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Context Info
Confidence 0.27
First Reported 1998
Last Reported 2005
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.04
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Creb1, Jun) DNA binding (Creb1, Jun) transcription factor binding (Creb1, Jun)
cytosol (Jun) nucleoplasm (Creb1) mitochondrion (Creb1)
Creb1 (Rattus norvegicus)
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 5 87.20 High High
central sensitization 13 84.56 Quite High
midbrain 1 84.16 Quite High
Dynorphin 2 83.60 Quite High
Hippocampus 2 83.36 Quite High
Enkephalin 5 82.72 Quite High
Glutamate receptor 3 82.20 Quite High
opioid receptor 2 81.52 Quite High
Pain 5 78.12 Quite High
Inflammation 15 72.48 Quite High
Disease Link Frequency Relevance Heat
Renal Disease 3 94.84 High High
Nociception 17 86.40 High High
INFLAMMATION 16 72.48 Quite High
Disease 2 71.40 Quite High
Hypotension 1 66.92 Quite High
Pressure Volume 2 Under Development 4 65.28 Quite High
Adhesions 9 60.72 Quite High
Myocardial Infarction 2 57.28 Quite High
Targeted Disruption 5 50.00 Quite Low
Pheochromocytoma 1 48.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the factors involved in CHX-induced proENK and TH mRNA expression, the effect of CHX on activator protein-1 (AP-1), cAMP response element (CRE) binding protein (CREB), and glucocorticoid response element (GRE) was tested.
CREB Regulation (effect) of activator protein-1
1) Confidence 0.27 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10825388 Disease Relevance 0 Pain Relevance 0.21
These results indicate a cooperative effect of AP1 and CREB on PENK transcription.
CREB Regulation (effect) of AP1
2) Confidence 0.25 Published 1998 Journal DNA Cell Biol. Section Abstract Doc Link 9502431 Disease Relevance 0 Pain Relevance 0
Like other transcription factors, such as AP-1 proteins, c-fos, and c-Jun, phosphorylated CREB may participate in the downstream signal transduction cascade in the longer lasting changes in synaptic plasticity.
CREB Spec (may) Regulation (participate) of c-Jun
3) Confidence 0.21 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.43 Pain Relevance 0.72
B, but had no effect on AP-1, CREB, Sp-1, and octamer-binding proteins [14,15].
CREB Neg (no) Regulation (effect) of AP-1
4) Confidence 0.02 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.62 Pain Relevance 0.10

General Comments

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