INT73990

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1998
Last Reported 2010
Negated 6
Speculated 0
Reported most in Abstract
Documents 19
Total Number 23
Disease Relevance 13.94
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hspa1b) molecular_function (Hspa1b) cellular_component (Hspa1b)
cytoplasm (Hspa1b)
Anatomy Link Frequency
SK-MEL-3 2
muscles 2
skeletal muscle 2
CLP 2
skin 2
Hspa1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 289 99.48 Very High Very High Very High
aspirin 12 99.34 Very High Very High Very High
Inflammation 21 97.30 Very High Very High Very High
ischemia 155 94.40 High High
anesthesia 16 92.04 High High
cytokine 11 90.92 High High
Cholecystokinin 3 88.60 High High
halothane 3 83.60 Quite High
withdrawal 1 76.48 Quite High
cINOD 4 74.36 Quite High
Disease Link Frequency Relevance Heat
Shock 106 100.00 Very High Very High Very High
Pancreatitis 15 99.90 Very High Very High Very High
Fever 51 99.86 Very High Very High Very High
Sepsis 10 99.78 Very High Very High Very High
Cancer 200 99.68 Very High Very High Very High
Body Weight 25 99.40 Very High Very High Very High
Skin Cancer 80 99.24 Very High Very High Very High
Stress 92 98.56 Very High Very High Very High
INFLAMMATION 26 97.30 Very High Very High Very High
Cv Unclassified Under Development 145 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results show that both early (9 hrs post-CLP) and late (18 hrs post-CLP) sepsis failed to increase the synthesis of Hsp72.
Neg (failed) Positive_regulation (increase) of Gene_expression (synthesis) of Hsp72 in CLP associated with sepsis
1) Confidence 0.70 Published 1998 Journal Kaohsiung J. Med. Sci. Section Abstract Doc Link 9838761 Disease Relevance 1.25 Pain Relevance 0.12
Long-term aspirin administration resulted in development of resistance to aspirin-induced mucosal damage, and the increase of HSP72 expression correlated with mucosal resistance to aspirin.
Positive_regulation (increase) of Gene_expression (expression) of HSP72 associated with aspirin
2) Confidence 0.69 Published 1999 Journal Dig. Dis. Sci. Section Abstract Doc Link 10489926 Disease Relevance 0.24 Pain Relevance 0.48
This study tested the requirement for hsp72 expression in a gerbil tolerance model in which postischemic temperature was varied to modulate the level of hsp72 induction.
Positive_regulation (requirement) of Gene_expression (expression) of hsp72 associated with tolerance
3) Confidence 0.64 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11078935 Disease Relevance 0.49 Pain Relevance 0.33
These experiments tested the hypothesis that thermal stress and mechanical load, concomitant with simulated exercise, provide independent stimuli for HSF1 activation and ensuing cardiac HSP72 gene expression.
Positive_regulation (activation) of Gene_expression (expression) of HSP72 gene associated with stress
4) Confidence 0.47 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16990482 Disease Relevance 0.47 Pain Relevance 0.08
These experiments tested the hypothesis that thermal stress and mechanical load, concomitant with simulated exercise, provide independent stimuli for HSF1 activation and ensuing cardiac HSP72 gene expression.
Neg (independent) Positive_regulation (stimuli) of Gene_expression (expression) of HSP72 gene associated with stress
5) Confidence 0.47 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16990482 Disease Relevance 0.47 Pain Relevance 0.08
These experiments tested the hypothesis that thermal stress and mechanical load, concomitant with simulated exercise, provide independent stimuli for HSF1 activation and ensuing cardiac HSP72 gene expression.
Positive_regulation (ensuing) of Gene_expression (expression) of HSP72 gene associated with stress
6) Confidence 0.47 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16990482 Disease Relevance 0.47 Pain Relevance 0.08
Hyperthermic preconditioning induces strong and long lasting HO-1/HSP32, HSP72, and HSP90 expression in rat kidneys.
Positive_regulation (induces) of Gene_expression (expression) of HSP72
7) Confidence 0.47 Published 2001 Journal Transpl. Int. Section Abstract Doc Link 11793032 Disease Relevance 0.61 Pain Relevance 0.03
Moreover, heat shock strongly induced renal HSP72 and HSP32/HO-1, and to a lesser extent HSP90, expression.
