INT74030

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Context Info
Confidence 0.56
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.24
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Adcyap1, Penk) cytosol (Adcyap1) signal transduction (Adcyap1)
extracellular space (Adcyap1)
Anatomy Link Frequency
Pituitary 2
Adcyap1 (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 3 99.80 Very High Very High Very High
Neuropeptide 3 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pheochromocytoma 3 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pituitary adenylate cyclase-activating polypeptide stimulates proenkephalin gene transcription through AP1- and CREB-dependent mechanisms.
adenylate cyclase-activating polypeptide Positive_regulation (stimulates) of Transcription (transcription) of proenkephalin in Pituitary associated with enkephalin
1) Confidence 0.56 Published 1998 Journal DNA Cell Biol. Section Title Doc Link 9502431 Disease Relevance 0.09 Pain Relevance 0.15
Inactivation of cAMP dependent-protein kinase (PKA) with a dominant inhibitory mutant strongly reduced PACAP-stimulated PENK transcription.
PACAP Positive_regulation (stimulated) of Transcription (transcription) of PENK
2) Confidence 0.56 Published 1998 Journal DNA Cell Biol. Section Abstract Doc Link 9502431 Disease Relevance 0.09 Pain Relevance 0
Taken together, these results indicate that PACAP stimulates PENK transcription by members of both the AP1 and the CREB families.
PACAP Positive_regulation (stimulates) of Transcription (transcription) of PENK
3) Confidence 0.56 Published 1998 Journal DNA Cell Biol. Section Abstract Doc Link 9502431 Disease Relevance 0.06 Pain Relevance 0

General Comments

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