INT74020

Context Info Confidence 0.35 First Reported 1998 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 16 Total Number 16 Disease Relevance 17.18 Pain Relevance 1.06

nucleoplasm (XRCC1) nucleus (XRCC1) intracellular (XRCC1)

Anatomy Link Frequency right renal vein 1 Caki-1 1 XRCC1 (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 23 100.00 Spinal cord 1 99.52 cINOD 26 96.88 Analgesic 6 96.76 Pain 8 95.56 addiction 8 93.40 COX-2 inhibitor 16 73.64 aspirin 3 73.60 cytokine 15 28.80 palliative 1 24.08

Disease Link Frequency Relevance Heat Renal Cancer 623 100.00 Carcinoma 73 100.00 Disease 195 99.20 INFLAMMATION 10 98.80 Cancer 590 98.72 Metastasis 82 97.12 Nicotine Addiction 11 96.24 Pain 6 95.56 Pheochromocytoma 26 94.44 Toxicity 31 93.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interventions to reduce the prevalence of RCC have the potential to yield considerable economic benefits.

Negative_regulation (prevalence) of RCC

1) Confidence 0.35 Published 2007 Journal Urol. Oncol. Section Body Doc Link 17826652 Disease Relevance 0 Pain Relevance 0

In our case, preoperative imaging of the RCC before radical nephrectomy had not revealed any involvement of the inferior vena cava or the right renal vein.

Negative_regulation (imaging) of RCC in right renal vein associated with renal cancer and imagery

2) Confidence 0.30 Published 2008 Journal Cases J Section Body Doc Link PMC2562357 Disease Relevance 1.56 Pain Relevance 0.09

clinical factors related to the development of RCC have been established.

Negative_regulation (development) of RCC associated with renal cancer

3) Confidence 0.25 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581742 Disease Relevance 0.75 Pain Relevance 0

It is clear that the processes shown are all linked to energy generation in the cell and that most of these genes are suppressed in RCC.

Negative_regulation (suppressed) of RCC associated with renal cancer

4) Confidence 0.24 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.72 Pain Relevance 0.06

In accordance with that, it was shown that expression levels of OXPHOS genes were down-regulated in RCC (Simonnet et al. 2002; Meierhofer et al. 2004).

Negative_regulation (regulated) of RCC associated with renal cancer

5) Confidence 0.17 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.55 Pain Relevance 0.14

Chawla et al. showed RCC mean growth rate

Negative_regulation (showed) of RCC associated with carcinoma

6) Confidence 0.14 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2629071 Disease Relevance 2.04 Pain Relevance 0

ligands troglitazone and 15-d-PGJ2 induced the reduction of RCC cell line (Caki-1) viability in the range of 10–40 ?

Negative_regulation (reduction) of RCC in Caki-1 associated with renal cancer

7) Confidence 0.07 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994214 Disease Relevance 1.54 Pain Relevance 0.07

Hence, new molecular targets are needed for the prevention and treatment of RCC.

Negative_regulation (prevention) of RCC associated with renal cancer

8) Confidence 0.07 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994214 Disease Relevance 0.98 Pain Relevance 0.46

reported a reduced risk for RCC in individuals with a complete deletion of the VHL gene.

Negative_regulation (reduced) of RCC

9) Confidence 0.06 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.46 Pain Relevance 0

type 1 and type 2B mutations, which predispose to RCC, show complete loss of HIF1?

Negative_regulation (predispose) of RCC

10) Confidence 0.06 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.58 Pain Relevance 0

development of RCC [14].

Negative_regulation (development) of RCC

11) Confidence 0.06 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.63 Pain Relevance 0

Recently, several of the genetic targets for alterations involved in the development of human RCC have been identified.

Negative_regulation (development) of RCC associated with renal cancer

12) Confidence 0.06 Published 1998 Journal Toxicol Pathol Section Abstract Doc Link 9502393 Disease Relevance 1.77 Pain Relevance 0.10

Both, the RCC and the metastatic lesion were completely removed in February 2003.

Negative_regulation (removed) of RCC associated with renal cancer

13) Confidence 0.02 Published 2008 Journal Cases J Section Body Doc Link PMC2567305 Disease Relevance 1.37 Pain Relevance 0.15

Temsirolimus, the second mTOR inhibitor approved in advanced RCC, has also been combined with bevacizumab.

Negative_regulation (inhibitor) of RCC associated with renal cancer

14) Confidence 0.02 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 1.02 Pain Relevance 0

Thus, the relative expression of DPP4 (DPP IV transcriptome) and MME (NEP transcriptome) genes were found to be strongly decreased in ChRCC samples (DPP IV: ?

Negative_regulation (decreased) of ChRCC

15) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.52 Pain Relevance 0

Loss of activity was slight in CCRCC (twofold), whereas it drastically decreased in the ChRCC (sixteenfold) and, although in a lesser intensity, in the RO (sixfold).

Negative_regulation (decreased) of ChRCC

16) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.69 Pain Relevance 0

General Comments

This test has worked.