INT74029

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 1998
Last Reported 1998
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.21
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) extracellular region (Penk) aging (Jun)
nucleus (Jun) DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
Pituitary 2
Jun (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 3 98.98 Very High Very High Very High
Neuropeptide 3 98.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pheochromocytoma 3 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, AP1 by itself is not sufficient to increase PENK transcription, as insulin-like growth factor 1 (IGF1), which stimulates AP1 activity but not cAMP production, is unable to stimulate PENK transcription.
AP1 Positive_regulation (increase) of Transcription (transcription) of PENK
1) Confidence 0.51 Published 1998 Journal DNA Cell Biol. Section Abstract Doc Link 9502431 Disease Relevance 0.06 Pain Relevance 0
Pituitary adenylate cyclase-activating polypeptide stimulates proenkephalin gene transcription through AP1- and CREB-dependent mechanisms.
AP1 Positive_regulation (stimulates) of Transcription (transcription) of proenkephalin in Pituitary associated with enkephalin
2) Confidence 0.51 Published 1998 Journal DNA Cell Biol. Section Title Doc Link 9502431 Disease Relevance 0.09 Pain Relevance 0.15
However, AP1 by itself is not sufficient to increase PENK transcription, as insulin-like growth factor 1 (IGF1), which stimulates AP1 activity but not cAMP production, is unable to stimulate PENK transcription.
AP1 Neg (unable) Positive_regulation (stimulate) of Transcription (transcription) of PENK
3) Confidence 0.47 Published 1998 Journal DNA Cell Biol. Section Abstract Doc Link 9502431 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox