INT74016

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Context Info
Confidence 0.48
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 15.49
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VHL) mitochondrion (VHL) cell morphogenesis (VHL)
endoplasmic reticulum (VHL) nucleus (VHL) extracellular matrix organization (VHL)
Anatomy Link Frequency
proximal 2
RCA 2
nucleus 1
heart 1
VHL (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 1 92.80 High High
imagery 32 88.60 High High
Angina 3 88.16 High High
headache 5 82.92 Quite High
Morphine 4 69.20 Quite High
anesthesia 14 42.96 Quite Low
Pain 8 31.12 Quite Low
ischemia 34 18.72 Low Low
isoflurane 4 8.44 Low Low
Versed 4 5.44 Low Low
Disease Link Frequency Relevance Heat
Cancer 302 100.00 Very High Very High Very High
Syndrome 265 100.00 Very High Very High Very High
Pathologic Constriction 11 100.00 Very High Very High Very High
Disease 281 99.96 Very High Very High Very High
Renal Cancer 299 99.92 Very High Very High Very High
Renal Cell Carcinoma 62 99.92 Very High Very High Very High
Von Hippel-lindau Syndrome 21 99.72 Very High Very High Very High
Hypoxia 65 99.36 Very High Very High Very High
Pheochromocytoma 66 99.16 Very High Very High Very High
Aneurism 2 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
been shown to disrupt binding of pVHL to microtubules and abrogate the
pVHL Binding (binding) of
1) Confidence 0.48 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.58 Pain Relevance 0
/pVHL interaction [8] and the subsequent ubiquitinylation and degradation of HIF-1?
pVHL Binding (interaction) of
2) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.27 Pain Relevance 0
Mutations in the VHL gene either prevent its expression

(i.e., deletions, and frameshifts, nonsense mutations, splice site mutations) or lead to the

VHL Binding (Mutations) of
3) Confidence 0.37 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.69 Pain Relevance 0
Solid RCC of the clear cell type is associated with alterations in the VHL tumor suppressor gene and hereditary papillary RCC is associated with alterations of the c-met protooncogene.
VHL Binding (alterations) of associated with cancer, syndrome and renal cancer
4) Confidence 0.36 Published 1998 Journal Toxicol Pathol Section Abstract Doc Link 9502393 Disease Relevance 1.90 Pain Relevance 0.09
In patients with familial pheochromocytoma screening for gene mutations in the RET, VHL, SDHB and SDHD gene is recommended since different familial syndromes can be revealed.
VHL Binding (recommended) of associated with syndrome and pheochromocytoma
5) Confidence 0.35 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2169240 Disease Relevance 1.12 Pain Relevance 0
HBL in the sellar and suprasellar region are rare and may be sporadic or occur in association with VHL disease.
VHL Binding (association) of associated with disease
6) Confidence 0.35 Published 2005 Journal J Clin Neurosci Section Abstract Doc Link 15639422 Disease Relevance 0.62 Pain Relevance 0.29
These hydroxylated sites are recognized by the von-Hippel Lindau tumor suppressor (pVHL)[8], which ultimately leads to proteosomal degradation [5], [9]–[15].
pVHL Binding (recognized) of associated with cancer
7) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.34 Pain Relevance 0
undergoes a conformational change, is not recognized by pVHL, and enters the cell nucleus.
pVHL Binding (recognized) of in nucleus
8) Confidence 0.33 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727778 Disease Relevance 1.35 Pain Relevance 0
In well-oxygenated conditions, the VHL gene product pVHL recognizes HIF1?
pVHL Binding (recognizes) of associated with von hippel-lindau syndrome
9) Confidence 0.33 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727778 Disease Relevance 1.38 Pain Relevance 0
may also be used to evaluate individuals with a single VHL-associated tumor and
VHL Binding (individuals) of associated with cancer
10) Confidence 0.32 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.62 Pain Relevance 0
VHL occurs at a prevalence of
VHL Binding (occurs) of
11) Confidence 0.32 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 1.19 Pain Relevance 0
The pathogenesis of clear cell RCC is associated with loss of function of von Hippel-Lindau (VHL) gene and overproduction of the hypoxia-inducible factor (HIF).
VHL Spec (clear) Binding (associated) of associated with hypoxia and renal cell carcinoma
12) Confidence 0.32 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.97 Pain Relevance 0
On-pump coronary artery bypass grafting (CABG), ligation of RCA proximal and distal to the aneurysm, resection of the aneurysm was performed successfully.
RCA Binding (ligation) of in RCA associated with aneurism
13) Confidence 0.31 Published 2009 Journal Kyobu Geka Section Abstract Doc Link 19348221 Disease Relevance 0.62 Pain Relevance 0.09
Under hypoxic conditions, this interaction is disrupted secondary to loss of oxygen-dependent hydroxylation of HIF, leading to stabilization of the HIF transcription factors. 8 In the presence of a defective VHL gene and/or loss of protein function, the interaction between pVHL and HIF is disrupted despite the presence of adequate oxygen.
pVHL Binding (interaction) of associated with hypoxia
14) Confidence 0.29 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 1.13 Pain Relevance 0
The pathogenesis of clear cell RCC is associated with loss of function of von Hippel-Lindau (VHL) gene and overproduction of the hypoxia-inducible factor (HIF).
Hippel-Lindau Spec (clear) Binding (associated) of associated with hypoxia and renal cell carcinoma
15) Confidence 0.28 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.97 Pain Relevance 0
Its haploinsufficiency may facilitate the development of CC-RCC in association with VHL mutations, or otherwise lead to increased risk for other types of tumor.
VHL Binding (association) of associated with cancer and renal cancer
16) Confidence 0.25 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.48 Pain Relevance 0
Stenotic lesion of right coronary artery (RCA) in patients with right dominant coronary circulation has been known to be closely associated with right ventricular (RV) function (16-18), which has been suggested as an important prognostic factor of survival (19).
RCA Binding (associated) of in RCA
17) Confidence 0.08 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526513 Disease Relevance 0.39 Pain Relevance 0
The patients were randomized to RCA revascularization either with intracoronary shunt (Shunt Flo-Thru®, Synovis Surgical Innovations, St.
RCA Binding (randomized) of
18) Confidence 0.08 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526513 Disease Relevance 0.28 Pain Relevance 0.07
Hemodynamic variables including heart rate (HR), MAP, central venous pressure (CVP), mean pulmonary arterial pressure (MPAP), PCWP, cardiac index (CI), mixed venous oxygen saturation (SvO2), RV end diastolic volume index (RVEDVI), and RVEF were recorded 15 min after returning the heart to its natural position following completion of grafting at the left coronary arteries before RCA grafting (baseline, T1), 10 min after application of tissue stabilizer for distal anastomosis of the RCA (T2), and 15 min after completion of RCA grafting with the heart in its natural position (T3).
RCA Binding (completion) of in heart
19) Confidence 0.08 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526513 Disease Relevance 0.08 Pain Relevance 0
After approval of Institutional Review Board and patients' consent, 40 patients with either proximal or mid RCA stenosis scheduled for multivessel OPCAB including mid or distal RCA grafting were studied.
RCA Binding (proximal) of in proximal associated with pathologic constriction
20) Confidence 0.08 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526513 Disease Relevance 0.33 Pain Relevance 0

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