INT73991

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 11.40
Pain Relevance 3.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hspa1b) molecular_function (Hspa1b) cellular_component (Hspa1b)
cytoplasm (Hspa1b)
Anatomy Link Frequency
heart 3
liver 1
pancreas 1
neurons 1
skin 1
Hspa1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 84 99.20 Very High Very High Very High
fibrosis 6 99.08 Very High Very High Very High
ischemia 22 98.84 Very High Very High Very High
aspirin 11 95.92 Very High Very High Very High
adenocard 2 94.84 High High
halothane 3 92.72 High High
anesthesia 12 91.92 High High
Cholecystokinin 3 88.60 High High
cytokine 16 87.28 High High
cINOD 4 80.56 Quite High
Disease Link Frequency Relevance Heat
Shock 68 100.00 Very High Very High Very High
Stress 68 100.00 Very High Very High Very High
Fever 69 99.58 Very High Very High Very High
Fibrosis 6 99.08 Very High Very High Very High
Cv Unclassified Under Development 20 98.84 Very High Very High Very High
Reperfusion Injury 7 96.52 Very High Very High Very High
Disorders Of Creatine Metabolism 6 92.56 High High
Pancreatitis 15 92.48 High High
Injury 2 90.28 High High
Hyperglycemia 4 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical study showed an increase of HSP72 in the cytoplasm of mucosal surface cells.
Positive_regulation (increase) of HSP72
1) Confidence 0.69 Published 1999 Journal Dig. Dis. Sci. Section Abstract Doc Link 10489926 Disease Relevance 0.22 Pain Relevance 0.46
However, the locally and systemically heated rats demonstrated a marked improvement of skin survival, which correlated with increased skin levels of HSP72.
Positive_regulation (increased) of HSP72 in skin
2) Confidence 0.69 Published 1998 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 9500396 Disease Relevance 0.21 Pain Relevance 0.08
Heat shock preconditioning induces HSP72 in the rat liver with fibrosis and provides significantly increased tolerance of warm-ischemia reperfusion injury.
Positive_regulation (induces) of HSP72 in liver associated with fibrosis, ischemia, shock and tolerance
3) Confidence 0.68 Published 1998 Journal World J Surg Section Abstract Doc Link 9564289 Disease Relevance 1.10 Pain Relevance 0.45
Similarly, hyperthermia, independent of workload, resulted in significant increases in cardiac levels of HSP72 mRNA.
Positive_regulation (increases) of HSP72 associated with fever
4) Confidence 0.65 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16990482 Disease Relevance 0.45 Pain Relevance 0.08
We demonstrated that methylprednisolone specifically and dose-dependently induced HSP72 in the pancreas of rats, while it did not have a significant effect on HSP60 expression.
Positive_regulation (induced) of HSP72 in pancreas
5) Confidence 0.64 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.57 Pain Relevance 0.19
However, while 90% of hippocampi from NT animals showed detectable protection of CA1 neurons, less than half showed detectable hsp72 mRNA induction.
Positive_regulation (induction) of hsp72 in neurons
6) Confidence 0.64 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11078935 Disease Relevance 0.42 Pain Relevance 0.33
Brief ischemia induces tolerance to subsequent more severe insults, and induction of the 70 kDa heat shock/stress protein, hsp72, has been suggested to play a role.
Positive_regulation (induction) of hsp72 associated with stress, ischemia, shock and tolerance
7) Confidence 0.64 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11078935 Disease Relevance 0.45 Pain Relevance 0.30
This study tested the requirement for hsp72 expression in a gerbil tolerance model in which postischemic temperature was varied to modulate the level of hsp72 induction.
Positive_regulation (induction) of hsp72 associated with tolerance
8) Confidence 0.64 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11078935 Disease Relevance 0.48 Pain Relevance 0.34
Moreover, heat shock strongly induced renal HSP72 and HSP32/HO-1, and to a lesser extent HSP90, expression.
Positive_regulation (induced) of HSP72 associated with shock
9) Confidence 0.47 Published 2001 Journal Transpl. Int. Section Abstract Doc Link 11793032 Disease Relevance 1.00 Pain Relevance 0.18
HSP72 was induced in group HS at greater intensity than in group C.
Positive_regulation (induced) of HSP72
10) Confidence 0.46 Published 1998 Journal World J Surg Section Abstract Doc Link 9564289 Disease Relevance 1.00 Pain Relevance 0.44
Collectively, these data suggest that HSF1 activation and HSP72 gene transcriptional competence during simulated exercise are linked to elevated heart temperature and are not a direct function of increased cardiac workload.
Positive_regulation (activation) of HSP72 gene in heart
11) Confidence 0.44 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16990482 Disease Relevance 0.39 Pain Relevance 0.07
To elucidate the independent roles of increased temperature and cardiac workload in the exercise-mediated upregulation of left-ventricular HSP72, hearts from adult male Sprague-Dawley rats were randomly assigned to one of five simulated exercise conditions.
Positive_regulation (upregulation) of HSP72 in hearts
12) Confidence 0.38 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16990482 Disease Relevance 0.46 Pain Relevance 0.09
It has been demonstrated that the induction of HSP72 is closely associated with and regulated by 4-HNE protein adducts [60].
Positive_regulation (induction) of HSP72
13) Confidence 0.38 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.51 Pain Relevance 0.04
Confirmation experiments of haptoglobin, Hspa1b, Marcks, Gnat1, and Rcn did not reveal specific protein detection at the appropriate molecular weight with the antibodies tested.
Positive_regulation (experiments) of Hspa1b
14) Confidence 0.37 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.06 Pain Relevance 0
Most studies showing that exercise induced HSP72 [19], have used low force exercises with continuous activity.
Positive_regulation (induced) of HSP72
15) Confidence 0.33 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.20 Pain Relevance 0
In contrast to the cytostatic drug, hyperthermia causes a persistent induction of HSP72.
Positive_regulation (induction) of HSP72 associated with fever
16) Confidence 0.29 Published 2010 Journal Journal of Oncology Section Abstract Doc Link PMC2903950 Disease Relevance 0.84 Pain Relevance 0
The most widely studied HSP family is the 70-kDA family, which contains the constitutive HSP73 and inducible HSP72 forms.
Positive_regulation (inducible) of HSP72
17) Confidence 0.25 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.99 Pain Relevance 0.07
The dose-response (5-40 mg/kg) and time-course (6-72 h) curves of methylprednisolone on pancreatic HSP60 and HSP72 synthesis were evaluated following methylprednisolone treatment.
Positive_regulation (pancreatic) of HSP72
18) Confidence 0.20 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.56 Pain Relevance 0.20
The injections of CCK in the vehicle-pretreated group significantly elevated the levels of pancreatic HSP60 and HSP72 2-4 h after the second CCK injection.
Positive_regulation (elevated) of HSP72
19) Confidence 0.19 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.76 Pain Relevance 0.12
The HSP-72 levels increased in the lungs and the heart of heat-treated animals shortly after heat treatment.
Positive_regulation (increased) of HSP-72 in heart
20) Confidence 0.07 Published 2003 Journal Crit Care Section Body Doc Link PMC270667 Disease Relevance 0.71 Pain Relevance 0

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