INT74022

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.24
First Reported 1998
Last Reported 2009
Negated 1
Speculated 4
Reported most in Abstract
Documents 6
Total Number 10
Disease Relevance 5.73
Pain Relevance 3.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
peripheral nerve 3
spinal cord 1
Cpox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 55 100.00 Very High Very High Very High
cytokine 52 100.00 Very High Very High Very High
Spinal cord 6 100.00 Very High Very High Very High
agonist 5 100.00 Very High Very High Very High
cOX1 11 99.84 Very High Very High Very High
ischemia 4 99.60 Very High Very High Very High
Pain 20 97.72 Very High Very High Very High
Inflammatory response 11 97.36 Very High Very High Very High
antagonist 1 95.44 Very High Very High Very High
COX-2 inhibitor 5 94.24 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 86 100.00 Very High Very High Very High
Cancer 4 99.84 Very High Very High Very High
Nervous System Injury 14 99.60 Very High Very High Very High
Necrosis 13 99.60 Very High Very High Very High
Cv General 4 Under Development 1 99.60 Very High Very High Very High
Injury 9 99.52 Very High Very High Very High
Toxicity 7 98.48 Very High Very High Very High
Pain 20 97.72 Very High Very High Very High
Death 6 97.64 Very High Very High Very High
Stress 18 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AM-251 had no modulatory effect on flurbiprofen-induced cyclooxygenase (COX) inhibiting capacity as shown by PGE(2) levels.
Neg (no) Regulation (effect) of Neg (no) Positive_regulation (flurbiprofen-induced) of COX
1) Confidence 0.24 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12566162 Disease Relevance 0.08 Pain Relevance 0.57
After nerve injury, cyclooxygenase-2 (COX-2) is upregulated in spinal cord and peripheral nerve, the latter being dependent on tumor necrosis factor-alpha (TNF).
Regulation (dependent) of in spinal cord Positive_regulation (upregulated) of COX in peripheral nerve associated with necrosis, nervous system injury, cancer and spinal cord
2) Confidence 0.13 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 14697327 Disease Relevance 1.02 Pain Relevance 0.43
These results indicate that in hypothalamic structures involved in the regulation of adrenergic agonists-induced HPA stimulation COX-2 is expressed under physiological synaptic activity.
Regulation (regulation) of Positive_regulation (agonists-induced) of COX associated with agonist
3) Confidence 0.10 Published 2001 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11785775 Disease Relevance 0.22 Pain Relevance 0.34
This COX-2 immunoreactivity was greatest in animals with concomitant indomethacin-induced gastrointestinal injury, suggesting a possible role of inflammatory cytokines in COX-2 induction.
Spec (possible) Regulation (role) of Positive_regulation (induction) of COX associated with inflammation, injury and cytokine
4) Confidence 0.10 Published 1998 Journal Toxicol Pathol Section Abstract Doc Link 9502396 Disease Relevance 0.61 Pain Relevance 0.15
This study was designed to investigate the effects of peripherally released NO on cyclooxygenase (COX) expression/activation and production of PGs in carrageenan-induced inflammation.
Spec (investigate) Regulation (effects) of Positive_regulation (activation) of COX associated with inflammation
5) Confidence 0.07 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15448533 Disease Relevance 0.37 Pain Relevance 0.23
This study was designed to investigate the effects of peripherally released NO on cyclooxygenase (COX) expression/activation and production of PGs in carrageenan-induced inflammation.
Spec (investigate) Regulation (effects) of Spec (investigate) Positive_regulation (expression) of COX associated with inflammation
6) Confidence 0.07 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15448533 Disease Relevance 0.37 Pain Relevance 0.23
This study was designed to investigate the effects of peripherally released NO on cyclooxygenase (COX) expression/activation and production of PGs in carrageenan-induced inflammation.
Spec (investigate) Regulation (effects) of Spec (investigate) Positive_regulation (/) of COX associated with inflammation
7) Confidence 0.07 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15448533 Disease Relevance 0.37 Pain Relevance 0.23
However, the overall effect of NO on PGE2 production is a stimulation lasting up to 8 h incubation time, which suggests the involvement of alternative mechanisms for NO, as for example a direct stimulatory effects on COX activity or the induction of COX1.
Regulation (effects) of Positive_regulation (induction) of COX associated with cox1
8) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731738 Disease Relevance 0 Pain Relevance 0.34
Upregulation of COX-2 expression in an Alzheimer's mouse model [65] and in cell culture studies has been reported in response to A?
Regulation (reported) of Positive_regulation (Upregulation) of COX
9) Confidence 0.05 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 1.68 Pain Relevance 0.45
After nerve injury, cyclooxygenase-2 (COX-2) is upregulated in spinal cord and peripheral nerve, the latter being dependent on tumor necrosis factor-alpha (TNF).
Regulation (dependent) of Positive_regulation (upregulated) of COX in peripheral nerve associated with necrosis, nervous system injury, cancer and spinal cord
10) Confidence 0.04 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 14697327 Disease Relevance 1.02 Pain Relevance 0.43

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox