INT73992

Context Info Confidence 0.78 First Reported 1998 Last Reported 2010 Negated 3 Speculated 2 Reported most in Abstract Documents 41 Total Number 52 Disease Relevance 37.26 Pain Relevance 6.88

nucleus (Hspa1b) molecular_function (Hspa1b) cellular_component (Hspa1b) cytoplasm (Hspa1b)

Anatomy Link Frequency skeletal muscle 6 muscle 3 puncture 2 SK-MEL-3 2 lymphocytes 2 Hspa1b (Rattus norvegicus)

Pain Link Frequency Relevance Heat colic 12 99.86 Pain 4 99.86 tolerance 672 99.48 aspirin 13 99.10 ischemia 306 98.74 Inflammation 48 96.88 anesthesia 35 96.60 imagery 27 96.40 halothane 5 92.24 cytokine 25 90.08

Disease Link Frequency Relevance Heat Shock 244 100.00 Sepsis 125 99.72 Cancer 438 99.68 Insulin Resistance 110 99.46 Stress 258 99.40 Body Weight 58 99.40 Fever 150 99.28 Pancreatitis 15 99.28 Skin Cancer 176 99.08 Diabetes Mellitus 280 98.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results show that both early (9 hrs post-CLP) and late (18 hrs post-CLP) sepsis failed to increase the synthesis of Hsp72.

Gene_expression (synthesis) of Hsp72 in CLP associated with sepsis

1) Confidence 0.78 Published 1998 Journal Kaohsiung J. Med. Sci. Section Abstract Doc Link 9838761 Disease Relevance 1.25 Pain Relevance 0.12

Applying a sufficient inducer to lymphocytes of late sepsis reversed the synthesis of Hsp72 from inactive state into an over-expressive situation in vitro.

Gene_expression (synthesis) of Hsp72 in lymphocytes associated with sepsis

2) Confidence 0.78 Published 1998 Journal Kaohsiung J. Med. Sci. Section Abstract Doc Link 9838761 Disease Relevance 1.18 Pain Relevance 0.11

Long-term aspirin administration resulted in development of resistance to aspirin-induced mucosal damage, and the increase of HSP72 expression correlated with mucosal resistance to aspirin.

Gene_expression (expression) of HSP72 associated with aspirin

3) Confidence 0.78 Published 1999 Journal Dig. Dis. Sci. Section Abstract Doc Link 10489926 Disease Relevance 0.23 Pain Relevance 0.47

The expression of myocardial heat shock protein 72 (HSP72) postexercise is initiated by the activation of heat shock transcription factor 1 (HSF1).

Gene_expression (expression) of HSP72 associated with shock

4) Confidence 0.73 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16990482 Disease Relevance 0.43 Pain Relevance 0

These experiments tested the hypothesis that thermal stress and mechanical load, concomitant with simulated exercise, provide independent stimuli for HSF1 activation and ensuing cardiac HSP72 gene expression.

Gene_expression (expression) of HSP72 gene associated with stress

5) Confidence 0.73 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16990482 Disease Relevance 0.47 Pain Relevance 0.08

HO-1/HSP32 and HSP72 were found to be expressed constitutively.

Gene_expression (expressed) of HSP72

6) Confidence 0.72 Published 2001 Journal Transpl. Int. Section Abstract Doc Link 11793032 Disease Relevance 1.09 Pain Relevance 0.21

Hyperthermic preconditioning induces strong and long lasting HO-1/HSP32, HSP72, and HSP90 expression in rat kidneys.

Gene_expression (expression) of HSP72

7) Confidence 0.72 Published 2001 Journal Transpl. Int. Section Abstract Doc Link 11793032 Disease Relevance 0.60 Pain Relevance 0.03

Moreover, heat shock strongly induced renal HSP72 and HSP32/HO-1, and to a lesser extent HSP90, expression.

Gene_expression (expression) of HSP72 associated with shock

8) Confidence 0.72 Published 2001 Journal Transpl. Int. Section Abstract Doc Link 11793032 Disease Relevance 0.97 Pain Relevance 0.18

The dose-response (5-40 mg/kg) and time-course (6-72 h) curves of methylprednisolone on pancreatic HSP60 and HSP72 synthesis were evaluated following methylprednisolone treatment.

