INT74015

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Context Info
Confidence 0.07
First Reported 1998
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.51
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (VHL, XRCC1) nucleoplasm (XRCC1) mitochondrion (VHL)
cell morphogenesis (VHL) endoplasmic reticulum (VHL) intracellular (XRCC1)
Anatomy Link Frequency
germline 1
VHL (Homo sapiens)
XRCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 1 94.64 High High
imagery 6 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 98 100.00 Very High Very High Very High
Disease 95 100.00 Very High Very High Very High
Renal Cancer 71 100.00 Very High Very High Very High
Cancer 70 99.96 Very High Very High Very High
Pheochromocytoma 16 99.60 Very High Very High Very High
Hemangioma 2 99.36 Very High Very High Very High
Hemangioblastoma 4 98.68 Very High Very High Very High
Nicotine Addiction 1 94.12 High High
Tuberous Sclerosis 1 91.00 High High
Renal Disease 1 86.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
or clear cell RCC, who have no detectable VHL disease-causing germline mutation; somatic mosaicism for a VHL gene mutation still needs to be considered in
VHL Spec (clear) Binding (mosaicism) of RCC in germline associated with disease
1) Confidence 0.07 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 1.19 Pain Relevance 0
Solid RCC of the clear cell type is associated with alterations in the VHL tumor suppressor gene and hereditary papillary RCC is associated with alterations of the c-met protooncogene.
VHL Spec (clear) Binding (associated) of RCC associated with cancer, syndrome and renal cancer
2) Confidence 0.06 Published 1998 Journal Toxicol Pathol Section Abstract Doc Link 9502393 Disease Relevance 1.92 Pain Relevance 0.09
This group of individuals would define a new VHL phenotype characterized by a low risk for both RCC and
VHL Binding (risk) of RCC
3) Confidence 0.06 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.40 Pain Relevance 0

General Comments

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