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cataract 120 98.92 Very High Very High Very High
Corneal Neovascularization 6 97.16 Very High Very High Very High
Wound Healing 72 96.12 Very High Very High Very High
Hyphema 6 95.12 Very High Very High Very High
Targeted Disruption 84 93.32 High High
Stress 91 84.60 Quite High
Shock 92 80.40 Quite High
Osteoarthritis 5 75.60 Quite High
Injury 54 68.28 Quite High
Corneal Opacity 30 64.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The mRNA levels of HSP47, HSP70, HSP86, IL-6, and IFN-gamma were up-regulated in the cartilage of C57 black mice, whereas, the level of expression of HSP32, HSP60, HSP84 and IL-1 beta remained unchanged.
Positive_regulation (up-regulated) of HSP47 in cartilage
1) Confidence 0.35 Published 1997 Journal Osteoarthr. Cartil. Section Body Doc Link 9497939 Disease Relevance 0.08 Pain Relevance 0
The maximal induction of Hsp 47 occurred at 3 hr after preconditioning in Group H and 24 hr in Group C as observed by Western blot (Fig. 4, Table 7).
Positive_regulation (induction) of Hsp 47
2) Confidence 0.18 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.97 Pain Relevance 0
In addition, induced Hsp 47 in the lens epithelium showed evidence of protection against cataract formation.
Positive_regulation (induced) of Hsp 47 in lens epithelium associated with cataract
3) Confidence 0.18 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 1.18 Pain Relevance 0.03
Our evidence showed that Hsp 47 induced in the cornea and lens may confer increased stability and resistance against excimer laser damage, thus it would be of further interest to study its role in the eye.
Positive_regulation (induced) of Hsp 47 in eye
4) Confidence 0.18 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.37 Pain Relevance 0
In the corneas of Group N there was no Hsp 47 induction.
Neg (no) Positive_regulation (induction) of Hsp 47 in corneas
5) Confidence 0.12 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 0.74 Pain Relevance 0
In light of these facts, the increased levels of Hsp 70 and Hsp 47 appeared to be major factors in the protection of the cornea and lens against lethal thermal damage, as well as played an important role in rapid wound healing, and decreased corneal and lens opacity after excimer laser ablation.
Positive_regulation (increased) of Hsp 47 in lens associated with wound healing and cataract
6) Confidence 0.10 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 1.29 Pain Relevance 0.04
In light of these facts, the increased levels of Hsp 70 and Hsp 47 appeared to be major factors in the protection of the cornea and lens against lethal thermal damage, as well as played an important role in rapid wound healing, and decreased corneal and lens opacity after excimer laser ablation.
Positive_regulation (increased) of Hsp 47 in cornea associated with wound healing and cataract
7) Confidence 0.03 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816848 Disease Relevance 1.29 Pain Relevance 0.04

General Comments

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