Gene_expression (synthesis) of HSP72

9) Confidence 0.71 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.56 Pain Relevance 0.20

The pancreatitis was induced near the peak level of HSP72 synthesis (2 x 30 mg/kg body weight [b.w.] methylprednisolone i.m. at an interval of 12 h, followed by a 12-h recovery period after the second injection of methylprednisolone) by administering 2 x 100 microg/kg CCK subcutaneously at an interval of 1 h.

Gene_expression (synthesis) of HSP72 in body associated with body weight and pancreatitis

10) Confidence 0.71 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.63 Pain Relevance 0.17

This study tested the requirement for hsp72 expression in a gerbil tolerance model in which postischemic temperature was varied to modulate the level of hsp72 induction.

Gene_expression (expression) of hsp72 associated with tolerance

11) Confidence 0.71 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11078935 Disease Relevance 0.49 Pain Relevance 0.33

These results indicate that, within the limits of experimental detection, hsp72 expression is not required for induction of ischemic tolerance.

Gene_expression (expression) of hsp72 associated with tolerance

12) Confidence 0.71 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11078935 Disease Relevance 0.40 Pain Relevance 0.32

The expressions of heat shock protein 72 (HSP72) and calcineurin in both muscles were also increased within 1 and 7 days following heat-stress, respectively.

Gene_expression (expressions) of HSP72 in muscles associated with stress and shock

13) Confidence 0.69 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15883017 Disease Relevance 0.80 Pain Relevance 0.09

We investigated the influence of water-immersion stress or TRH administration on the expression of 60-kDa, 72-kDa, and 90-kDa heat-shock proteins (HSP60, HSP72, and HSP90, respectively) in rat small intestinal mucosa by Western blot and immunohistochemical analyses.

Gene_expression (expression) of HSP72 associated with stress and shock

14) Confidence 0.66 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753281 Disease Relevance 0.74 Pain Relevance 0.12

The findings suggest that the anti-inflammatory effect of large doses of methylprednisolone in secretagogue-induced pancreatitis occurs downstream of NF-kappaB DNA binding, and that increased pancreatic HSP72 synthesis may play a role in the protective effect of the drug.

Gene_expression (synthesis) of HSP72 associated with inflammation and pancreatitis

15) Confidence 0.62 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.80 Pain Relevance 0.13

Hsp72 mRNA expression was determined by in situ hybridization with a (35)S-labeled oligonucleotide probe at 3, 24 and 48 h.

Gene_expression (expression) of Hsp72

16) Confidence 0.62 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11078935 Disease Relevance 0.47 Pain Relevance 0.36

Hsp72 was detected by SDS-PAGE, Western blotting and immunostaining in the brain, heart, liver, kidney, lung, adrenal gland, muscle and lymphocytes.

Gene_expression (detected) of Hsp72 in heart

17) Confidence 0.60 Published 1998 Journal Kaohsiung J. Med. Sci. Section Abstract Doc Link 9838761 Disease Relevance 1.16 Pain Relevance 0.14

The present study was designed to investigate the expression of Hsp72 and the protective role of pre-induction of Hsps in the mortality during different phases of sepsis.

Spec (investigate) Gene_expression (expression) of Hsp72 associated with sepsis

18) Confidence 0.60 Published 1998 Journal Kaohsiung J. Med. Sci. Section Abstract Doc Link 9838761 Disease Relevance 0.83 Pain Relevance 0.12

There were no differences in nitroblue tetrazolium muscle staining times or muscle levels of HSP72 among the three groups.

Gene_expression (levels) of HSP72 in muscle

19) Confidence 0.60 Published 1998 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 9500396 Disease Relevance 0.17 Pain Relevance 0.08

However, the locally and systemically heated rats demonstrated a marked improvement of skin survival, which correlated with increased skin levels of HSP72.

Gene_expression (levels) of HSP72 in skin

20) Confidence 0.60 Published 1998 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 9500396 Disease Relevance 0.16 Pain Relevance 0.08

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