INT74019

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Context Info
Confidence 0.35
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 23.61
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TSC1) embryo development (TSC1) protein complex (TSC1)
cytoplasm (TSC1)
Anatomy Link Frequency
brain 1
lung 1
TSC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 41 97.84 Very High Very High Very High
Analgesic 1 92.80 High High
Ventral tegmentum 8 83.60 Quite High
cytokine 1 80.88 Quite High
fibrosis 1 80.56 Quite High
Neuropathic pain 2 77.84 Quite High
Chronic pancreatitis 13 75.92 Quite High
peripheral neuropathy 1 69.52 Quite High
agonist 33 64.72 Quite High
midbrain 15 64.64 Quite High
Disease Link Frequency Relevance Heat
Cancer 1418 100.00 Very High Very High Very High
Syndrome 24 100.00 Very High Very High Very High
Pancreatic Ductal Carcinoma 4 99.28 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 99.24 Very High Very High Very High
Head & Neck Cancer 2 99.16 Very High Very High Very High
Renal Cancer 17 99.14 Very High Very High Very High
Immunotherapy Of Cancer 1 99.14 Very High Very High Very High
Cervical Cancer 6 99.04 Very High Very High Very High
Tuberous Sclerosis 27 98.88 Very High Very High Very High
Chordoma 131 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another hamartin binding protein has also been implicated in the regulation of the TSC tumour suppressor complex.
Regulation (regulation) of TSC associated with cancer
1) Confidence 0.35 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.45 Pain Relevance 0
The role in chordomagenesis of the Tuberous Sclerosis Complex (TSC) genes has been proved, but the extent of involvement of TSC1 and TSC2 oncosuppressors in chordoma remains to be assessed.
Regulation (involvement) of TSC1 associated with tuberous sclerosis and chordoma
2) Confidence 0.35 Published 2005 Journal Hered Cancer Clin Pract Section Abstract Doc Link PMC2837065 Disease Relevance 0.99 Pain Relevance 0
Tenofovir is currently only approved for use in HIV positive patients but has been to be effective for LAM resistant mutants and for those patients who have failed prior ADV and LAM.
Regulation (effective) of LAM associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.35 Published 2006 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC1459192 Disease Relevance 0.60 Pain Relevance 0
Unaffected parents who have had a child affected with TSC usually are given a low (1%) recurrence risk.
Regulation (affected) of TSC associated with recurrence
4) Confidence 0.22 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.33 Pain Relevance 0
Solid RCC of the clear cell type is associated with alterations in the VHL tumor suppressor gene and hereditary papillary RCC is associated with alterations of the c-met protooncogene.
Regulation (alterations) of tumor suppressor associated with cancer, syndrome and renal cancer
5) Confidence 0.11 Published 1998 Journal Toxicol Pathol Section Abstract Doc Link 9502393 Disease Relevance 1.96 Pain Relevance 0.09
Since little was known about the regulatory mechanisms of Pdcd4 in cancer, Asangani et al. sought to determine the role, if any, of miRNAs in the regulation of this tumor suppressor as well as their role in invasion and intravasation [62].
Regulation (regulation) of tumor suppressor associated with cancer
6) Confidence 0.07 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 1.02 Pain Relevance 0
Pdcd4, a novel tumor suppressor, is down regulated in various types of cancer, especially lung and colorectal, which is associated with poor patient prognosis.
Regulation (regulated) of tumor suppressor in lung associated with cancer
7) Confidence 0.07 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 1.13 Pain Relevance 0
It is also noteworthy that B-DIM treatment affected mostly oncogenic miRNAs while G2535 treatment affected both oncogenic miRNAs as well as tumor suppressor miRNAs, mostly members of the let-7 family, suggesting that these changes could reflect different mechanisms of action between these two anti-cancer agents.
Regulation (affected) of tumor suppressor associated with cancer
8) Confidence 0.07 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.34 Pain Relevance 0
Three markers – DIRAS3, MGMT, and HRAS – showed statistically significant hypermethylation in non-tumor tissue.
Regulation (hypermethylation) of non-tumor associated with cancer
9) Confidence 0.06 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2483990 Disease Relevance 0.88 Pain Relevance 0
BACKGROUND: Aberrant methylation of CpG islands is a common mechanism for the dysregulation of tumor suppressor genes in a variety of human malignancies.
Regulation (dysregulation) of tumor suppressor associated with cancer
10) Confidence 0.05 Published 2006 Journal J. Gastroenterol. Section Abstract Doc Link 16988769 Disease Relevance 0.52 Pain Relevance 0.08
Such a mechanism of action is of particular interest in the field of cancer treatment, considering the reactivation of silenced tumor suppressor genes as an important target at which aiming; indeed, it is currently believed that dysregulation of the epigenome plays a major role in cancer.
Regulation (target) of tumor suppressor associated with cancer and immunotherapy of cancer
11) Confidence 0.04 Published 2008 Journal Curr Cancer Drug Targets Section Abstract Doc Link 18537550 Disease Relevance 0.64 Pain Relevance 0.11
These results are in line with our observations in breast and cervical cancer patients that hydralazine and valproate can up-regulate a huge number of tumor suppressor genes.
Regulation (regulate) of tumor suppressor associated with cervical cancer and cancer
12) Confidence 0.03 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1796571 Disease Relevance 1.31 Pain Relevance 0
Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma

Background

Regulation (Alterations) of tumor suppressor associated with pancreatic ductal carcinoma and cancer
13) Confidence 0.03 Published 2005 Journal BMC Gastroenterol Section Title Doc Link PMC1185532 Disease Relevance 0.61 Pain Relevance 0
Cell cycle inhibitor and tumor suppressor gene p16 / MTS-1 has been reported to be altered in a variety of human tumors.
Regulation (altered) of tumor suppressor associated with cancer
14) Confidence 0.03 Published 2005 Journal BMC Gastroenterol Section Abstract Doc Link PMC1185532 Disease Relevance 0.53 Pain Relevance 0
Evidence of the involvement of such miRNAs, their implications to cancer through targeting proto oncogenes or tumor suppressor genes have been described in the following subsections.
Regulation (targeting) of tumor suppressor associated with cancer
15) Confidence 0.03 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.50 Pain Relevance 0
Oncogenic miRNAs are up-regulated in cancer and contribute to its pathology through various mechanisms such as targeting tumor suppressor genes.
Regulation (targeting) of tumor suppressor associated with cancer
16) Confidence 0.03 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.79 Pain Relevance 0
In PC346DCC, activation of VAV3 and TWIST1 oncogenes and down-regulation of DKK3 tumor suppressor constitutes a possible mechanism for bypassing the AR pathway.
Regulation (regulation) of tumor suppressor associated with cancer
17) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.96 Pain Relevance 0.04
Zhu et al. performed two-dimensional differentiation in-gel electrophoresis of tumors treated with anti-miR-21 and identified the tumor suppressor tropomyosin 1 as a potential miR-21 target.
Regulation (target) of tumor suppressor associated with cancer
18) Confidence 0.02 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.01 Pain Relevance 0
Several tumor suppressor genes were identified to be potential targets of miRNAs, including kinesin family member 1B isoform alpha, hypermethylated in cancer 2 and pleomorphic adenoma gene 1 [22].
Regulation (targets) of tumor suppressor associated with pleomorphic adenoma and cancer
19) Confidence 0.02 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.20 Pain Relevance 0
Since in cancer cell DNA methylation usually affects tumor suppressor genes which are genetically intact, their reactivation after demethylation completely restores their normal functions.
Regulation (affects) of tumor suppressor associated with cancer
20) Confidence 0.02 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.45 Pain Relevance 0

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