INT74018

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Context Info
Confidence 0.31
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 24.78
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (XRCC1) nucleus (XRCC1) intracellular (XRCC1)
Anatomy Link Frequency
pituitary 2
kidney 2
spinal 1
germline 1
skin 1
XRCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 6 98.20 Very High Very High Very High
agonist 6 97.12 Very High Very High Very High
Analgesic 8 95.00 High High
Pain 41 91.08 High High
tolerance 6 89.52 High High
headache 31 65.36 Quite High
imagery 47 57.84 Quite High
cytokine 9 52.12 Quite High
cva 13 40.40 Quite Low
palliative 3 38.36 Quite Low
Disease Link Frequency Relevance Heat
Renal Cancer 695 100.00 Very High Very High Very High
Cyst 130 100.00 Very High Very High Very High
Renal Cell Carcinoma 35 100.00 Very High Very High Very High
Precocious Puberty 38 99.98 Very High Very High Very High
Syndrome 122 99.96 Very High Very High Very High
Metastasis 113 99.56 Very High Very High Very High
Nicotine Addiction 16 99.56 Very High Very High Very High
Urinary Tract Cancer 4 99.32 Very High Very High Very High
Cancer 644 99.24 Very High Very High Very High
Generaliased Trisomy 3 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The data support SBRT as a safe and effective treatment modality that can be used to achieve good tumor control and palliation of pain associated with RCC spinal metastases.
RCC Binding (associated) of in spinal
1) Confidence 0.31 Published 2010 Journal Int. J. Radiat. Oncol. Biol. Phys. Section Body Doc Link 19632064 Disease Relevance 0.13 Pain Relevance 0
None of the above risk factor-RCC associations differed significantly between RCC cases with and without a FH of kidney cancer.
RCC Binding (associations) of in kidney associated with renal cancer
2) Confidence 0.30 Published 2001 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 11535554 Disease Relevance 1.73 Pain Relevance 0.10
A FH of urinary tract cancers other than kidney cancer was not associated with RCC risk (OR, 0.7; 95% CI, 0.3-1.7).
RCC Binding (associated) of in kidney associated with renal cancer and urinary tract cancer
3) Confidence 0.30 Published 2001 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 11535554 Disease Relevance 1.68 Pain Relevance 0.09
RCC symptom index
RCC Binding (index) of associated with renal cancer
4) Confidence 0.28 Published 2007 Journal Health Qual Life Outcomes Section Body Doc Link PMC1929060 Disease Relevance 1.77 Pain Relevance 0.41
Likewise, the protein coded for the XRCC1 gene participates in DNA single-strand breaks and in BER by its interaction with several of the enzymes involved in these processes.
XRCC1 Binding (interaction) of
5) Confidence 0.28 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0.15 Pain Relevance 0
XRCC1 has been shown to be localized to the nucleolus and to physically interact with hOGG1 (77–80).
XRCC1 Binding (interact) of
6) Confidence 0.27 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0.14 Pain Relevance 0
RCC compares to nonsmokers' after the fifth year of nonsmoking, but a meta-analysis
RCC Binding (compares) of associated with renal cancer
7) Confidence 0.21 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581742 Disease Relevance 1.29 Pain Relevance 0
They include carbonic anyhdrase IX, which is the RCC associated antigen G250 and is induced in many cancer types, hypoxia induced gene ADORA3, potentially oncogenic AXL gene which causes transformation when overexpressed in NIH 3T3 cells, and vitamin D receptor (VDR, up-regulated), which was found to be over-expressed in pancreatic cell lines (Albrechtsson et al. 2003) and is down-regulated by resveratrol compound (Shi et al. 2004) in RCC cell lines, which acts as a chemopreventive agent for RCC and other types of cancers.
RCC Binding (agent) of associated with hypoxia, cancer and renal cancer
8) Confidence 0.15 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.10 Pain Relevance 0
12), containing 43 previously associated with either RCC or other types of cancer.
RCC Binding (associated) of associated with cancer and renal cancer
9) Confidence 0.15 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 0.82 Pain Relevance 0
ATP6V1B1, EGLN3, SLC25A5, TUBB, ALDOA); others had never before been associated with RCC, but have been identified with other cancers (e.g.
RCC Binding (associated) of associated with cancer and renal cancer
10) Confidence 0.15 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 0.95 Pain Relevance 0
The main associations for RCC are summarized in (Figure 5 and Table 4).
RCC Binding (associations) of associated with renal cancer
11) Confidence 0.14 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.60 Pain Relevance 0
papillary RCC and germline mutations of MET commonly show trisomy of chromosome 7 when analyzed by cytogenetic studies and
RCC Binding (mutations) of in germline associated with generaliased trisomy
12) Confidence 0.06 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.40 Pain Relevance 0
associated with one or more of the various histological subtypes of RCC have
RCC Binding (associated) of
13) Confidence 0.06 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.51 Pain Relevance 0.10
Solid RCC of the clear cell type is associated with alterations in the VHL tumor suppressor gene and hereditary papillary RCC is associated with alterations of the c-met protooncogene.
RCC Spec (clear) Binding (associated) of associated with cancer, syndrome and renal cancer
14) Confidence 0.05 Published 1998 Journal Toxicol Pathol Section Abstract Doc Link 9502393 Disease Relevance 1.90 Pain Relevance 0.09
Solid RCC of the clear cell type is associated with alterations in the VHL tumor suppressor gene and hereditary papillary RCC is associated with alterations of the c-met protooncogene.
RCC Binding (associated) of associated with cancer, syndrome and renal cancer
15) Confidence 0.05 Published 1998 Journal Toxicol Pathol Section Abstract Doc Link 9502393 Disease Relevance 1.95 Pain Relevance 0.09
With the approval of a number of novel therapies for treatment of RCC, the next logical step is to combine them and assess their interaction.
RCC Binding (interaction) of associated with renal cancer
16) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721410 Disease Relevance 0.51 Pain Relevance 0.04
AVF0890s recruited 116 patients with metastatic RCC who were not optimal candidates for IL-2 therapy or had previously not responded to this therapy.
RCC Binding (recruited) of associated with renal cancer
17) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721410 Disease Relevance 1.08 Pain Relevance 0.07
A Japanese literature review reported 75 cases of RCC associated with skin metastasis.
RCC Binding (associated) of in skin associated with renal cell carcinoma and metastasis
18) Confidence 0.02 Published 2006 Journal Int Semin Surg Oncol Section Body Doc Link PMC1578574 Disease Relevance 2.14 Pain Relevance 0
It is assumed that the precocious puberty associated with RCC is caused by a different mechanism than that causing dysfunction of other pituitary hormones.
RCC Binding (associated) of in pituitary associated with precocious puberty and cyst
19) Confidence 0.01 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3004488 Disease Relevance 2.39 Pain Relevance 0.12
Karavitaki et al20) and Bader et al21) found corticotrophic pituitary adenoma in adult patients with an RCC accompanied by Cushing's syndrome; these patients showed considerable hypersecretory dysfunction associated with the RCC.
RCC Binding (associated) of in pituitary associated with syndrome, pituitary cancer and cyst
20) Confidence 0.01 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3004488 Disease Relevance 2.17 Pain Relevance 0.13

General Comments

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