Positive_regulation (induced) of Gene_expression (expression) of HSP72 associated with shock
8) Confidence 0.47 Published 2001 Journal Transpl. Int. Section Abstract Doc Link 11793032 Disease Relevance 1.02 Pain Relevance 0.19
However, the locally and systemically heated rats demonstrated a marked improvement of skin survival, which correlated with increased skin levels of HSP72.
Positive_regulation (increased) of Gene_expression (levels) of HSP72 in skin
9) Confidence 0.46 Published 1998 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 9500396 Disease Relevance 0.21 Pain Relevance 0.08
The dose-response (5-40 mg/kg) and time-course (6-72 h) curves of methylprednisolone on pancreatic HSP60 and HSP72 synthesis were evaluated following methylprednisolone treatment.
Positive_regulation (pancreatic) of Gene_expression (synthesis) of HSP72
10) Confidence 0.46 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.57 Pain Relevance 0.20
The findings suggest that the anti-inflammatory effect of large doses of methylprednisolone in secretagogue-induced pancreatitis occurs downstream of NF-kappaB DNA binding, and that increased pancreatic HSP72 synthesis may play a role in the protective effect of the drug.
Positive_regulation (increased) of Gene_expression (synthesis) of HSP72 associated with inflammation and pancreatitis
11) Confidence 0.46 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.80 Pain Relevance 0.13
The pancreatitis was induced near the peak level of HSP72 synthesis (2 x 30 mg/kg body weight [b.w.] methylprednisolone i.m. at an interval of 12 h, followed by a 12-h recovery period after the second injection of methylprednisolone) by administering 2 x 100 microg/kg CCK subcutaneously at an interval of 1 h.
Positive_regulation (induced) of Gene_expression (synthesis) of HSP72 in body associated with body weight and pancreatitis
12) Confidence 0.46 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.63 Pain Relevance 0.18
These results indicate that, within the limits of experimental detection, hsp72 expression is not required for induction of ischemic tolerance.
Neg (not) Positive_regulation (required) of Gene_expression (expression) of hsp72 associated with tolerance
13) Confidence 0.46 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11078935 Disease Relevance 0.40 Pain Relevance 0.32
The expressions of heat shock protein 72 (HSP72) and calcineurin in both muscles were also increased within 1 and 7 days following heat-stress, respectively.
Positive_regulation (increased) of Gene_expression (expressions) of HSP72 in muscles associated with stress and shock
14) Confidence 0.45 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15883017 Disease Relevance 0.81 Pain Relevance 0.09
In melanoma cells not only a chemically and heat-induced expression of HSP (HSP72) has been demonstrated [31–34], but also a constitutive overexpression that was independent of stress (HSP27, HSP72, HSP90), as was the case in the SK-MEL-3 tumor.
Positive_regulation (induced) of Gene_expression (expression) of HSP72 in SK-MEL-3 associated with stress, cancer and skin cancer
15) Confidence 0.43 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.91 Pain Relevance 0
The administration of vinblastine under normothermic conditions (group II) was associated with an approximately 2.5-fold increase of HSP72 production, which dropped to a 1.5-fold rate of expression after 90 minutes. 5 hours postoperatively (60-minute perfusion time), the level of the untreated tumor was reached again.
Positive_regulation (increase) of Gene_expression (production) of HSP72 associated with cancer
16) Confidence 0.43 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.66 Pain Relevance 0
Hyperthermia alone caused a delayed increase of HSP72 expression by factor 1.5, which was kept even for 5 hours after the perfusion had been terminated (group III).
Positive_regulation (caused) of Gene_expression (expression) of HSP72 associated with fever
17) Confidence 0.43 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.77 Pain Relevance 0
In this study, we used similar type of supervised strength and power-type exercise than Gjovaag et al., and it may be one reason why our exercise program did not increase the expression of the HSP72.
Neg (not) Positive_regulation (increase) of Gene_expression (expression) of HSP72
18) Confidence 0.38 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.07 Pain Relevance 0
Neither 3, nor 8 min of IPC induced sufficient synthesis of Hsp72.
Neg (Neither) Positive_regulation (induced) of Gene_expression (synthesis) of Hsp72
19) Confidence 0.30 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2830184 Disease Relevance 0.89 Pain Relevance 0.59
The increase of HSP72 expression in the tumor tissue during hyperthermic temperatures was clearly evident, but with a delayed maximum for hyperthermia alone (60 minutes) in comparison with the combination of hyperthermia and vinblastine (30 minutes).
Positive_regulation (increase) of Gene_expression (expression) of HSP72 associated with cancer and fever
20) Confidence 0.29 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 1.03 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox