INT74021

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Context Info
Confidence 0.44
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 16.91
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (XRCC1) nucleus (XRCC1) intracellular (XRCC1)
Anatomy Link Frequency
upper 4
uterine 1
XRCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 27 96.64 Very High Very High Very High
addiction 32 93.40 High High
Inflammation 2 83.96 Quite High
positron emission tomography 89 80.48 Quite High
imagery 157 80.00 Quite High
Pain 14 75.52 Quite High
Analgesic 5 71.16 Quite High
headache 1 62.52 Quite High
alcohol 3 44.00 Quite Low
palliative 1 34.44 Quite Low
Disease Link Frequency Relevance Heat
Cancer 1210 100.00 Very High Very High Very High
Renal Cancer 718 100.00 Very High Very High Very High
Carcinoma 77 100.00 Very High Very High Very High
Reprotox - General 1 57 99.66 Very High Very High Very High
Malignant Neoplastic Disease 37 99.36 Very High Very High Very High
Disease 180 98.96 Very High Very High Very High
Nasopharynx Cancer 145 98.84 Very High Very High Very High
Uterine Fibroids 3 97.04 Very High Very High Very High
Leiomyosarcoma 3 96.12 Very High Very High Very High
Metastasis 169 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The study material comprised 7 FH mutation-negative HLRCC patients and 12 patients affected with HLRCC-associated phenotypes, including papillary RCC, early-onset RCC, uterine leiomyomas, or uterine leiomyosarcoma.
Regulation (affected) of RCC in uterine associated with leiomyosarcoma and uterine fibroids
1) Confidence 0.44 Published 2008 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 18503824 Disease Relevance 0.95 Pain Relevance 0.08
On the other hand, the XRCC1 gene is important in DNA base excision repair.
Regulation (important) of XRCC1
2) Confidence 0.36 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.45 Pain Relevance 0.06
can affirm that respect RCC, like in other malignant diseases, ethiology, and
Regulation (affirm) of RCC associated with malignant neoplastic disease, renal cancer and disease
3) Confidence 0.26 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581742 Disease Relevance 1.72 Pain Relevance 0.06
Two big clusters of genes are revealed: down-regulated genes in RCC (upper half) and up-regulated in RCC (bottom half) with respect to the normal samples, together with subclusters within these groups.
Regulation (regulated) of RCC in upper associated with renal cancer
4) Confidence 0.25 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 0.27 Pain Relevance 0
Two big clusters of genes are revealed: down-regulated genes in RCC (upper half) and up-regulated in RCC (bottom half) with respect to the normal samples, together with subclusters within these groups.
Regulation (regulated) of RCC in upper associated with renal cancer
5) Confidence 0.25 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 0.27 Pain Relevance 0
In accordance with that, it was shown that expression levels of OXPHOS genes were down-regulated in RCC (Simonnet et al. 2002; Meierhofer et al. 2004).
Regulation (regulated) of RCC associated with renal cancer
6) Confidence 0.18 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.55 Pain Relevance 0.14
Interestingly, all markers involved in calcium signaling pathways are down-regulated in RCC.
Regulation (regulated) of RCC associated with renal cancer
7) Confidence 0.18 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 0.89 Pain Relevance 0.04
this variable is one of the most important prognosis factors for RCC, and it has also
Regulation (one) of RCC associated with carcinoma
8) Confidence 0.15 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2629071 Disease Relevance 1.24 Pain Relevance 0.08
Some of the genes were already shown to be important in RCC by additional studies other than listed in Table 5.
Regulation (important) of RCC associated with renal cancer
9) Confidence 0.11 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.10 Pain Relevance 0.03
NCOR2 gene (Table 4) suppresses tumor growth in prostate cancer cells but is up-regulated in RCC, and hence it is not included.
Regulation (regulated) of RCC associated with cancer, renal cancer and reprotox - general 1
10) Confidence 0.11 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.66 Pain Relevance 0
Two big clusters of genes are revealed: down-regulated genes in RCC (upper half) and up-regulated in RCC (bottom half) with respect to the normal samples, together with subclusters within these groups.
Regulation (regulated) of RCC in upper associated with renal cancer
11) Confidence 0.11 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 0.27 Pain Relevance 0
Two big clusters of genes are revealed: down-regulated genes in RCC (upper half) and up-regulated in RCC (bottom half) with respect to the normal samples, together with subclusters within these groups.
Regulation (regulated) of RCC in upper associated with renal cancer
12) Confidence 0.11 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 0.27 Pain Relevance 0
These data suggest that different variants of RCC have distinct molecular etiologies and that there are species-specific determinants that modulate the involvement of specific tumor suppressor genes in RCC.
Spec (determinants) Regulation (modulate) of RCC associated with cancer and renal cancer
13) Confidence 0.07 Published 1998 Journal Toxicol Pathol Section Abstract Doc Link 9502393 Disease Relevance 1.97 Pain Relevance 0.07
Its effect on advanced refractory RCC patients was demonstrated initially in a randomized phase II trial of patients with metastatic RCC.
Regulation (effect) of RCC associated with renal cancer
14) Confidence 0.02 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2527326 Disease Relevance 1.16 Pain Relevance 0
RCC are usually resistant to classical chemotherapeutic agents but there are several small case studies reporting on partial remissions of sarcomatoid RCC after doxorubicin-based chemotherapeutic protocols [3-7].
Regulation (resistant) of RCC associated with renal cancer
15) Confidence 0.01 Published 2008 Journal Cases J Section Body Doc Link PMC2567305 Disease Relevance 1.01 Pain Relevance 0.04
For decades, the treatment options for patients with metastatic renal cell cancer (mRCC) have been very limited, as RCC in general is not sensitive to chemotherapy.
Neg (not) Regulation (sensitive) of RCC associated with renal cancer
16) Confidence 0.00 Published 2010 Journal Target Oncol Section Body Doc Link PMC2929340 Disease Relevance 0.78 Pain Relevance 0.20
Besides inhibition of VEGF signaling, the mammalian target of rapamycin (mTOR) is another important therapeutic target in RCC, although its mechanisms of activation are not yet fully understood. mTOR may play a role in the development of RCC and is associated with elevated HIF activity [14]. mTOR inhibitors seem to down-regulate HIF activity primarily when the mTOR pathway is abnormally activated [15, 16].
Regulation (target) of RCC associated with renal cancer
17) Confidence 0.00 Published 2010 Journal Target Oncol Section Body Doc Link PMC2929340 Disease Relevance 0.35 Pain Relevance 0.08

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