INT74020

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Context Info
Confidence 0.35
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 17.18
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (XRCC1) nucleus (XRCC1) intracellular (XRCC1)
Anatomy Link Frequency
right renal vein 1
Caki-1 1
XRCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 23 100.00 Very High Very High Very High
Spinal cord 1 99.52 Very High Very High Very High
cINOD 26 96.88 Very High Very High Very High
Analgesic 6 96.76 Very High Very High Very High
Pain 8 95.56 Very High Very High Very High
addiction 8 93.40 High High
COX-2 inhibitor 16 73.64 Quite High
aspirin 3 73.60 Quite High
cytokine 15 28.80 Quite Low
palliative 1 24.08 Low Low
Disease Link Frequency Relevance Heat
Renal Cancer 623 100.00 Very High Very High Very High
Carcinoma 73 100.00 Very High Very High Very High
Disease 195 99.20 Very High Very High Very High
INFLAMMATION 10 98.80 Very High Very High Very High
Cancer 590 98.72 Very High Very High Very High
Metastasis 82 97.12 Very High Very High Very High
Nicotine Addiction 11 96.24 Very High Very High Very High
Pain 6 95.56 Very High Very High Very High
Pheochromocytoma 26 94.44 High High
Toxicity 31 93.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interventions to reduce the prevalence of RCC have the potential to yield considerable economic benefits.


Negative_regulation (prevalence) of RCC
1) Confidence 0.35 Published 2007 Journal Urol. Oncol. Section Body Doc Link 17826652 Disease Relevance 0 Pain Relevance 0
In our case, preoperative imaging of the RCC before radical nephrectomy had not revealed any involvement of the inferior vena cava or the right renal vein.
Negative_regulation (imaging) of RCC in right renal vein associated with renal cancer and imagery
2) Confidence 0.30 Published 2008 Journal Cases J Section Body Doc Link PMC2562357 Disease Relevance 1.56 Pain Relevance 0.09
clinical factors related to the development of RCC have been established.
Negative_regulation (development) of RCC associated with renal cancer
3) Confidence 0.25 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581742 Disease Relevance 0.75 Pain Relevance 0
It is clear that the processes shown are all linked to energy generation in the cell and that most of these genes are suppressed in RCC.
Negative_regulation (suppressed) of RCC associated with renal cancer
4) Confidence 0.24 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.72 Pain Relevance 0.06
In accordance with that, it was shown that expression levels of OXPHOS genes were down-regulated in RCC (Simonnet et al. 2002; Meierhofer et al. 2004).
Negative_regulation (regulated) of RCC associated with renal cancer
5) Confidence 0.17 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.55 Pain Relevance 0.14
Chawla et al. showed RCC mean growth rate
Negative_regulation (showed) of RCC associated with carcinoma
6) Confidence 0.14 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2629071 Disease Relevance 2.04 Pain Relevance 0
ligands troglitazone and 15-d-PGJ2 induced the reduction of RCC cell line (Caki-1) viability in the range of 10–40 ?
Negative_regulation (reduction) of RCC in Caki-1 associated with renal cancer
7) Confidence 0.07 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994214 Disease Relevance 1.54 Pain Relevance 0.07
Hence, new molecular targets are needed for the prevention and treatment of RCC.
Negative_regulation (prevention) of RCC associated with renal cancer
8) Confidence 0.07 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994214 Disease Relevance 0.98 Pain Relevance 0.46
reported a reduced risk for RCC in individuals with a complete deletion of the VHL gene.
Negative_regulation (reduced) of RCC
9) Confidence 0.06 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.46 Pain Relevance 0
type 1 and type 2B mutations, which predispose to RCC, show complete loss of HIF1?
Negative_regulation (predispose) of RCC
10) Confidence 0.06 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.58 Pain Relevance 0
development of RCC [14].
Negative_regulation (development) of RCC
11) Confidence 0.06 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.63 Pain Relevance 0
Recently, several of the genetic targets for alterations involved in the development of human RCC have been identified.
Negative_regulation (development) of RCC associated with renal cancer
12) Confidence 0.06 Published 1998 Journal Toxicol Pathol Section Abstract Doc Link 9502393 Disease Relevance 1.77 Pain Relevance 0.10
Both, the RCC and the metastatic lesion were completely removed in February 2003.
Negative_regulation (removed) of RCC associated with renal cancer
13) Confidence 0.02 Published 2008 Journal Cases J Section Body Doc Link PMC2567305 Disease Relevance 1.37 Pain Relevance 0.15
Temsirolimus, the second mTOR inhibitor approved in advanced RCC, has also been combined with bevacizumab.
Negative_regulation (inhibitor) of RCC associated with renal cancer
14) Confidence 0.02 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 1.02 Pain Relevance 0
Thus, the relative expression of DPP4 (DPP IV transcriptome) and MME (NEP transcriptome) genes were found to be strongly decreased in ChRCC samples (DPP IV: ?
Negative_regulation (decreased) of ChRCC
15) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.52 Pain Relevance 0
Loss of activity was slight in CCRCC (twofold), whereas it drastically decreased in the ChRCC (sixteenfold) and, although in a lesser intensity, in the RO (sixfold).
Negative_regulation (decreased) of ChRCC
16) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.69 Pain Relevance 0

General Comments

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