INT7399

Context Info Confidence 0.59 First Reported 1992 Last Reported 1999 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 0.35 Pain Relevance 1.70

plasma membrane (Grpr) signal transducer activity (Grpr)

Anatomy Link Frequency cholinergic neurons 1 nerve 1 neurons 1 uterine 1 Grpr (Rattus norvegicus)

Pain Link Frequency Relevance Heat Enkephalin 2 100.00 substance P 1 99.94 Dismenorea 2 95.72 antagonist 7 95.64 Somatostatin 14 93.44 tetrodotoxin 6 83.88 agonist 4 83.36 Neuropeptide 2 81.68

Disease Link Frequency Relevance Heat Bordatella Infection 1 98.36 Dysmenorrhea 2 95.72 Carcinoma 1 85.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Substance P-, bombesin- and enkephalin-like immunoreactivity was increased in local ganglionic cells and glandular nerve fibres.

Positive_regulation (increased) of bombesin in nerve associated with enkephalin and substance p

1) Confidence 0.59 Published 1999 Journal Acta Oncol Section Abstract Doc Link 10665767 Disease Relevance 0.09 Pain Relevance 0.22

The results demonstrate that rat myometrium expresses functional GRP-preferring Bn receptors whose activation stimulates the phospholipase C pathway, pertussis toxin-insensitive event that contributes to Bn-mediated uterine contractions.

Positive_regulation (activation) of GRP-preferring in uterine associated with bordatella infection and dismenorea

2) Confidence 0.41 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8279518 Disease Relevance 0.19 Pain Relevance 0.15

Peptone stimulates gastrin secretion from the stomach by activating bombesin/GRP and cholinergic neurons.

Positive_regulation (activating) of bombesin in cholinergic neurons

3) Confidence 0.12 Published 1992 Journal Am. J. Physiol. Section Title Doc Link 1348906 Disease Relevance 0 Pain Relevance 0.53

The results indicate that peptone stimulates gastrin secretion by activating stimulatory cholinergic and bombesin/GRP neurons.

Positive_regulation (activating) of bombesin in neurons

4) Confidence 0.12 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1348906 Disease Relevance 0 Pain Relevance 0.61

The removal of extracellular Ca2+ or the addition of nifedipine inhibited (35%) InsP production due to bombesin and ET-1.

Positive_regulation (due) of bombesin

5) Confidence 0.02 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215683 Disease Relevance 0.07 Pain Relevance 0.18

General Comments

This test has worked.