INT74046

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Context Info
Confidence 0.80
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.05
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Calb2) cellular_component (Calb2) biological_process (Calb2)
cytoplasm (Calb2)
Anatomy Link Frequency
neurons 3
cell groups 2
nerve 1
PDL 1
lamina 1
Calb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 70 100.00 Very High Very High Very High
Neuropeptide 21 99.76 Very High Very High Very High
Enkephalin 33 99.52 Very High Very High Very High
substance P 22 99.28 Very High Very High Very High
Glutamate receptor 7 97.92 Very High Very High Very High
Raphe 10 95.16 Very High Very High Very High
GABAergic 54 90.56 High High
Pain 6 90.08 High High
ischemia 78 89.80 High High
Spinal cord 4 86.08 High High
Disease Link Frequency Relevance Heat
Cancer 79 92.44 High High
Disease 29 91.84 High High
Pain 6 90.08 High High
Cv Unclassified Under Development 72 89.80 High High
Adenofibroma 3 84.56 Quite High
Carcinoid 2 82.24 Quite High
Brenner Tumor 1 72.24 Quite High
Granulosa Cell Tumor 1 69.76 Quite High
Leydig Cell Tumor 2 68.88 Quite High
Sertoli Cell Tumor 1 67.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Topographic localization of calretinin, calbindin, VIP, substance P, CCK and metabotropic glutamate receptor immunoreactive neurons in the supramammillary and related areas of the rat.
Localization (localization) of calretinin in neurons associated with glutamate receptor, neuropeptide and substance p
1) Confidence 0.80 Published 1997 Journal Neurobiology (Bp) Section Title Doc Link 9503382 Disease Relevance 0 Pain Relevance 0.35
Enkephalin-immunoreactive cells co-localized GABA, vasoactive intestinal polypeptide and calretinin.
Localization (localized) of calretinin associated with gaba and enkephalin
2) Confidence 0.61 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9751150 Disease Relevance 0 Pain Relevance 1.06
Decrease of CR-ir neurons was detected from day 28 through day 56: a 27% decrease from day 3 to day 56 (ANOVA, p < .01), a 26% decrease from day 7 to day 28 (p = .01), and a 18% decrease from day 7 to day 56 (p < .05) was observed.
Localization (Decrease) of CR in neurons
3) Confidence 0.49 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.16 Pain Relevance 0.23
The colocalizations of p-ERK1/2 with CGRP and calretinin indicate that ERK1/2 is constitutively activated in a subpopulation of sensory and mechanoreceptive nerve terminals in the PDL.


Localization (colocalizations) of calretinin in nerve
4) Confidence 0.40 Published 2009 Journal J. Periodontol. Section Body Doc Link 19405839 Disease Relevance 0 Pain Relevance 0
In nerve fibers of the PDL, p-ERK1/2 was colocalized with PGP 9.5, CGRP, and calretinin.
Localization (colocalized) of calretinin in PDL
5) Confidence 0.40 Published 2009 Journal J. Periodontol. Section Body Doc Link 19405839 Disease Relevance 0 Pain Relevance 0
The suprachiasmatic nucleus has a complex order characterized by peptidergic cell groups (vasopressin, gastrin releasing peptide, vasoactive intestinal polypeptide, calbindin, calretinin, corticotrophin releasing factor and enkephalin) that, in most cases, substantially overlap.
Localization (releasing) of calretinin in cell groups associated with enkephalin
6) Confidence 0.37 Published 2006 Journal Neuroscience Section Abstract Doc Link 16338081 Disease Relevance 0 Pain Relevance 0.15
The suprachiasmatic nucleus has a complex order characterized by peptidergic cell groups (vasopressin, gastrin releasing peptide, vasoactive intestinal polypeptide, calbindin, calretinin, corticotrophin releasing factor and enkephalin) that, in most cases, substantially overlap.
Localization (releasing) of calretinin in cell groups associated with enkephalin
7) Confidence 0.37 Published 2006 Journal Neuroscience Section Abstract Doc Link 16338081 Disease Relevance 0 Pain Relevance 0.15
Interestingly, the alpha-Syn-immunoreactive nerve elements, in lamina X, contained little of calbindin-28KD and calretinin-31KD.
Neg (little) Localization (little) of calretinin-31KD in lamina
8) Confidence 0.13 Published 2009 Journal Neuroscience Section Abstract Doc Link 19118601 Disease Relevance 0.40 Pain Relevance 0.28
Calretinin (CALR) is another variety of neurons found in the SCN (in the core ventral part) that appears to be co-localized with VIP neurons.
Localization (localized) of Calretinin in ventral
9) Confidence 0.08 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.03
Modified microwave antigen retrieval in citrate buffer (pH 6.0) was used for analyzing antibodies to calretinin, CD34, and Ki-67.
Localization (calretinin) of calretinin
10) Confidence 0.01 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2954971 Disease Relevance 0.13 Pain Relevance 0
Antibodies to S-100 protein, calretinin, vimentin, neuron-specific enolase (NSE), and Ki-67 (MIB-1) were obtained from DakoCytomation (Kyoto, Japan).
Localization (calretinin) of calretinin in neuron
11) Confidence 0.01 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2954971 Disease Relevance 0.22 Pain Relevance 0
Immunihistochemically, the minor sex cord elements are positive for inhibin, calretinin, CD99, CD56, antikeratin antibody KL1 and MIC. [2,6]
Localization (calretinin) of calretinin
12) Confidence 0.01 Published 2008 Journal Cases J Section Body Doc Link PMC2579288 Disease Relevance 1.13 Pain Relevance 0

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